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Minichromosome maintenance complex component 6

MCM6, mis5
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MCM2, CAN, MCM4, PCNA, Lac
Papers on MCM6
The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Hoang et al., Toulouse, France. In Proc Natl Acad Sci U S A, Feb 2016
Here, we show that LMO2 is recruited to DNA replication origins by interaction with three essential replication enzymes: DNA polymerase delta (POLD1), DNA primase (PRIM1), and minichromosome 6 (MCM6).
Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.
Ahnfelt-Rønne et al., Denmark. In Mol Endocrinol, Jan 2016
These included several proteins, not previously associated with pregnancy-induced islet expansion, such as CLIC1, STMN1, MCM6, PPIB, NEDD4, and HLTF.
Extensive Admixture and Selective Pressure Across the Sahel Belt.
Pereira et al., Porto, Portugal. In Genome Biol Evol, Dec 2015
The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-African ancestry.
ATR inhibition rewires cellular signaling networks induced by replication stress.
Beli et al., Frankfurt am Main, Germany. In Proteomics, Dec 2015
Furthermore, our data reveal the ATR-dependent phosphorylation following replication stress and discover novel putative ATR target sites on MCM6, TOPBP1, RAD51AP1 and PSMD4.
Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer.
Imkamp et al., Hannover, Germany. In Anticancer Res, Oct 2015
RESULTS: The following genes appeared to be possibly related to the metastatic potential of the tumor: ELOVL fatty acid elongase 7 (ELOVL7), enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), gastrulation brain homeobox 2 (GBX2), golgi membrane protein 1 (GOLM1), homeobox C6 (HOXC6), minichromosome maintenance complex component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (XPO6).
[Lactose intolerance: past and present. Part 1].
Buzás, Budapest, Hungary. In Orv Hetil, Oct 2015
Adult-type hypolactasia is caused by a polymorphism of the MCM6 gene located upstream from the lactase gene on the long arm of the chromosome 2.
Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma.
Gauchotte et al., Nancy, France. In Lung Cancer, Aug 2015
The first objective of this study was to analyze the expression of HuR in a series of NSCLC and to correlate this to two proliferation markers, Ki-67 and MCM6.
G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.
Irie et al., Mito, Japan. In J Biochem, Jun 2015
Consistent with this notion, the binding to MCM6 is comparable between the mutant MCM4 and wild-type MCM4.
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Wang et al., Beijing, China. In Cancer Cytopathol, 2014
RESULTS: Tumor protein 53 (TP53), TP63, Ki67, epidermal growth factor receptor (EGFR), minichromosome maintenance complex component 6 (MCM6), MCM7, uncharacterized proteins KIAA1522 and KIAA0317, and ubiquitin-protein ligase UHR1 (ICBP90) frequently presented high expression in bronchial brushing specimens from patients who had lung cancer compared with patients who had benign lung lesions.
The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells.
Van Seuningen et al., Lille, France. In Biochim Biophys Acta, 2014
MCM6 and TSG101 tumor-associated markers were also decreased.
Detecting recent positive selection with high accuracy and reliability by conditional coalescent tree.
He et al., Shanghai, China. In Mol Biol Evol, 2014
On empirical data, validated functional causal variants of four well-known positive selected genes were all successfully localized by our method, such as ADH1B, MCM6, APOL1, and HBB.
Plant MCM proteins: role in DNA replication and beyond.
Tuteja et al., New Delhi, India. In Plant Mol Biol, 2011
This overview of MCMs contains an emphasis on MCMs from plants and the novel role of MCM6 in abiotic stress tolerance.
The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells.
Liang et al., Hong Kong, Hong Kong. In Cell Cycle, 2011
Results indicate that the interaction between hCdt1 and hMcm6 through their interacting domains is key for hCdt1 in facilitating the MCM hetero-hexamer to load onto chromatin for replication licensing.
The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.
Schwacha et al., Pittsburgh, United States. In Nucleic Acids Res, 2010
The Mcm ATPase active sites that flank Mcm2/5 (i.e. Mcm5/3 and 6/2) modulate the biochemical activities of the putative Mcm2/5 gate.
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
Zhu et al., Shanghai, China. In J Biol Chem, 2010
the molecular mechanism of Mcm2-7 chromatin loading and prereplicative complex assembly.
The prevalence of lactose intolerance (adult hypolactasia) in a randomly selected New Zealand population.
George et al., In N Z Med J, 2010
The numbers of the three genotypic combinations reveal that the percentage of this population that is genetically lactose intolerant is 8.23% and that the allele frequencies found are consistent with the expected Mendelian distribution.
The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function.
Davey et al., London, Canada. In Bmc Biochem, 2009
The minimal functional unit of Mcm4/6/7 is a hexamer.
Notch and minichromosome maintenance (MCM) proteins: integration of two ancestral pathways in cell cycle control.
Karsan et al., Houston, United States. In Cell Cycle, 2006
It has recently been shown that activated Notch downregulates mini-chromosome-maintenance (MCM) proteins MCM2 and MCM6 by a CSL-dependent mechanism.
Molecular genetics of adult-type hypolactasia.
Järvelä, Helsinki, Finland. In Ann Med, 2004
The C/T-13910 variant is located in a non-coding region in the genome in intron 13 of the minichromosome maintenance type 6 gene (MCM6).
Genetics of lactase persistence and lactose intolerance.
Swallow, London, United Kingdom. In Annu Rev Genet, 2002
This single nucleotide polymorphism is located 14 kb upstream from the start of transcription of lactase in an intron of the adjacent gene MCM6.
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