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Transient receptor potential cation channel, subfamily M, member 1

melastatin, TRPM1
This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: TRPM8, TRPM7, Trp7, CAN, V1a
Papers on melastatin
Shear stress activates monovalent cation channel TRPM4 in rat atrial myocytes via type 2 inositol 1,4,5-trisphosphate receptors and Ca(2+) release.
Woo et al., Taejŏn, South Korea. In J Physiol, Feb 2016
It was suppressed by intracellular Ca(2+) buffering at a fixed physiological level, inhibitors of transient receptor potential melastatin subfamily 4 (TRPM4), intracellular introduction of TRPM4 antibodies, or knock-down of TRPM4 expression, suggesting that TRPM4 carries most of this current.
Stress hormone potentiates Zn(2+)-induced neurotoxicity via TRPM7 channel in dopaminergic neuron.
Chung et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, Feb 2016
Recently, it was reported that the zinc permeable transient receptor potential melastatin 7 (TRPM7) channel may represent a novel target for neurological disorders where zinc toxicity plays an important role.
Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?
de Baaij et al., Nijmegen, Netherlands. In Diabetes, Jan 2016
In the kidney, insulin activates the renal Mg(2+) channel transient receptor potential melastatin type 6 that determines the final urinary Mg(2+) excretion.
Enhancement by citral of glutamatergic spontaneous excitatory transmission in adult rat substantia gelatinosa neurons.
Kumamoto et al., Saga, Japan. In Neuroreport, Jan 2016
Citral activates in heterologous cells transient receptor potential vanilloid-1, ankyrin-1, and melastatin-8 (TRPV1, TRPA1, and TRPM8, respectively) channels, the activation of which in the spinal lamina II [substantia gelatinosa (SG)] increases the spontaneous release of L-glutamate from nerve terminals.
3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells.
Mergler et al., Berlin, Germany. In Cell Signal, Jan 2016
3T1AM also directly activates cold-sensitive transient receptor potential melastatin 8 (TRPM8) channels in human conjunctival epithelial cells (HCjEC) at constant temperature as well as reducing rises in IL-6 release induced by transient receptor potential vanilloid 1 (TRPV1) activation by capsaicin (CAP).
Transient Receptor Potential Channels and Corneal Stromal Inflammation.
Saika et al., Wakayama, Japan. In Cornea, Nov 2015
TRP subfamily members identified in the cornea include those belonging to the canonical, vanilloid, ankyrin, or melastatin subfamilies.
Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations.
Park et al., New York City, United States. In Cell Mol Neurobiol, Oct 2015
Recent evidence implicates vascular oxidative stress and activation of the non-selective cationic channel transient receptor potential melastatin (TRPM)-2 on endothelial cells in the mechanisms of Aβ-induced neurovascular dysfunction.
Magnesium in man: implications for health and disease.
Bindels et al., Nijmegen, Netherlands. In Physiol Rev, 2015
Over the last decade, several hereditary forms of hypomagnesemia have been deciphered, including mutations in transient receptor potential melastatin type 6 (TRPM6), claudin 16, and cyclin M2 (CNNM2).
The Genetics of Deafness in Domestic Animals.
Strain, Baton Rouge, United States. In Front Vet Sci, 2014
Across species, the genes identified with deafness or white pigmentation patterns include MITF, PMEL, KIT, EDNRB, CDH23, TYR, and TRPM1 in dog, cat, horse, cow, pig, sheep, ferret, mink, camelid, and rabbit.
Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion.
Yee, State College, United States. In Cancers (basel), 2014
The goal of this article is to provide a critical review of the transient receptor potential melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular proliferation, survival, and invasion.
Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration.
Puthussery et al., Portland, United States. In Front Cell Neurosci, 2014
In contrast, photoreceptor degeneration leads to loss of synaptic expression of TRPM1 in mouse and human On bipolar cells, but strong somatic expression remains.
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Liu et al., Bethesda, United States. In Nat Cell Biol, 2014
Furthermore, we identified that TRPM7 (transient receptor potential melastatin related 7) is a MLKL downstream target for the mediation of Ca(2+) influx and TNF-induced necroptosis.
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Friese et al., Hamburg, Germany. In Nat Med, 2012
Here we show that the transient receptor potential melastatin 4 (TRPM4) cation channel is crucial in this process.
Mutation screening of TRPM1, GRM6, NYX and CACNA1F genes in patients with congenital stationary night blindness.
Zhang et al., Guangzhou, China. In Int J Mol Med, 2012
The results expand the mutation spectrum of NYX, CACNA1F and GRM6. They also suggest that NYX mutations are a common cause of congenital stationary night blindness (CSNB),No variations were found in TRPM1.
G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.
Nawy et al., Wuhan, China. In Proc Natl Acad Sci U S A, 2012
Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o) upon activation of mGluR6 closes the TRPM1 channel, perhaps via a direct interaction.
mGluR6 deletion renders the TRPM1 channel in retina inactive.
Vardi et al., Guangzhou, China. In J Neurophysiol, 2012
The results suggested that the TRPM1 channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized.
Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.
Peirson et al., Oxford, United Kingdom. In Eur J Neurosci, 2012
TRPM1 is involved in non-image-forming responses to light and may perform a functional role within photosensitive retinal ganglion cells
Ultrastructural localization and expression of TRPM1 in the human retina.
Kamermans et al., Amsterdam, Netherlands. In Invest Ophthalmol Vis Sci, 2010
In the human retina TRPM1 is expressed on ON-bipolar cell dendrites that invaginate photoreceptor terminals and is also expressed on the synaptic ribbons of a subclass of rods, suggesting a dual function for TRPM1 in the ON-pathway.
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
Clapham et al., Boston, United States. In Science, 2008
The gene transient receptor potential-melastatin-like 7 (Trpm7) encodes a protein that functions as an ion channel and a kinase.
The menthol receptor TRPM8 is the principal detector of environmental cold.
Julius et al., San Francisco, United States. In Nature, 2007
One such channel--TRP melastatin 8 (TRPM8) or cold and menthol receptor 1 (CMR1)--is activated by chemical cooling agents (such as menthol) or when ambient temperatures drop below approximately 26 degrees C, suggesting that it mediates the detection of cold thermal stimuli by primary afferent sensory neurons.
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