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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

C-mer proto-oncogene tyrosine kinase

MERTK, c-Mer
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Apaf-1, TIF, CAN, Gas6, HAD
Papers on MERTK
Host genetic variants influencing the clinical course of hepatitis C virus infection.
Tanaka et al., Nagoya, Japan. In J Med Virol, Feb 2016
Interestingly, these genetic variants also affect the activity of hepatitis, or disease progression in chronic hepatitis C. In addition, polymorphisms in apoptosis-related genes such as RNF7, TULP1, and MERTK are associated with fibrosis progression, and DEPDC5 and MICA variants are associated with HCV-related hepatocellular carcinoma.
Functional screen identifies kinases driving prostate cancer visceral and bone metastasis.
Witte et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, Feb 2016
Strikingly, all three RAF family members, MERTK, and NTRK2 drove the formation of bone and visceral metastasis confirmed by positron-emission tomography combined with computed tomography imaging and histology.
Recurrent mutations of chromatin remodeling genes and kinase receptors in pheochromocytomas and paragangliomas.
Dahia et al., San Antonio, United States. In Clin Cancer Res, Jan 2016
Among those, a novel germline kinase domain mutation of MERTK detected in a patient with PPGL and medullary thyroid carcinoma was found to activate signaling downstream of this receptor.
The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.
Diamond et al., Saint Louis, United States. In Nat Med, Dec 2015
The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells.
A Comprehensive Review of Mutations in the MERTK Proto-Oncogene.
Nandrot et al., Paris, France. In Adv Exp Med Biol, Dec 2015
Genetic studies on a natural animal model of recessive retinal degeneration allowed the identification of MerTK, the gene encoding the surface receptor required for POS internalization.
Tyro3 Modulates Mertk-Associated Retinal Degeneration.
LaVail et al., San Francisco, United States. In Plos Genet, Dec 2015
Mutations in MERTK cause recessive IPD phenotypes associated with the RP38 locus.
Pharmacophore-Based 3D-QSAR Modeling, Virtual Screening and Molecular Docking Analysis for the Detection of MERTK Inhibitors with Novel Scaffold.
Zhong et al., Chengdu, China. In Comb Chem High Throughput Screen, Dec 2015
MERTK plays an important role in cell biology and is correlated with many cancers, such as mantle cell lymphomas, pituitary adenomas, and T-cell acute lympholoblastic leukemia.
MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease.
Craxì et al., Palermo, Italy. In J Hepatol, Nov 2015
BACKGROUND & AIM: Homozygosity for a common non-coding rs4374383 G>A polymorphism in MERTK (myeloid-epithelial-reproductive tyrosine kinase) has been associated with the protection against fibrosis progression in chronic hepatitis C. The main study objective was to assess whether MERTK AA genotype influences liver fibrosis, and secondarily MERTK expression in patients with non-alcoholic fatty liver disease (NAFLD).
Enriched Cultures of Retinal Cells From BJNhem20 Human Embryonic Stem Cell Line of Indian Origin.
Vauhini et al., Hyderābād, India. In Invest Ophthalmol Vis Sci, Nov 2015
Mature RPE cells developed intense pigmentation within 3 months and showed ZO-1 and Phalloidin staining at cell-cell junctions and expressed RPE65, tyrosinase, bestrophin1, Mertk, and displayed phagocytic activity.
TAM receptor deficiency affects adult hippocampal neurogenesis.
Lu et al., Louisville, United States. In Metab Brain Dis, Jun 2015
The Tyro3, Axl and Mertk (TAM) subfamily of receptor protein tyrosine kinases functions in cell growth, differentiation, survival, and most recently found, in the regulation of immune responses and phagocytosis.
Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.
Sakai et al., Tokyo, Japan. In J Neuroinflammation, 2014
METHODS: In this study, c-mer proto-oncogene tyrosine kinase (Mertk) (-/-) mice, which show photoreceptor cell death due to defective retinal pigment epithelium phagocytosis, were employed as an animal model of RD.
TAM receptor signaling in immune homeostasis.
Ghosh et al., In Annu Rev Immunol, 2014
The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation.
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.
Earp et al., In Nat Rev Cancer, 2014
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial malignancies.
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Penninger et al., Vienna, Austria. In Nature, 2014
The TAM tyrosine kinase receptors Tyro3, Axl and Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl-b.
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways.
Barres et al., Stanford, United States. In Nature, 2014
This process helps to mediate synapse elimination, requires the MEGF10 and MERTK phagocytic pathways, and is strongly dependent on neuronal activity.
Homozygous mutation in MERTK causes severe autosomal recessive retinitis pigmentosa.
Hamel et al., Montpellier, France. In Eur J Ophthalmol, 2012
MERTK mutations lead to severe retinitis pigmentosa with discrete dot-like autofluorescent deposits at early stages, which are a hallmark of this MERTK-specific dystrophy.
Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.
Kang et al., Seoul, South Korea. In J Leukoc Biol, 2012
Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.
G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors.
Zhao et al., Xi'an, China. In J Neurosci, 2012
Fast neuroprotection by estradiol is partially mediated by GPR30 and the subsequent downregulation of N-methyl D-aspartate receptor NR2B-containing NMDARs.
Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction.
Prossnitz et al., Albuquerque, United States. In Hypertension, 2012
GPER is the first estrogen receptor with inhibitory activity on endothelium-dependent contractility.
Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus.
Graham et al., Aurora, United States. In Plos One, 2011
The present study explores Mer behavior following prolonged exposure to Gas6.
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