gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Melanocortin 4 receptor

MC4R, melanocortin-4 receptor
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: fibrillin-1, HAD, FTO, leptin, AGE
Papers on MC4R
Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group.
Pepper et al., Pretoria, South Africa. In Mol Genet Genomic Med, Jan 2016
Mutations in the melanocortin 4 receptor (MC4R) gene, which codes for a G-protein-coupled receptor responsible for postprandial satiety signaling, have been associated with monogenic obesity.
Growth, carcass and meat quality traits in beef from Angus, Hereford and cross-breed grazing steers, and their association with SNPs in genes related to fat deposition metabolism.
Villarreal et al., Buenos Aires, Argentina. In Meat Sci, Jan 2016
Breed effects were studied, and the association of SNPs with fat deposition and fatty acid (FA) composition (leptin, melanocortin-4 receptor, stearoyl-CoA desaturase, FA synthase and thyroglobulin) was tested.
Effect of interactions of polymorphisms in the Melanocortin-4 receptor gene with dietary factors on the risk of obesity and Type 2 diabetes: a systematic review.
Mirmiran et al., Tehrān, Iran. In Diabet Med, Jan 2016
AIM: To perform a systematic review of the effect of interaction between Melanocortin-4 receptor (MC4R) single nucleotide polymorphisms and diet on the development of obesity and Type 2 diabetes.
Genetic and biochemical characteristics in the Roma minority in the South Bohemia Region.
Šedová et al., Praha, Czech Republic. In Neuro Endocrinol Lett, Jan 2016
The difference in BMI and weight was found to be associated with the MC4R gene.
The elegance of energy balance: Insight from circuit-level manipulations.
Krashes et al., Baltimore, United States. In Synapse, Sep 2015
These include neurons that express agouti-related peptide, pro-opiomelanocortin, single-minded homolog 1 protein, and the melanocortin-4 receptor.
Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein.
Dunigan et al., Atlanta, United States. In Neurosci Biobehav Rev, Sep 2015
The melanocortin system of the hypothalamus, including the neuropeptides α-melanocyte stimulating hormone (αMSH) and agouti-related protein (AgRP), and their receptors, the melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R), have been well-studied for their roles in the central control of feeding and body weight.
Diet-induced obese mice retain endogenous leptin action.
Perez-Tilve et al., Cincinnati, United States. In Cell Metab, Jul 2015
The antagonist increased feeding and body weight (BW) in lean mice, but not in obese models of leptin, leptin receptor, or melanocortin-4 receptor deficiency.
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Cone et al., Nashville, United States. In Nature, May 2015
Both peptides bind with high affinity to the melanocortin-4 receptor (MC4R); existing data show that α-MSH is an agonist that couples the receptor to the Gαs signalling pathway, while AgRP binds competitively to block α-MSH binding and blocks the constitutive activity mediated by the ligand-mimetic amino-terminal domain of the receptor.
Role of melanocortin signalling in the preference for dietary macronutrients in human beings.
Farooqi et al., Cambridge, United Kingdom. In Lancet, Mar 2015
BACKGROUND: Signalling though the melanocortin 4 receptor (MC4R), which is widely expressed in the hypothalamus, mediates food intake and macronutrient preference in rodents.
The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
Cone et al., Nashville, United States. In Cell Metab, 2015
The melanocortin-4 receptor (MC4R) is expressed in the brainstem and vagal afferent nerves and regulates a number of aspects of gastrointestinal function.
Enteroendocrine MC4R and energy balance: linking the long and the short of it.
Batterham et al., London, United Kingdom. In Cell Metab, 2015
Central MC4R pathways are well established as integrators of peripheral signals in the control of energy balance.
Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.
Gilbert-Diamond et al., United States. In Biodata Min, 2014
In this study, we aimed to analyze pairwise interactions that are associated with Body Mass Index (BMI) between SNPs from twelve genes robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18).
Role of Syndecans in Lipid Metabolism and Human Diseases.
Galzitskaya et al., Moscow, Russia. In Adv Exp Med Biol, 2014
Syndecan-3 helps co-localize the appetite-regulating melanocortin-4 receptor with its agonist, leading to an increased appetite.
Weight Gain and Metabolic Changes During Treatment with Antipsychotics and Antidepressants.
Kirkby et al., Leipzig, Germany. In Endocr Metab Immune Disord Drug Targets, 2014
Recently discovered pathophysiological mechanisms include antihistaminergic effects, activation of hypothalamic adenosine monophosphate-activated protein kinase (AMPK), modulation of hormonal signaling of ghrelin and leptin, changes in the production of cytokines such as tumor necrosis factor-alpha (TNF)-alpha and adipokines such as adiponektin, and the impact of genes, in particular the melanocortin 4 receptor (MC4R), serotonin 2C receptor (HTR2C), leptin, neuropeptide Y (NPY) and cannabinoid receptor 1 (CNR1) genes.
Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study.
Tungtrongchitr et al., Bangkok, Thailand. In Genet Mol Res, 2014
MC3R (melanocortin-3 receptor) and MC4R (melanocortin-4 receptor) play important roles in energy homeostasis.
Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.
Kennedy et al., United States. In Arch Gen Psychiatry, 2012
These data implicate MC4R in extreme SGA-induced weight gain and related metabolic disturbances.
Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens.
Malenka et al., Stanford, United States. In Nature, 2012
chronic stress in mice decreases the strength of excitatory synapses on D1 dopamine receptor-expressing nucleus accumbens medium spiny neurons owing to activation of the melanocortin 4 receptor
Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats.
Seeley et al., Cincinnati, United States. In Am J Physiol Endocrinol Metab, 2012
Data from heterozygote/homozygote rats for Mc4r mutation suggest that Mc4r has role in development of obesity, but Mc4r does not have a role in weight loss or glucose metabolism/glucose intolerance following bariatric vertical sleeve gastrectomy.
Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH).
Baldini et al., Little Rock, United States. In J Biol Chem, 2012
Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to alpha-melanocyte-stimulating hormone (alpha-MSH)
Prevalence of melanocortin receptor 4 (MC4R) V103I gene variant and its association with obesity among the Kampar Health Clinic cohort, Perak, Malaysia.
Say et al., Kampar, Malaysia. In Med J Malaysia, 2012
Prevalence of the MC4R gene variant among the Malaysian cohort was similar with previous populations (2-4% of mutated allele carrier), but was not associated with obesity.
share on facebooktweetadd +1mail to friends