The Accomplices of NF-κB Lead to Radioresistance.
Beijing, China. In Curr Protein Pept Sci, 2014
The primary purpose of this review is to introduce the studies of the signaling mechanisms of IR in NF-κB activation, such as ROS/NF-κB, ATM or DNA-PK/MAPKK/ p90rsk, PI3K/AKT/IKK and k-ras/c-raf/ MEKK/ NF-κB pathways.
MEK1/2 inhibitors in the treatment of gynecologic malignancies.
Houston, United States. In Gynecol Oncol, 2014
While several three-tiered MAPK cascades have been elucidated in mammals, the prototypical pathway involves a network of proteins and kinases including the Rat sarcoma protein (Ras), mitogen-activated protein kinase kinase kinase (Raf or MAP3K), mitogen-activated protein kinase kinase (MEK or MAP2K), and extracellular signal regulated protein kinase (ERK or MAPK).
Glutamate signalling in roots.
Lancaster, United Kingdom. In J Exp Bot, 2014
The recent finding that the MEKK1 gene is a positive regulator of glutamate sensitivity at the root tip has provided genetic evidence for the existence in plants of a glutamate signalling pathway analogous to those found in animals.