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Minichromosome maintenance complex component 4

MCM4, cdc21, TMP1, 19 g
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MCM2, CAN, PCNA, MCM6, MCM5
Papers using MCM4 antibodies
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Nelson Jay A., In PLoS Pathogens, 2001
... (Neomarkers), α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 ...
Papers on MCM4
Concerted activities of Mcm4, Sld3 and Dbf4 in control of origin activation and DNA replication fork progression.
Stillman et al., Spring, United States. In Genome Res, Feb 2016
Mcm4, a helicase subunit, possesses an unstructured regulatory domain that mediates control from multiple kinase signaling pathways, including the Dbf4-dependent Cdc7 kinase (DDK).
HPV-type-specific response of cervical cancer cells to cisplatin after silencing replication licensing factor MCM4.
Narayan et al., Benares, India. In Tumour Biol, Dec 2015
In this study, we depleted MCM4, one of the MCM 2-7 complex components by RNA interference (RNAi) in four cervical cancer cell lines.
A novel homozygous insertion and review of published mutations in the NNT gene causing familial glucocorticoid deficiency (FGD).
van Ravenswaaij-Arts et al., Groningen, Netherlands. In Eur J Med Genet, Dec 2015
FGD is a heterogeneous disorder for which causal mutations have been identified in MC2R, MRAP, MCM4 and TXNRD2.
The chemical properties and microbial community characterization of the thermophilic microaerobic pretreatment process.
Guo et al., Qingdao, China. In Bioresour Technol, Dec 2015
Compared with thermophilic treatment under anaerobic condition (TMP0), cellulase activity obviously improved under microaerobic condition (TMP1), which was 10.9-49.0%
c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication.
Kumar et al., New Delhi, India. In Biochim Biophys Acta, Nov 2015
Here we show that ETS transcription factors are novel regulators of MCM4 origin, whose binding sites are localized between two divergently transcribing MCM4 and PRKDC genes.
Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer.
Dixon et al., London, United Kingdom. In J Clin Oncol, Aug 2015
RESULTS: The molecular response to letrozole was characterized and a four-gene classifier of clinical response was established (accuracy of 96%) on the basis of the level of two genes before treatment (one gene [IL6ST] was associated with immune signaling, and the other [NGFRAP1] was associated with apoptosis) and the level of two proliferation genes (ASPM, MCM4) after 2 weeks of therapy.
Genetic forms of adrenal insufficiency.
Auchus et al., In Endocr Pract, Apr 2015
ABBREVIATIONS: AAA = Allgrove syndrome (alachrima-achalasiaadrenal insufficiency) ACTH = adrenocorticotropic hormone AHC = adrenal hypoplasia congenita ALD = adrenoleukodystrophy CAH = congenital adrenal hyperplasia DAX1 = dosage-sensitive sex reversal, adrenal hypoplasia congenita, X-chromosome FGD = familial glucocorticoid deficiency LCAH = lipoid CAH MCM4 = mini-chromosome maintenancedeficient 4 SF1 = steroidogenic factor 1 VLCFA = very-long-chain fatty acid.
Primary Immunodeficiencies Associated with EBV Disease.
Cohen, Bethesda, United States. In Curr Top Microbiol Immunol, 2014
These include diseases due to mutations in PIK3CD, PIK3R1, CTPS1, STK4, GATA2, MCM4, FCGR3A, CARD11, ATM, and WAS.
Managing Single-Stranded DNA during Replication Stress in Fission Yeast.
Forsburg et al., Toronto, Canada. In Biomolecules, 2014
Another category of helicase mutant (mcm4-degron) causes fork stalling in early S-phase due to immediate loss of helicase function.
Ketoreductase TpdE from Rhodococcus jostii TMP1: characterization and application in the synthesis of chiral alcohols.
Meškys et al., Vilnius, Lithuania. In Peerj, 2014
Here, we report on the characterization of a ketoreductase TpdE from Rhodococcus jostii TMP1 that is a prospective tool for the synthesis of such compounds.
Novel insight into etiology, diagnosis and management of primary adrenal insufficiency.
Flück et al., Praha, Czech Republic. In Horm Res Paediatr, 2013
MCM4 mutations were found in a variant of FGD in an Irish travelling community manifesting with PAI, short stature, microcephaly and recurrent infections.
Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.
Kwon et al., Pusan, South Korea. In Mol Cell Biochem, 2012
Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2-p53-Cdc25A-p21-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis.
Recessive mutations in MCM4/PRKDC cause a novel syndrome involving a primary immunodeficiency and a disorder of DNA repair.
Ennis et al., Dublin, Ireland. In J Med Genet, 2012
Mutations in MCM4/PRKDC represent a novel cause of DNA breakage and NK cell deficiency.
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.
Jouanguy et al., Paris, France. In J Clin Invest, 2012
partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency
MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.
Metherell et al., London, United Kingdom. In J Clin Invest, 2012
MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency
Ploidy dictates repair pathway choice under DNA replication stress.
Tye et al., Ithaca, United States. In Genetics, 2011
A defective MCM helicase causes genetic instability only in particular cell types.
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4.
Stillman et al., New York City, United States. In Nature, 2010
studies establish that the eukaryote-specific NSD of Mcm4 has evolved to integrate several protein kinase regulatory signals for progression through S phase
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.
Schimenti et al., Minneapolis, United States. In Nat Genet, 2007
Hypomorphic alleles of Mcm4 may increase breast cancer risk.
A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast.
Nasmyth et al., Vienna, Austria. In Nature, 1992
MCBs are both necessary and sufficient for the late G1-specific transcription of the TMP1 thymidylate synthase and POL1 DNA polymerase genes.
Mitochondrial DNA synthesis in cell cycle mutants of Saccharomyces cerevisiae.
Fangman et al., In Cell, 1975
In cdc8 and cdc21, mutants defective in continued replication during the S phase of the cell cycle, mitochondrial DNA replication ceases at the nonpermissive temperature.
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