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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

X-prolyl aminopeptidase

membrane-bound APP, XPNPEP2
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APP, aminopeptidase, Angiotensin II, CAN, ACID
Papers on membrane-bound APP
The natural, peptaibolic peptide SPF-5506-A4 adopts a β-bend spiral structure, shows low hemolytic activity and targets membranes through formation of large pores.
Otzen et al., Århus, Denmark. In Biochim Biophys Acta, Aug 2015
As Aβ is a cleavage-product from the membrane-bound APP protein, we hypothesized that SPF-5506-A(4)'s activity might be linked to membrane interactions in general.
[Biological investigation of kinin-mediated angioedema].
Drouet et al., Grenoble, France. In Ann Dermatol Venereol, Mar 2015
An abnormal biological phenotype is supported by examination of susceptibility genes (SERPING1, F12 and XPNPEP2) and mutation segregation in the families.
Diagnosis and treatment of bradykinin-mediated angioedema: outcomes from an angioedema expert consensus meeting.
Boccon-Gibod et al., Penn Hills, United States. In Int Arch Allergy Immunol, 2013
The group discussed the difficulties associated with using diagnostic markers, such as the level and function of C1-INH, C1q and C4 to reliably diagnose the angioedema type, and considered the use of genetic testing to identify mutations in FXII or XPNPEP2 that have been associated with HAE-nC1-INH and ACEI-AAE, respectively.
Mycoplasma hyopneumoniae in vitro peptidase activities: identification and cleavage of kallikrein-kinin system-like substrates.
Gouvea et al., Porto Alegre, Brazil. In Vet Microbiol, 2013
The aminopeptidase P (APP) activity showed a similar profile to that of human membrane-bound APP.
Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis.
Maitland-van der Zee et al., Utrecht, Netherlands. In Pharmacogenomics, 2013
RESULTS & CONCLUSION: One gene region (XPNPEP2) was associated with ACEI-induced angioedema in three studies.
The development of a novel molecular assay examining the role of aminopeptidase P polymorphisms in acute hypotensive transfusion reactions.
Tormey et al., Buffalo, United States. In Arch Pathol Lab Med, 2013
Aminopeptidase P (APP), another important enzyme responsible for bradykinin degradation, is encoded by the polymorphic XPNPEP2 gene.
Intracellular amyloid precursor protein sorting and amyloid-β secretion are regulated by Src-mediated phosphorylation of Mint2.
Ho et al., Boston, United States. In J Neurosci, 2012
Because Aβ generation involves the internalization of membrane-bound APP via endosomes and Mints bind directly to the endocytic motif of APP, we proposed that Mints are involved in APP intracellular trafficking, which in turn, affects Aβ generation.
Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.
Steiner et al., München, Germany. In J Biol Chem, 2012
β-Secretase initially cleaves APP thereby generating a membrane-bound APP C-terminal fragment, from which γ-secretase subsequently liberates 37-43-amino acid long Aβ species.
Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.
Parent et al., Chicago, United States. In J Neurosci, 2012
Here, we characterized intrinsic signaling associated with membrane-bound APP C-terminal fragments, which are generated following APP ectodomain release by α- or β-secretase cleavage.
A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.
Hooper et al., Leeds, United Kingdom. In Hum Mutat, 2011
the genetic regulation of the XPNPEP2 gene and identify the genetic factors contributing to variance in plasma aminopeptidase P activity and ACEi-angioedema (XPNPEP2)
Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes.
Lafuente et al., Barcelona, Spain. In Pharmacogenet Genomics, 2011
This study included a complete analysis of the variability of the genes involved in bradykinin metabolism (ACE and XPNPEP2) and bradykinin receptors (BDKRB2).
Arsenic affects expression and processing of amyloid precursor protein (APP) in primary neuronal cells overexpressing the Swedish mutation of human APP.
Schliebs et al., San Luis Potosí, Mexico. In Int J Dev Neurosci, 2011
Following exposure of neuronal cells by sodium arsenite for 12h, the membrane-bound APP level was enhanced, the amount of sAPPβ released into the culture medium was slightly higher, while the levels of Aβ peptides in the culture medium were considerably lower as compared to that assayed in the absence of any drug.
Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema.
Brown et al., Nashville, United States. In Pharmacogenet Genomics, 2010
XPNPEP2 C-2399A polymorphism associates with angiotensin-converting enzyme inhibitor-associated angioedema in men but not women.
Inhibition of BACE1 for therapeutic use in Alzheimer's disease.
Yan et al., Cleveland, United States. In Int J Clin Exp Pathol, 2009
Only after this cleavage can the membrane-bound APP C-terminal fragment be subsequently cleaved by gamma-secretase to release so-called AD-causing Abeta peptides.
Genetic analysis of Factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema.
Rouleau et al., Montréal, Canada. In J Allergy Clin Immunol, 2009
females have polymorphisms associated with lower levels of APP & ACE; study suggests multiple genes may contribute to this disease
Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit.
Rao et al., Tianjin, China. In J Biol Chem, 2008
Structural comparisons suggest mechanisms for substrate selectivity in different X-prolyl peptidases.
The FE65 proteins and Alzheimer's disease.
Miller et al., London, United Kingdom. In J Neurosci Res, 2008
After sequential proteolytic processing of membrane-bound APP and release of AICD to the cytoplasm, FE65 can translocate to the nucleus to participate in gene transcription events.
Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P.
Adam et al., Grenoble, France. In J Allergy Clin Immunol, 2008
Increase in aminopeptidase P levels brought on by androgens could contribute to a more effective control of the kinin accumulation considered to be responsible for the symptoms of angioedema.
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