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Mitogen-activated protein kinase kinase kinase 2

MEKK2, MEK kinase 2
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAPK, JNK, AP-1, MEKK3, ERK5
Papers on MEKK2
Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity.
Scott et al., Durham, United States. In Biochem Biophys Res Commun, Sep 2015
The kinase MEKK2 (MAP3K2) may play an important role in tumor growth and metastasis for several cancer types.
The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.
Ye et al., Tianjin, China. In Cancer Lett, 2015
Moreover, we showed that HBXIP activated ERK1/2 through up-regulating MEKK2.
Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
An et al., Shanghai, China. In Nat Commun, 2014
Stk38 constitutively associates with ubiquitin E3 ligase Smurf1, and facilitates Smurf1-mediated MEKK2 ubiquitination and degradation.
MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells.
Cuevas et al., Maywood, United States. In Biochem J, 2014
The intracellular kinase MEKK2 (mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase 2) is an upstream regulator of JNK (c-Jun N-terminal kinase), but additional functions for MEKK2 have not been well defined.
Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
Rajalingam et al., Frankfurt am Main, Germany. In Embo J, 2014
Extracellular-signal-regulated kinase 5 (ERK5) is a unique, conserved member of the MAPK family and is activated in response to various stimuli through a three-tier cascade constituting MEK5 and MEKK2/3.
Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.
Zhang et al., Nanjing, China. In Cancer Immunol Res, 2014
Specifically, genetically engineered expression of higher levels of miR17/20a in the miR17-92 cluster in both murine breast cancer and colon cancer cells triggered natural killer (NK)-cell recognition by inhibiting the expression of MHC class I (H-2D) through the Mekk2-Mek5-Erk5 pathway.
MEKK2 regulates focal adhesion stability and motility in invasive breast cancer cells.
Cuevas et al., Maywood, United States. In Biochim Biophys Acta, 2014
MEK Kinase 2 (MEKK2) is a serine/threonine kinase that functions as a MAPK kinase kinase (MAP3K) to regulate activation of Mitogen-activated Protein Kinases (MAPKs).
Overexpression of MEKK2 is associated with colorectal carcinogenesis.
Wang et al., Shenzhen, China. In Oncol Lett, 2013
Mitogen-activated protein kinase kinase kinase 2 (MEKK2) is an important upstream mediator of the extracellular signal-regulated kinase 5 signaling cascade that is essential for a number of cellular functions, including mitogenesis, differentiation and oncogenic transformation.
Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.
Johnson et al., Chapel Hill, United States. In Oncogene, 2012
Data suggest that MEKK2 and MLK3 represent untargeted kinases in tumor biology for potential therapeutic development.
A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.
Yao et al., Durham, United States. In Mol Cell, 2012
Data show that HDAC4 binds and promotes the deacetylation and activation of a key MAP3 kinase, MEKK2.
Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2.
Zhang et al., Tianjin, China. In Acta Pharmacol Sin, 2011
Hepatitis B virus X protein enhances the growth of hepatoma cells through upregulation of MEKK2.
The kinases MEKK2 and MEKK3 regulate transforming growth factor-╬▓-mediated helper T cell differentiation.
Su et al., New Haven, United States. In Immunity, 2011
MEKK2 alone can suppress T-cell TGF-beta responses. MEKK2 or MEKK3 can cause ERK1/2 to phosphorylate SMAD2/3 and suppress R-SMAD-dependent transcription. MEKK2 and MEKK3 play overlapping roles in regulating Th-cell differentiation via TGF-beta
Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction.
Seger et al., Israel. In Plos One, 2009
Calcium regulation of EGF-induced ERK5 activation is mediated through interaction of MEKK2 with the adaptor protein Lad1.
Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants.
Ito et al., Fukuoka, Japan. In Sci Stke, 2007
The canonical PB1 dimerization is required for the formation of complexes between p40(phox) and p67(phox) (for activation of the NADPH oxidase crucial for mammalian host defense), between the scaffold Bem1 and the guanine nucleotide exchange factor Cdc24 (for polarity establishment in yeasts), and between the polarity protein Par6 and atypical protein kinase C (for cell polarization in animal cells), as well as for the interaction between the mitogen-activated protein kinase kinase kinases MEKK2 or MEKK3 and the downstream target mitogen-activated protein kinase kinase MEK5 (for early cardiovascular development in mammals).
Cell signaling and function organized by PB1 domain interactions.
Campuzano et al., Madrid, Spain. In Mol Cell, 2006
The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity.
A CD36-dependent signaling cascade is necessary for macrophage foam cell formation.
Silverstein et al., Cleveland, United States. In Cell Metab, 2006
We demonstrated by coimmunoprecipitation and pull-down assays that the macrophage scavenger receptor CD36 associates with a signaling complex containing Lyn and MEKK2.
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation.
Zhang et al., Bethesda, United States. In Cell, 2005
However, loss of Smurf1 does not affect the canonical Smad-mediated intracellular TGFbeta or BMP signaling; instead, it leads to accumulation of phosphorylated MEKK2 and activation of the downstream JNK signaling cascade.
Live cell fluorescence imaging of T cell MEKK2: redistribution and activation in response to antigen stimulation of the T cell receptor.
Monks et al., Denver, United States. In Immunity, 1999
In this study, immunocytochemistry and live cell fluorescence imaging demonstrate that T cell MEK kinase 2 (MEKK2) is translocated to the T cell/antigen-presenting cell interface in response to antigen activation.
The TAO of MEKK.
Johnson et al., Denver, United States. In Front Biosci, 1998
The biological roles of MEKK2, 3 and 4 are under investigation and undoubtedly homologous deletion of these MEKK family members will be invaluable at determining the biological functions of these MEKKs.
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