GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
TBC1 domain family, member 9
MDR1, TBC1D9
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Top mentioned proteins:
CD45, Gp, CAN, HAD, POLYMERASE
Papers using
MDR1
antibodies
Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model.
Supplier
In PLoS ONE, 2007
... GST-π(3369), PARP(9532), Cleaved PARP(9541), and BAX were from Cell Signaling (Danvers, MA); TrkB(sc-8316), GSK-3b(sc-9166), and MDR1(sc-55510) were from Santa Cruz Biotechnology, Inc ...
Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells
Supplier
In International Journal of Biological Sciences, 2005
... The phospho-glycoprotein (P-gp) MDR1 mouse monoclonal antibody and FITC-conjugated goat anti-mouse IgG were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Papers on
MDR1
Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.
New
Nanning, China. In Acta Pharmacol Sin, Feb 2016
METHODS: Human umbilical vein endothelial cells (HUVECs) were treated with ginkgolide B. The expression of PXR, CYP3A4, MDR1, VCAM-1, E-selectin and caspase-3 were quantified with qRT-PCR and Western blot analysis.
Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.
New
Monroe, United States. In Biochim Biophys Acta, Feb 2016
APPSWE mice were bred with mdr1a/b knockout mice to produce littermates that were divided into three groups; APP(+)/mdr1(+/+), APP(+)/mdr1(+/-) and APP(+)/mdr1(-/-).
RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.
New
Ōsaka, Japan. In Tumour Biol, Feb 2016
RANKL stimulation of RANK-expressing cells increased multidrug resistance protein 1 (MDR1), breast cancer resistance protein (BCRP), and lung resistance protein 1 (LRP1) expression and decreased Bim expression through various signaling molecules.
MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.
New
Tokushima, Japan. In Oncotarget, Feb 2016
Likewise, when expression of membrane transporter proteins was determined, there were no significant differences in expression levels of BSEP, MDR1, MRP2, BCRP, MRP4 and OCT1 between resistant clones and parent cells.
Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.
New
Impact
Heidelberg, Germany. In Nat Methods, Dec 2015
We also observed cellular thermal shifts in pervanadate-induced T cell-receptor signaling, delineating the membrane target CD45 and components of the downstream pathway, and with drugs affecting the transmembrane transporters ATP1A1 and MDR1.
CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis.
Review
New
Shenyang, China. In World J Gastroenterol, Oct 2015
AIM: To evaluate the correlations between cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and multi-drug resistance 1 (MDR1) genes polymorphisms with ulcerative colitis (UC) risk.
Influence of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on expression of P-glycoprotein and cytochrome P450 3A in sheep.
Review
New
Hannover, Germany. In J Steroid Biochem Mol Biol, Sep 2015
UNASSIGNED: In order to improve calcium and phosphorus balance, beef cattle and dairy cows can be supplemented with vitamin D. However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems.
Whole-genome characterization of chemoresistant ovarian cancer.
New
Impact
Brisbane, Australia. In Nature, Jun 2015
We observed several molecular events associated with acquired resistance, including multiple independent reversions of germline BRCA1 or BRCA2 mutations in individual patients, loss of BRCA1 promoter methylation, an alteration in molecular subtype, and recurrent promoter fusion associated with overexpression of the drug efflux pump MDR1.
Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy.
Review
Johannesburg, South Africa. In Biomed Res Int, 2014
The overexpression of the MDR1 P-glycoprotein has been related to the occurrence of multidrug resistance in CNS diseases.
Genetic susceptibility in childhood acute leukaemias: a systematic review.
Review
Rio de Janeiro, Brazil. In Ecancermedicalscience, 2014
We observed that the most frequently investigated genes were: NQO1, GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, CYP2D6, CYP2E1, MDR1 (ABCB1), XRCC1, ARID5B, and IKZF1.
New insights into the mechanisms of multidrug resistance in cancers.
Review
Tabrīz, Iran. In Cell Mol Biol (noisy-le-grand), 2014
MDR1 overexpression is one form of the multidrug resistance (MDR) phenotype, which can be acquired by patients initially responsive to chemotherapy.
Relationships of related genetic polymorphisms and individualized medication of tacrolimus in patients with renal transplantation.
Nanjing, China. In Int J Clin Exp Med, 2014
The genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 in 216 RT patients were detected by PCR-RFLP, the genetic and clinical factors and blood concentration/dose × body weight (C/D) values of tacrolimus were performed the single factor correlation analysis, and established the dose prediction algorithm of tacrolimus by stepwise multiple regression analysis.
MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric cancer patients treated with postoperative adjuvant chemotherapy.
GeneRIF
Nanjing, China. In Asian Pac J Cancer Prev, 2010
The MDR1 gene CT/TT genotype of C3435T was significantly associated with a shorter progression-free survival (PFS) and overall survival (OS).
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Impact
Boston, United States. In Lancet, 2010
BACKGROUND: Clopidogrel and prasugrel are subject to efflux via P-glycoprotein (encoded by ABCB1, also known as MDR1).
CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of Bcl-2 and MDR1 genes than CD34- cells in childhood AML.
GeneRIF
Minsk, Belarus. In Ann Hematol, 2008
CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of MDR19TBC1 domain family member 9 (with GRAM domain) ) genes than CD34- cells in childhood AML
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Impact
Bethesda, United States. In Science, 2007
We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions.
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.
Review
Impact
Budapest, Hungary. In Physiol Rev, 2006
We treat in detail the biochemistry, cell biology, and physiology of the ABCB1 (MDR1/P-glycoprotein) and the ABCG2 (MXR/BCRP) proteins and describe emerging information related to additional ABCB- and ABCG-type transporters with a potential role in drug and xenobiotic resistance.
Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1.
GeneRIF
Madrid, Spain. In Clin Infect Dis, 2006
Plasma levels of atazanavir were significantly higher in patients with MDR1 genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations.
