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Polycomb group ring finger 2

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Polycomb, Mel, Bmi-1, RING finger protein, Ding
Papers on Mel-18
MEL-18 loss mediates estrogen receptor-α downregulation and hormone independence.
Kong et al., In J Clin Invest, May 2015
The polycomb protein MEL-18 has been proposed as a tumor suppressor in breast cancer; however, its functional relevance to the hormonal regulation of breast cancer remains unknown.
USP7 cooperates with SCML2 to regulate the activity of PRC1.
Reinberg et al., New York City, United States. In Mol Cell Biol, Apr 2015
First, we show that SCML2, a Polycomb group protein that associates with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing PCGF4/BMI1), modulates the localization of USP7 and bridges USP7 with PRC1.4,
Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.
Kim et al., San Antonio, United States. In Structure, 2013
Here, we identify a protein interaction domain in BCL6 corepressor, BCOR, which binds the RING finger- and WD40-associated ubiquitin-like (RAWUL) domain of PCGF1 (NSPC1) and PCGF3 but not of PCGF2 (MEL18) or PCGF4 (BMI1).
Inhibition of PCGF2 enhances granulocytic differentiation of acute promyelocytic leukemia cell line HL-60 via induction of HOXA7.
Chung et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
PCGF2, a PRC1 gene, played a negative role in the granulocytic differentiation of human APL cells.
A methyl-deficient diet modifies early B cell development.
Kanno et al., Hiroshima, Japan. In Pathobiology, 2011
We also found changed expression levels of the Polycomb group genes (mel18, bmi1, Pc1, Pc2, Ring1A, Ring1B, Ph1) on semi-quantitative RT-PCR.
Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway.
Kong et al., Seoul, South Korea. In Oncogene, 2011
these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer.
The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines.
Avni et al., Haifa, Israel. In Eur J Immunol, 2011
Data show that Mel-18 and Ezh2 positively regulate the expression of Il17a and Il17f.
Mel-18 controls the enrichment of tumor-initiating cells in SP fraction in mouse breast cancer.
Kanno et al., Hiroshima, Japan. In Hiroshima J Med Sci, 2011
Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
Peters et al., London, United Kingdom. In Embo J, 2010
Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-purify with human PRC1-type complexes through direct interactions with the Psc orthologues MEL18 and BMI1, and with other PRC1 components.
Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancer.
Bukholm et al., Oslo, Norway. In Bmc Cancer, 2009
Bmi-1/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy.
Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells.
Kobayashi et al., Hiroshima, Japan. In Exp Hematol, 2009
observed that expression of the PcG genes-bmi1 and mel-18-is correlated with self-renewal and differentiation of HSCs. Thus, it was suggested that the balance between Bmi1 and Mel-18 regulates self-renewal of HSCs
Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands.
Bloemena et al., Amsterdam, Netherlands. In Histopathology, 2008
METHODS AND RESULTS: Expression of protein (E2F1, p16(INK4a), p53, cyclin D1, Ki67 and Polycomb group proteins BMI-1, MEL-18 and EZH2) was investigated in 49 benign and 30 primary malignant myoepithelial tumours and five histologically benign recurrences by immunohistochemistry and the findings correlated with histopathological characteristics.
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.
Peters et al., London, United Kingdom. In Plos One, 2008
Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) proteins, MEL18 and BMI1.
Mel-18 interacts with RanGAP1 and inhibits its sumoylation.
Sarge et al., Lexington, United States. In Biochem Biophys Res Commun, 2008
The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1.
Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.
Ostergaard et al., Århus, Denmark. In Eur J Haematol, 2008
To analyse the role of deregulated PcG genes in acute myeloid leukaemia (AML), we determined by RQ-PCR the expression of the PcG genes BMI-1, MEL18, SCML2, YY1 and EZH2, and the downstream PcG targets HOXA4, HOXA9 and MEIS1 in diagnostic bone marrow samples from 126 AML patients.
High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma.
Bloemena et al., Amsterdam, Netherlands. In J Clin Pathol, 2008
METHODS: Expression of the cell cycle proteins p53, cyclin D1, p16(INK4a), E2F1 and Ki-67, together with the Polycomb group (PcG) proteins BMI-1, MEL-18, EZH2 and EED was investigated immunohistochemically 21 formalin-fixed, paraffin-embedded primary ACCs in relation to tumour characteristics.
MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation.
Sarge et al., Lexington, United States. In J Biol Chem, 2008
Here we show that HSF2 interacts with the polycomb protein MEL-18, that this interaction decreases during mitosis, and that overexpression and RNA interference-mediated reduction of MEL-18 result in decreased and increased HSF2 sumoylation, respectively.
Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene.
Nakayama et al., Chiba, Japan. In Immunity, 2001
The mouse counterpart of this gene regulates the expression of Th2 cytokines, and plays a critical role in Th2 cell differentiation and Th-2 dependent immune responses.
mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25.
Kanno et al., Chiba, Japan. In Immunity, 1998
mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity.
The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors.
Koseki et al., Chiba, Japan. In Immunity, 1997
mel-18 is a mammalian homolog of Drosophila melanogaster Polycomb group genes.
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