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Melanocortin 5 receptor

MC5R, MC2, hMC5R, melanocortin 5 receptor
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: MC3R, proopiomelanocortin, MC4R, ACTH receptor, ACID
Papers on MC5R
TiC2: a new two-dimensional sheet beyond MXenes.
Wang et al., Beijing, China. In Nanoscale, Jan 2016
When Ti is replaced with other transition metal centers, diverse new MC2 sheets containing C[double bond, length as m-dash]C dimers can be formed, the properties of which merit further investigation.
Differential expression of feeding-related hypothalamic neuropeptides in the first generation of quails divergently selected for low or high feed efficiency.
Dridi et al., Fayetteville, United States. In Neuropeptides, Jan 2016
Indeed, the expression of NPY, POMC, CART, CRH, melanocortin system (MC1R, MC2R, MC4R, MC5R), ORX, mTOR and ACCα was significantly decreased, however ORXR1/2, AMPKα1, S6K1 and STAT1, 5 and 6 were increased in high compared to low FE males (P<0.05).
Exploring the efficacy of wastewater-grown microalgal biomass as a biofertilizer for wheat.
Nain et al., Chandīgarh, India. In Environ Sci Pollut Res Int, Jan 2016
The present investigation was undertaken to evaluate two formulations (formulation with unicellular microalgae (MC1) and formulation with filamentous microalgae (MC2); T4 and T5, respectively), prepared using wastewater-grown microalgal biomass, as a biofertilizer (after mixing with vermiculite/compost as a carrier) in wheat crop (Triticum aestivum L. HD2967) under controlled conditions.
A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist.
Haskell-Luevano et al., Minneapolis, United States. In Bioorg Med Chem Lett, Dec 2015
Partial receptor activation was observed for the MC3R and MC5R at 100μM concentrations.
Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane.
Hinkle et al., Rochester, United States. In J Biol Chem, Dec 2015
The melanocortin-2 (MC2) receptor is a G protein-coupled receptor that mediates responses to ACTH.
Association Between MC-2 Peptide and Hepatic Perfusion and Liver Injury Following Resuscitated Hemorrhagic Shock.
Garrison et al., Louisville, United States. In Jama Surg, Dec 2015
Objective: To examine whether MC-2 would bind glycosaminoglycans to decrease proinflammatory cytokines' influence in the liver, minimize organ edema, prevent liver injury, and improve hepatic perfusion.
Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes.
Wulff et al., Denmark. In Bmc Res Notes, 2014
RESULTS: Non-selective MCR agonist α-MSH, MC5R-selective agonist PG-901 and MC4R-selective agonist LY2112688 significantly stimulated lipolysis in intact white adipose tissue, whereas stimulation of MCRs in differentiated adipocytes failed to do so.
Biphasic effect of melanocortin agonists on metabolic rate and body temperature.
Reitman et al., Bethesda, United States. In Cell Metab, 2014
This is preceded by a profound, transient hypometabolism/hypothermia that is preserved in mice lacking any one of Mc1r, Mc3r, Mc4r, or Mc5r.
Molecular evolution of GPCRs: Melanocortin/melanocortin receptors.
Lesinski et al., Akron, United States. In J Mol Endocrinol, 2014
melanocortin 1 receptor (MC1R), pigmentation regulation; MC2R, glucocorticoid synthesis; MC3R and MC4R, energy homeostasis; and MC5R, exocrine gland physiology).
Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome.
Gragnoli, Philadelphia, United States. In Appl Clin Genet, 2013
We hypothesize that HPA axis hyperactivation may be due to variants in the genes of the CRH receptors (CRHR1, CRHR2), corticotropin receptors (or melanocortin receptors, MC1R-MC5R), glucocorticoid receptor (NR3C1), mineralocorticoid receptor (NR3C2), and of the FK506 binding protein 51 (FKBP5), and that these variants may be partially responsible for the clinical association of depression, T2D and MetS.
Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.
Salamon et al., Poznań, Poland. In J Appl Genet, 2013
Three genes (MC2R, MC4R and MC5R) are syntenic in the human, mouse, cattle and dog genomes, while in the pig, the syntenic group comprises MC1R, MC2R and MC5R.
Melanocortin receptor accessory proteins in adrenal gland physiology and beyond.
Chan et al., London, United Kingdom. In J Endocrinol, 2013
The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R) with diverse physiological roles.
Leung, Bethesda, United States. In Unknown Journal, 2013
There are five MC receptors (MC1R to MC5R), which belong to the G-protein−coupled receptor superfamily (5).
Melanocortin receptors 1 and 5 might mediate inhibitory effects of α-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
Yamashita et al., In J Invest Dermatol, 2012
Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved.
Wulff et al., Denmark. In Mol Cell Endocrinol, 2011
melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes
A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids.
Seiberg et al., United States. In J Dermatol Sci, 2011
Data suggest that antagonists of MC1R and MC5R could be effective inhibitors of sebaceous gland differentiation and the production of sebum-specific lipids.
Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen.
Taylor et al., Boston, United States. In Invest Ophthalmol Vis Sci, 2010
Dependence on MC5r expression promotes or selectively activates IRBP-specific FoxP3+ TGF-beta+ CD25+CD4+ Treg cells in the spleens of experimental uveitis-recovered mice.
Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes.
Kim et al., South Korea. In J Mol Endocrinol, 2010
Data show that melanocortins regulate Il6 gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
World Year of Physics: a direct test of E=mc2.
Pritchard et al., Cambridge, United States. In Nature, 2006
Einstein's relationship is separately confirmed in two tests, which yield a combined result of 1-Delta(mc2)/E=(-1.4+/-4.4)x10(-7),
Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides.
Cone et al., Portland, United States. In Cell, 1998
Identification of a widely distributed receptor for ACTH/MSH peptides, the melanocortin-5 receptor (MC5-R), suggested non-steroidally mediated systemic effects of these peptides.
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