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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Melanocortin 3 receptor

MC3R, MC3, melanocortin-3 receptor, hMC3R
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MC4R, proopiomelanocortin, HAD, MC5R, AGRP
Papers using MC3R antibodies
Dual functions of α4β1 integrin in epicardial development
Yang Joy T. et al., In The Journal of Cell Biology, 1994
... The linearized plasmid was electroporated into MC3 embryonic stem (ES) cells, generated and provided by the Johns Hopkins University School of Medicine (Baltimore, MD) transgenic facility ...
Papers on MC3R
Synthesis and Structure-Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors.
Haskell-Luevano et al., Minneapolis, United States. In Acs Chem Neurosci, Jan 2016
In particular, the melanocortin-3 and -4 receptors (MC3R/MC4R) have been demonstrated to regulate body weight, energy homeostasis, and feeding behavior.
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.
Grieco et al., Napoli, Italy. In J Med Chem, Jan 2016
In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands.
MC3R gene polymorphisms are associated with early childhood adiposity gain and infant appetite in an Asian population.
Lee et al., Singapore, Singapore. In Pediatr Obes, Jan 2016
BACKGROUND: Polymorphic variants within human melanocortin-3 receptor gene (MC3R) gene have been associated with obesity.
Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein.
Dunigan et al., Atlanta, United States. In Neurosci Biobehav Rev, Sep 2015
The melanocortin system of the hypothalamus, including the neuropeptides α-melanocyte stimulating hormone (αMSH) and agouti-related protein (AgRP), and their receptors, the melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R), have been well-studied for their roles in the central control of feeding and body weight.
[Evaluation of MC3 valve ring for management of functional tricuspid regurgitation].
Song et al., Zhengzhou, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
OBJECTIVE: To evaluate the clinical efficacy of tricuspid valve (TV) annuloplasty with MC3 valve ring for management of functional tricuspid regurgitation (FTR).
Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade.
Mountjoy, Auckland, New Zealand. In J Neuroendocrinol, Jun 2015
The present review focuses on evidence obtained over the past decade that has changed our understanding of POMC gene expression and regulation in the central nervous system, POMC and AgRP neuronal circuitry, neuroanatomical functions of melanocortin receptors, melanocortin 3 receptor (MC3R) and MC4R, and signal transduction through MC3R and MC4R.
Genetic association studies of obesity in Africa: a systematic review.
Kengne et al., Cape Town, South Africa. In Obes Rev, Mar 2015
Polymorphisms in genes such as ACE, ADIPOQ, ADRB2, AGRP, AR, CAPN10, CD36, C7orf31, DRD4, FTO, MC3R, MC4R, SGIP1 and LEP were found to be associated with various measures of obesity.
Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3).
Abizaid et al., Ottawa, Canada. In Eneuro, Mar 2015
These include the dopamine 1 receptor (D1R), the dopamine 2 receptor (D2R), the melanocortin-3 receptor (MC3R), the serotonin 2C receptor (5-HT2C), and possibly the cannabinoid type 1 receptor (CB1).
Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study.
Tungtrongchitr et al., Bangkok, Thailand. In Genet Mol Res, 2014
MC3R (melanocortin-3 receptor) and MC4R (melanocortin-4 receptor) play important roles in energy homeostasis.
Targeting central melanocortin receptors: a promising novel approach for treating alcohol abuse disorders.
Thiele et al., Chapel Hill, United States. In Front Neurosci, 2013
The MC3R and MC4R subtypes, the most abundant central MCRs, are widely expressed in brain regions known to modulate neurobiological responses to ethanol, including regions of the hypothalamus and extended amygdala.
Functional characterization of nine novel naturally occurring human melanocortin-3 receptor mutations.
Tao et al., Auburn, United States. In Biochim Biophys Acta, 2012
we provided detailed data of these novel human MC3R mutations leading to a better understanding of structure-function relationship of MC3R and the role of MC3R mutation in obesity
Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research.
Grässel et al., Münster, Germany. In Endocr Rev, 2012
MCR subtypes, especially MC1R, MC2R (the ACTH receptor), MC3R, and MC4R, but also the μ-OR and δ-OR, have been detected in various cells of the synovium, cartilage, and bone.
Melanocortin-3 receptors are involved in adaptation to restricted feeding.
Butler et al., Jupiter, United States. In Genes Brain Behav, 2012
The melanocortin-3 receptors are involved in regulating adaptation to food restriction.
Structural insight into the role of the human melanocortin 3 receptor cysteine residues on receptor function.
Harmon et al., Birmingham, United States. In Peptides, 2011
Extracellular cysteine residue C305, C311 and C313 are crucial for receptor expression and the transmembrane cysteine residue, C115 and 162 are important for ligand binding and signaling.
MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation?
Biebermann et al., Berlin, Germany. In Neuroendocrinology, 2011
Interaction of the melanocortin 3 receptor (MC3R) and the growth hormone secretagogue receptor (GHSR)-1a results in a modulation of function in both receptors.
Identification of the translation start site of the human melanocortin 3 receptor.
Biebermann et al., Berlin, Germany. In Obes Facts, 2011
The polymorphism T6K is not located in the coding region of the human MC3R and has no influence on translation initiation which makes an impact on body weight unlikely.
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction.
Mutulis et al., Uppsala, Sweden. In Nat Rev Drug Discov, 2008
In this Review, we first outline the physiological roles of the melanocortin system, then discuss the potential of targeting melanocortin receptors by using MC3 and MC4 agonists for treating weight disorders and sexual dysfunction, and MC4 antagonists to treat anorectic and cachectic conditions.
Targeting melanocortin receptors as a novel strategy to control inflammation.
Lipton et al., Milano, Italy. In Pharmacol Rev, 2004
Preclinical investigations indicate that activation of certain MCR subtypes, primarily MC1R and MC3R, could be a novel strategy to control inflammatory disorders.
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.
Van der Ploeg et al., Rahway, United States. In Nat Genet, 2000
The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has remained unknown.
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.
Cone et al., Portland, United States. In Nature, 1997
To test the hypothesis that agouti causes obesity by antagonism of hypothalamic melanocortin receptors, we identified cyclic melanocortin analogues that are potent agonists or antagonists of the neural MC3 (refs 11, 12) and MC4 receptors.
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