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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Low density lipoprotein receptor-related protein 2

megalin, gp330
receptor for low density lipoprotein and a major kidney glomerular antigen for rat Heymann nephritis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, Serum albumin, V1a, CD45, ACID
Papers using megalin antibodies
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... cryosections were treated with 0.1 per cent Triton-X 100 for 30 min and stained with anti-megalin, mouse anti-GFP (Stressgen, USA), anti-F4/80 (Abcam, UK) and anti-vWF (Santa ...
Papers on megalin
Sub-chronic exposure to fluoride impacts the response to a subsequent nephrotoxic treatment with gentamicin.
Del Razo et al., Mexico. In J Appl Toxicol, Feb 2016
Moreover, fluoride decreased the expression of megalin, a molecule necessary for internalization of gentamicin into the proximal tubule, potentially reducing gentamicin accumulation.
Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease.
Birn et al., Århus, Denmark. In Kidney Int, Jan 2016
Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin.
Evaluation of cystatin C as an early biomarker of cadmium nephrotoxicity in the rat.
Edwards et al., Downers Grove, United States. In Biometals, Jan 2016
The Cd-induced changes in cystatin C labelling paralleled those of the brush border transport protein, megalin, which has been implicated as a mediator of cystatin C uptake in the proximal tubule.
Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes.
Köttgen et al., Greifswald, Germany. In Diabetes, Jan 2016
Experiments using streptozotocin-treated diabetic Rab38 knockout and control rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout vs. control rats.
The role of the Lowe syndrome protein OCRL in the endocytic pathway.
Erdmann et al., In Biol Chem, Jan 2016
In particular in vitro and in vivo evidence demonstrates an important role of OCRL in recycling of megalin, a multi-ligand receptor crucial for reabsorption of nutrients in the proximal tubulus, a process severely impaired in Lowe syndrome patients.
Retinoid Homeostatic Gene Expression in Liver, Lung and Kidney: Ontogeny and Response to Vitamin A-Retinoic Acid (VARA) Supplementation from Birth to Adult Age.
Ross et al., United States. In Plos One, Dec 2015
Gene transcripts for Lrat and Rbp4 in liver and Raldh-1 and Raldh-3 in lung, did not differ in the neonatal period but were higher, P<0.05, in adults, while Cyp26B1, Stra6, megalin, and Raldh-2 in lung did not differ from perinatal to adult ages.
Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease.
Saito et al., Japan. In J Am Soc Nephrol, Dec 2015
To elucidate the mechanism underlying this relationship, we investigated the role of the endocytic receptor megalin in proximal tubule epithelial cells (PTECs).
The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery.
Andersen et al., Oslo, Norway. In J Control Release, Sep 2015
Here, we review our current understanding of albumin homeostasis with a particular focus on the impact of the cellular receptors, namely the neonatal Fc receptor (FcRn) and the cubilin-megalin complex, and we discuss their importance on uses of albumin in drug delivery.
Variable expression pattern in Donnai-Barrow syndrome: Report of two novel LRP2 mutations and review of the literature.
Al-Zaidan et al., Riyadh, Saudi Arabia. In Eur J Med Genet, May 2015
The disorder results from mutations in the low density lipoprotein receptor-related protein 2 gene LRP2 that maps to chromosome 2q31.1.
Regulation of Selenium Metabolism and Transport.
Hill et al., Nashville, United States. In Annu Rev Nutr, 2014
N-terminal Sepp1 forms are taken up in the renal proximal tubule by another receptor, megalin.
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes.
Kestenbaum et al., Seattle, United States. In Jama, 2012
Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D. OBJECTIVE: To investigate whether common variation within genes encoding the vitamin D-binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical outcomes.
Significant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese population.
Wakai et al., Nagoya, Japan. In Gene, 2012
This study confirmed that LRP2 rs2544390 C/T at intron 1 was associated with serum uric acid levels among Japanese males with SLC22A12 258WW, SLC2A9 rs11722228C allele, ABCG2 126QQ and 141Q allele.
Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney.
Höcherl et al., Regensburg, Germany. In Kidney Int, 2012
Expression of megalin and cubilin is decreased during experimental endotoxemia, which may contribute to an increase in urine levels of albumin during acute renal failure.
Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets.
Buxbaum et al., New York City, United States. In Am J Hum Genet, 2012
analysis of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders
Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults.
Zonderman et al., Baltimore, United States. In Am J Clin Nutr, 2012
Sex-specific VDR and Megalin gene variations can modify age-related cognitive decline among US adults.
Association between low density lipoprotein receptor-related protein 2 gene polymorphisms and bone mineral density variation in Chinese population.
Zhang et al., Shanghai, China. In Plos One, 2010
A total of 330 Chinese female-offspring nuclear families with 1088 individuals and 400 Chinese male-offspring nuclear families with 1215 individuals were genotyped at six tag single nucleotide polymorphisms of the LRP2 gene.
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
CPNDS Consortium et al., Vancouver, Canada. In Nat Genet, 2009
Candidate gene studies have previously reported associations of cisplatin ototoxicity with genetic variants in the genes encoding glutathione S-transferases and megalin.
PET imaging of leptin biodistribution and metabolism in rodents and primates.
Friedman et al., New York City, United States. In Cell Metab, 2009
PET imaging using (18)F- and (68)Ga-labeled leptin revealed that, in mouse, the hormone was rapidly taken up by megalin (gp330/LRP2), a multiligand endocytic receptor localized in renal tubules.
Properties of the glomerular barrier and mechanisms of proteinuria.
Deen et al., Göteborg, Sweden. In Physiol Rev, 2008
The small amounts of albumin filtered will be reabsorbed by the megalin-cubulin complex and degraded by the proximal tubular cells.
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes.
Pober et al., Boston, United States. In Nat Genet, 2007
Study mapped Donnai-Barrow syndrome to chromosome 2q23.3-31.1 and identified LRP2 mutations in six families with Donnai-Barrow syndrome and one family with facio-oculo-acoustico-renal syndrome.
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