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Mitogen-activated protein kinase kinase 5

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: ERK5, MAPK, ERK1, CAN, ERK
Papers using MEK5 antibodies
Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells
Woo Chang-Hoon et al., In Anatomy & Cell Biology, 2007
... BIX 02189, a specific inhibitor of MEK5, was purchased from Selleck Chemicals (Houston, TX, USA) ...
Regulation of the G2–M cell cycle progression by the ERK5–NFκB signaling pathway
Xia Zhengui et al., In The Journal of Cell Biology, 1994
... (Upstate Biotechnology), anti–phospho-IκB Ser32 or Ser36 (Calbiochem), anti–phospho- IKK Ser180/181 and anti-IκB (Cell Signaling Technologies), anti-MEK5 antibody (Santa Cruz Biotechnology, Inc.), and anti-ERK1/2 antibody ...
Papers on MEK5
BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.
Miyazono et al., Uppsala, Sweden. In Stem Cell Reports, Feb 2016
In contrast, the MEK5-ERK5 pathway mediates BMP-4-induced self-renewal of mESCs by inducing Klf2, a critical factor for the ground state pluripotency.
Susceptible genes of restless legs syndrome in migraine.
Wang et al., Taipei, Taiwan. In Cephalalgia, Jan 2016
METHODS: Thirteen single-nucleotide polymorphisms (SNPs) at six RLS risk loci (MEIS1, BTBD9, MAP2K5, PTPRD, TOX3, and an intergenic region on chromosome 2p14) were genotyped in 211 migraine patients with RLS and 781 migraine patients without RLS.
The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3.
Mayadas et al., Boston, United States. In Proc Natl Acad Sci U S A, Dec 2015
Both CCM2L and CCM2 interfere with MEKK3 activation and its ability to phosphorylate MEK5, a downstream target.
Association of low ferritin with PLM in the Wisconsin Sleep Cohort.
Mignot et al., Palo Alto, United States. In Sleep Med, Nov 2015
Analyses were performed using a linear model with PLM category above and below 15 PLM/h (periodic leg movement index, PLMI) as the dependent variable, and adjusting for known covariates, including previously associated single-nucleotide polymorphisms (SNPs) within BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD.
Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR).
Gilbert-Diamond et al., United States. In Biodata Min, 2014
We identified interactions between genes involved in mitochondrial dysfunction (POLG2), cholesterol metabolism (SOAT2), lipid metabolism (CYP11B2), cell adhesion (EZR), cell proliferation (MAP2K5), and insulin resistance (IGF1R).
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
Dejana et al., Milano, Italy. In Embo Mol Med, 2014
Here, we report that Ccm1 ablation leads to the activation of a MEKK3-MEK5-ERK5-MEF2 signaling axis that induces a strong increase in Kruppel-like factor 4 (KLF4) in ECs in vivo.
Copper is required for oncogenic BRAF signalling and tumorigenesis.
Counter et al., Durham, United States. In Nature, 2014
Conversely, a MEK1-MEK5 chimaera that phosphorylated ERK1/2 independently of Cu or an active ERK2 restored the tumour growth of murine cells lacking Ctr1.
Gαq signalling: the new and the old.
Ribas et al., Madrid, Spain. In Cell Signal, 2014
Recently, the activation of ERK5 MAPK by Gq-coupled receptors has also been described as a novel PLCβ-independent signalling axis that relies upon the interaction between this G protein and two novel effectors (PKCζ and MEK5).
What model organisms and interactomics can reveal about the genetics of human obesity.
Schiöth et al., Uppsala, Sweden. In Cell Mol Life Sci, 2012
Here, we searched biological databases and discovered 33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, TUB, ZNF608, FAIM2, KCTD15, LINGO2, POC5, PTBP2, TMEM18, TMEM160).
Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population.
Wang et al., Guangzhou, China. In Dna Cell Biol, 2012
data indicate that the rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer
Meta-analysis identifies common variants associated with body mass index in east Asians.
Shu et al., Nashville, United States. In Nat Genet, 2012
We identified ten BMI-associated loci at genome-wide significance (P < 5.0 × 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes.
ERK5 and its role in tumour development.
Cook et al., Cambridge, United Kingdom. In Biochem Soc Trans, 2012
The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module.
MEK5/ERK5 pathway: the first fifteen years.
Beckman et al., New Orleans, United States. In Biochim Biophys Acta, 2012
While conventional MAP kinase pathways are one of the most highly studied signal transduction molecules, less is known about the MEK5 signaling pathway.
MEK5/ERK5/mef2: a novel signaling pathway affected by hepatitis C virus non-enveloped capsid-like particles.
Georgopoulou et al., Greece. In Biochim Biophys Acta, 2011
HCVne particles are capable of inducing the recently discovered ERK5 pathway, in a dose dependent way.
Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population.
Wang et al., Cleveland, United States. In Sleep Med, 2011
Variants in MEIS1, BTBD9, and MAP2K5/SKOR1 confer a significant risk of restless legs syndrome in a United States population.
Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
Rönnstrand et al., Malmö, Sweden. In Biochem Biophys Res Commun, 2011
These results suggest that MEK5/ERK5 is important for FLT3-ITD induced hematopoietic transformation.
MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells.
Pober et al., New Haven, United States. In Microcirculation, 2011
MEK5 activation by laminar shear stress inhibits inflammatory responses in microvascular endothelial cells, in part through ERK5-dependent induction of KLF4
Genome-wide association studies of sleep disorders.
Wu et al., Philadelphia, United States. In Chest, 2011
These studies have identified four gene variants associated with restless legs syndrome (BTBD9, MEIS1, MAP2K5/LBXCOR1, and PTPRD) and two variants associated with narcolepsy (one in the T-cell receptor α locus and another between CPT1B and CHKB).
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
Meitinger et al., München, Germany. In Nat Genet, 2007
In a genome-wide association study we found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protein kinase MAP2K5 and the transcription factor LBXCOR1 on chromosomes 2p, 6p and 15q, respectively.
MAP kinase signalling cascade in Arabidopsis innate immunity.
Sheen et al., Boston, United States. In Nature, 2002
Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase.
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