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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Mutated in colorectal cancers

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, SET, APC
Papers using MCC antibodies
Spinophilin participates in information transfer at immunological synapses
Mellman Ira et al., In The Journal of Cell Biology, 2003
... CD4+ T cells were prepared from lymph nodes or spleen of OT-I, OT-II (ovalbumin), and AND (MCC peptide) mice, respectively, using negative selection (Miltenyi Biotec).
T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation
Davis Mark M. et al., In The Journal of Cell Biology, 2001
... 5C.C7 and 2B4 primary T cell blasts were generated by adding 10 μM MCC (88–103) peptide to lymph node suspensions from TCR transgenic mice and used 7–12 ...
Papers on MCC
Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.
Hayashi et al., Yonago, Japan. In Hum Pathol, Feb 2016
Merkel cell carcinoma (MCC) is a clinically aggressive neuroendocrine skin cancer; 80% of the cases are associated with the Merkel cell polyomavirus (MCPyV).
Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma.
Lino-Silva et al., Mexico. In Int J Surg Pathol, Feb 2016
BACKGROUND: Recent reviews have referred to the paranuclear dot-like staining pattern of CD99 in several neoplasms, including solid pseudopapillary tumors in the pancreas, colonic adenocarcinomas, and colonic adenomas as well as in Merkel cell carcinoma (MCC).
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Choi et al., New York City, United States. In Nat Med, Feb 2016
Frataxin-deficient mice, which had higher mitochondrial iron loading, showed impaired airway mucociliary clearance (MCC) and higher pulmonary inflammation at baseline, whereas mice deficient in the synthesis of cytochrome c oxidase, which have reduced COX, were protected from CS-induced pulmonary inflammation and impairment of MCC.
Dobbs et al., Ames, United States. In Pac Symp Biocomput, Dec 2015
In 5-fold cross validation experiments, our method, PS-PRIP, achieved 92% Specificity and 61% Sensitivity, with a Matthews correlation coefficient (MCC) of 0.58 in predicting RNA-binding sites in proteins.
Effect of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against human Merkel cell carcinoma MKL-1 cells.
Wu et al., Wuhan, China. In Oncol Lett, Dec 2015
UNASSIGNED: Merkel cell carcinoma (MCC) is an aggressive skin cancer with an increasing incidence.
Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program.
Roy et al., Singapore, Singapore. In Curr Biol, Dec 2015
For example, metachronal beating of MCC cilia in the mammalian airways clears mucus that traps inhaled pathogens and pollutants.
Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer.
Dirix et al., Antwerp, Belgium. In Expert Opin Biol Ther, May 2015
INTRODUCTION: Ado- trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate composed of trastuzumab, a stable linker (MCC), and the cytotoxic agent DM1 (derivative of maytansine; mertansine).
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.
Pines et al., Cambridge, United Kingdom. In Nature, Mar 2015
The SAC prevents the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase from recognizing cyclin B and securin by catalysing the incorporation of the APC/C co-activator, CDC20, into a complex called the mitotic checkpoint complex (MCC).
Therapeutic options for hydrating airway mucus in cystic fibrosis.
Rogers et al., London, United Kingdom. In Pharmacology, 2014
PCL layer dehydration reduces mucociliary clearance (MCC), leading to airway obstruction (reduced airflow and inflammation due to pathogen invasion) with mucus plug formation.
Ado-trastuzumab emtansine: a HER2-positive targeted antibody-drug conjugate.
Lowe et al., Richmond, United States. In Ann Pharmacother, 2014
DATA SOURCES: Sources of information were identified through a PubMed search (1966 to June 2014) using the key terms ado-trastuzumab emtansine, trastuzumab-DM1, trastuzumab-MCC-DM1, and T-DM1.
Merkel cell carcinoma: is this a true carcinoma?
Czajkowski et al., Bydgoszcz, Poland. In Exp Dermatol, 2014
Recent years have brought an enhanced understanding of Merkel cell carcinoma (MCC) biology, especially with regard to the Merkel cell polyoma virus as a causative agent.
Mutational analysis of merkel cell carcinoma.
Jr et al., Boston, United States. In Cancers (basel), 2013
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy that is associated with a poor prognosis.
The spindle assembly checkpoint works like a rheostat rather than a toggle switch.
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2013
The SAC generates a mitotic checkpoint complex (MCC) to prevent the anaphase-promoting complex/cyclosome (APC/C) from targeting key mitotic regulators for destruction until all of the chromosomes have attached to the mitotic apparatus.
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.
Faulkner et al., Edinburgh, United Kingdom. In Cell, 2013
In the first example, 4/19 (21.1%) donors presented germline retrotransposition events in the tumor suppressor mutated in colorectal cancers (MCC).
Loss of heterozygosity of the Mutated in Colorectal Cancer gene is not associated with promoter methylation in non-small cell lung cancer.
Kohonen-Corish et al., Sydney, Australia. In Lung Cancer, 2012
we have shown that promoter methylation of the APC gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.
The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells.
Kohonen-Corish et al., Sydney, Australia. In Biochim Biophys Acta, 2012
MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex.
Structure of the mitotic checkpoint complex.
Barford et al., London, United Kingdom. In Nature, 2012
The SAC is imposed by the mitotic checkpoint complex (MCC), whose assembly is catalysed by unattached chromosomes and which binds and inhibits the anaphase-promoting complex/cyclosome (APC/C), the E3 ubiquitin ligase that initiates chromosome segregation.
Mutated in colorectal cancer protein modulates the NFκB pathway.
Kohonen-Corish et al., Sydney, Australia. In Anticancer Res, 2012
Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.
Association of APC and MCC polymorphisms with increased breast cancer risk in an Indian population.
Panda et al., Calcutta, India. In Int J Biol Markers, 2011
observed a significant association of the rs11283943 SNP with increased breast cancer risk in an Indian population
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.
Lécine et al., Marseille, France. In Febs Lett, 2009
Results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2.
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