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Minichromosome maintenance complex component 5

MCM5, CDC46, bob1, DNA replication licensing factor, nda4
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MCM2, PCNA, CAN, MCM4, POLYMERASE
Papers on MCM5
Primary Cutaneous Follicle Center Lymphomas Expressing BCL2 Protein Frequently Harbor BCL2 Gene Break and May Present 1p36 Deletion: A Study of 20 Cases.
Ortonne et al., Créteil, France. In Am J Surg Pathol, Jan 2016
To investigate these issues and to further characterize PCFCL, we studied a series of 25 CFLs without any extracutaneous disease at diagnosis, selected on the basis of BCL2 protein expression using 2 BCL2 antibodies (clones 124 and E17) and BOB1/BCL2 double immunostaining.
Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin.
Savage et al., San Marcos, United States. In Comp Biochem Physiol C Toxicol Pharmacol, Dec 2015
Exposure to FL also resulted in down-regulated transcription of many genes involved with cell cycle progression (e.g., cdc20, cdc45, cdca7b, plk1, cdk1, ccnb-3, and cdca7a) and chromosome segregation (e.g., cenpe, cenpf, cenpi, cenpk, cenpo, cenpp, and cenpu; cep70; knstrm, kntc, mcm2, mcm5; smc2).
Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation.
Dedon et al., Albany, United States. In Plos Genet, Dec 2015
Here we use quantitative proteomics to show a direct link between wobble uridine 5-methoxycarbonylmethyl (mcm5) and 5-methoxy-carbonyl-methyl-2-thio (mcm5s2) modifications catalyzed by tRNA methyltransferase 9 (Trm9) in tRNAArg(UCU) and tRNAGlu(UUC) and selective translation of proteins from genes enriched with their cognate codons.
Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.
Reinberg et al., New York City, United States. In Mol Cell, Dec 2015
It associates with the regulatory MCM5 subunit of the replicative helicase.
Structure of the eukaryotic MCM complex at 3.8 Å.
Gao et al., Beijing, China. In Nature, Sep 2015
This narrow passageway, reinforced by the offset of the two single hexamers at the double hexamer interface, is flanked by two pairs of gate-forming subunits, MCM2 and MCM5.
The gene expression profile of resistant and susceptible Bombyx mori strains reveals cypovirus-associated variations in host gene transcript levels.
Gong et al., Suzhou, China. In Appl Microbiol Biotechnol, Jun 2015
Some of these genes were related and formed a large network, in which the genes for B. mori cuticular protein RR-2 motif 123 (BmCPR123) and the gene for B. mori DNA replication licensing factor Mcm2-like (BmMCM2) were key genes among the common up-regulated DEGs, whereas the gene for B. mori heat shock protein 20.1 (Bmhsp20.1)
A Taxonomic Revision of the Wallemia sebi Species Complex.
Gunde-Cimerman et al., Ljubljana, Slovenia. In Plos One, 2014
In this study, multi-locus phylogenetic analyses, using the internal transcribed spacer (ITS) regions, DNA replication licensing factor (MCM7), pre-rRNA processing protein (TSR1), RNA polymerase II largest subunit (RPB1), RNA polymerase II second largest subunit (RPB2) and a new marker 3´-phosphoadenosine-5´-phosphatase (HAL2), confirmed the previous hypothesis that W. sebi presents a complex of at least four species.
Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents.
Danilov et al., Portland, United States. In Cell Death Dis, 2014
Treatment of the CD40-stimulated CLL cells with MLN4924 resulted in deregulation of Cdt1, a DNA replication licensing factor, and cell cycle inhibitors p21 and p27.
Craniosynostosis, anal anomalies, and porokeratosis (CDAGS syndrome): case report and literature review.
Mégarbané et al., Beirut, Lebanon. In Eur J Med Genet, 2013
Molecular analysis of the c16orf57, RECQL4 and MCM5 genes was normal.
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.
Westermann et al., Heidelberg, Germany. In Cell Death Differ, 2011
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.
MCM-2 and MCM-5 expression in gastric adenocarcinoma: clinical significance and comparison with Ki-67 proliferative marker.
Theocharis et al., Athens, Greece. In Dig Dis Sci, 2011
MCM-5 expression was significantly associated with tumor size, presence of lymph node metastases and tumor histopathological stage. Patients with high MCM-5 expression had significantly shorter survival times.
Minichromosome maintenance (MCM) and AgNOR proteins expression in desmoid tumours: a tissue microarray analysis.
Sygut et al., Łódź, Poland. In Folia Histochem Cytobiol, 2010
lack of MCM5 proteins expression which may explain commonly known low mitotic activity of desmoid tumour cells
The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.
Schwacha et al., Pittsburgh, United States. In Nucleic Acids Res, 2010
The Mcm ATPase active sites that flank Mcm2/5 (i.e. Mcm5/3 and 6/2) modulate the biochemical activities of the putative Mcm2/5 gate.
B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology.
Cabras et al., Milano, Italy. In Hum Pathol, 2010
Alternatively, these cases may resemble primary mediastinal large B-cell lymphoma but contain tumor cells resembling Reed-Sternberg cells and displaying an aberrant phenotype such as CD20(-), CD15(-/+) CD45(+), CD30(+), Pax5(+), OCT2(+/-), and BOB1(+/-).
DNA replication, development and cancer: a homeotic connection?
Biamonti et al., Pisa, Italy. In Crit Rev Biochem Mol Biol, 2010
Moreover, Hox proteins interact with geminin, a regulator of cell cycle progression, and control the interaction of this protein with the DNA replication licensing factor Ctd1. Thus, the homeotic proteins, by participating directly in the function of DNA replication origins, may provide a direct link between the accurate regulation of DNA replication required by the morphogenetic program and the deregulation of this process typical of cancer.
Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.
Dyrskjøt et al., Århus, Denmark. In Bmc Cancer, 2009
Could use the urinary hTERT, SENP1, PPP1CA, and MCM5 mRNA to detect bladder cancer recurrence.
Hodgkin-like lymphoma, simulating anaplastic large cell lymphoma in the patient after renal transplantation--unusual case report and literature review.
Pileri et al., Warsaw, Poland. In Pol J Pathol, 2007
Then, additional stains with BOB1 and Oct2 were performed, which were positive.
New transcription factors in diagnostic hematopathology.
Doglioni et al., Milano, Italy. In Adv Anat Pathol, 2007
In this review we will consider the basic biologic aspects and the applications in hematopathology of some of the lymphocyte-related TFs, including Pax5/BSAB, MUM1/IRF4, BOB1, Oct-2, T-bet, and FOXP3.
MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells.
Laskey et al., Cambridge, United Kingdom. In Nature, 1995
A family of related yeast replication proteins, MCM2, 3 and 5 (also called, after cell-division cycle, CDC46), resemble licensing factor, entering the nucleus only during mitosis.
Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor.
Nojima et al., Ōsaka, Japan. In Cell, 1995
Cloning and sequencing of the cDNAs encoding the Xenopus and human proteins revealed that they are homologs of yeast Mcm3, a putative yeast DNA replication licensing factor.
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