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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Solute carrier family 16, member 7

MCT2, monocarboxylate transporter 2
transports lactate, pyruvate, and ketone bodies; may be involved in neuronal metabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MCT1, ACID, V1a, CAN, HAD
Papers on MCT2
Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells.
Pedersen et al., Copenhagen, Denmark. In Pancreas, Feb 2016
Lactate influx capacity was highest in AsPC-1 cells and lowest in HPDE cells and was inhibited by the MCT inhibitor α-cyano-4-hydroxycinnamate (4-CIN), MCT1/MCT2 inhibitor AR-C155858, or knockdown of MCT1 or MCT4.
Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprogramming taking place following cerebral ischemia.
Pellerin et al., Lausanne, Switzerland. In Neuroscience, Feb 2016
After 1 hour of reperfusion, an upregulation of the three MCTs was observed in the striatum (MCT1 ipsilateral 2.73 ± 0.2 and contralateral 2.01 ± 0.4; MCT2 ipsilateral 2.1 ± 0.1; MCT4 ipsilateral 1.65 ± 0.1) and in the surrounding cortex of both the ipsilateral (MCT1 2.4 ± 0.4; MCT2 1.62 ± 0.2; MCT4 1.31 ± 0.1) and contralateral (MCT1 2.78 ± 0.4; MCT2 1.76 ± 0.2) hemispheres, compared to the corresponding sham hemispheres.
Expression of Monocarboxylate Transporter Isoforms in Rat Skeletal Muscle Under Hypoxic Preconditioning and Endurance Training.
Bansal et al., Delhi, India. In High Alt Med Biol, Jan 2016
MCT2 protein expression increased after training only and MCT4 protein expression decreased both in preconditioning and hypoxic training.
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors.
Zerbini et al., Braga, Portugal. In Oncotarget, Dec 2015
The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients' clinicopathological parameters.
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.
Abe et al., Tokushima, Japan. In Oncotarget, Nov 2015
All MM cells tested constitutively expressed MCT1 and MCT4, and most expressed MCT2.
Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters.
Qing et al., Wuhan, China. In Oncogene, Nov 2015
Mechanistically, we identified that the proton-coupled monocarboxylate transporter 1 (MCT1) and MCT2, which enable efficient 3-BrPA uptake by cancer cells, were selectively activated by Myc.
Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer.
Massie et al., Porto, Portugal. In Oncotarget, Sep 2015
Monocarboxylate Transporter 2 (MCT2) is a major pyruvate transporter encoded by the SLC16A7 gene.
Interaction between basigin and monocarboxylate transporter 2 in the mouse testes and spermatozoa.
Toshimori et al., Chiba, Japan. In Asian J Androl, Aug 2015
Since basigin is known to be a chaperone for the monocarboxylate transporter 1 (MCT1), the localization of basigin, MCT1 and MCT2 was examined during postnatal testicular development.
Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction.
Bergersen, Oslo, Norway. In J Cereb Blood Flow Metab, Feb 2015
The localization and function of HCAR1 and the three MCTs (MCT1, MCT2, and MCT4) expressed in brain constitute the focus of this review.
Monocarboxylate transporters in temporal lobe epilepsy: roles of lactate and ketogenic diet.
Bergersen et al., Oslo, Norway. In Brain Struct Funct, 2015
Emphasis will be placed on the role of energy substrates (lactate and ketone bodies) and their transporter molecules, particularly monocarboxylate transporters 1 and 2 (MCT1 and MCT2).
Immunohistochemical localization of GLUT3, MCT1, and MCT2 in the testes of mice and rats: the use of different energy sources in spermatogenesis.
Iwanaga et al., Japan. In Biomed Res, 2014
Monocarboxylate transporter (MCT), responsible for the transport of lactate and other monocarboxylates via the cell membrane, is abundant in the testes and sperm (MCT1, MCT2, and MCT4).
The SLC16 gene family - structure, role and regulation in health and disease.
Halestrap, Bristol, United Kingdom. In Mol Aspects Med, 2013
Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane.
Metabolism, compartmentation, transport and production of acetate in the cortical brain tissue slice.
Bröer et al., Australia. In Neurochem Res, 2012
Acetate is a good substrate for the neuronal monocarboxylate transporter MCT2 (K(M) = 2.58 ± 0.8) and the glial MCT1 but a poor substrate for the glial MCT4.
Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus.
Bergersen et al., Oslo, Norway. In Glia, 2012
Light microscopic immunohistochemistry revealed significantly less perivascular MCT2 immunoreactivity in the hippocampal formation in medial temporal lobe epilepsy than in non-MTLE patients
Basigin interacts with both MCT1 and MCT2 in murine spermatozoa.
Wennemuth et al., Homburg, Germany. In J Cell Physiol, 2012
Data suggest that basigin interacts with MCT1 and MCT2 to locate them properly in the membrane of spermatogenic cells and that this may enable sperm to utilize lactate as an energy substrate contributing to cell survival.
The monocarboxylate transporter family--Structure and functional characterization.
Halestrap, Bristol, United Kingdom. In Iubmb Life, 2012
MCT1, MCT3, and MCT4 bind preferentially to basigin and MCT2 to embigin.
Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier.
Ganapathy et al., Toyama, Japan. In Microvasc Res, 2011
Transfer of nicotinate from blood to retina across the inner blood-retinal barrier occurs primarily via H(+)-coupled monocarboxylate transporters.
Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apnea.
Gozal et al., Chicago, United States. In J Neurosci, 2011
prolonged exposures to intermittent hypoxia mimicking sleep apnea are associated with increased CNS vulnerability to ischemia that is mediated, at least in part, by concomitant decreases in the expression and function of MCT2.
Astrocyte-neuron lactate transport is required for long-term memory formation.
Alberini et al., New York City, United States. In Cell, 2011
Disrupting the expression of the neuronal lactate transporter MCT2 also leads to amnesia that is unaffected by either L-lactate or glucose, suggesting that lactate import into neurons is necessary for long-term memory.
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.
Baltazar et al., Braga, Portugal. In Bmc Cancer, 2010
Data show that a significant increase of MCT2 and MCT4 expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 and CD147 expression in prostate tumour cells was observed when compared to normal tissue.
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