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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Mannose-binding lectin

MBL, mannose-binding lectin, mannan-binding lectin, MBL2
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, L-ficolin, ACID
Papers using MBL antibodies
A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations
Perkins Stephen J. et al., In The Journal of Biological Chemistry, 2004
... mannose-binding lectinMASPMBL-associated serine protease ...
Papers on MBL
Simultaneous pancreas-kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression.
Reinders et al., Leiden, Netherlands. In Diabetologia, Feb 2016
AIMS/HYPOTHESIS: High levels of circulating mannan-binding lectin (MBL) are associated with the development of diabetic nephropathy and hyperglycaemia-induced vasculopathy.
Genetic Variants That Are Associated with Neuropsychiatric Systemic Lupus Erythematosus.
Zhang et al., Singapore, Singapore. In J Rheumatol, Feb 2016
Case-control studies were chosen if they reported genotype frequencies of the γ Fc region (FCγR) receptors II-A, III-A, and III-B; tumor necrosis factor-α (TNF-α); mannan-binding lectin (MBL); integrin alpha M (ITGAM); interleukin (IL) 1, IL-1β, and IL-6; IL-10 promoter; and vitamin D genes.
Mosaic 13q14 deletions in peripheral leukocytes of non-hematologic cancer cases and healthy controls.
Chanock et al., Rockville, United States. In J Hum Genet, Feb 2016
UNASSIGNED: Loss of 13q14.3 is a chromosomal event found in ~50% of B-cell chronic lymphocytic leukemia (CLL) and monoclonal B-cell lymphocytosis (MBL) cases.
Mannose-binding lectin polymorphisms and rheumatoid arthritis: A short review and meta-analysis.
de Messias-Reason et al., Curitiba, Brazil. In Mol Immunol, Jan 2016
Mannose-binding lectin (MBL) is a pattern recognition receptor of the lectin pathway of complement system.
Murine models of Aspergillosis: Role of collectins in host defense.
Sarma et al., In Indian J Exp Biol, Nov 2015
Collectins, namely surfactant protein A (SP-A), surfactant protein D (SP-D) and mannan binding lectin (MBL), are pattern recognition molecules regulating both innate and adaptive immune response against pathogens.
A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens.
Bush, Bloomington, United States. In Int J Antimicrob Agents, Nov 2015
The aztreonam/avibactam combination demonstrates inhibitory activity against MBL-producing enteric bacteria owing to the stability of the monobactam to these enzymes, but resistance is still an issue for MBL-producing non-fermentative bacteria.
Effects of Sequence Variations in Innate Immune Response Genes on Infectious Outcome in Trauma Patients: A Comprehensive Review.
Van Lieshout et al., Rotterdam, Netherlands. In Shock, Nov 2015
The following genes have been studied in populations of trauma patients: CD14, HMGB1, IFNG, IL1A, IL1B, IL1RN, IL4, IL6, IL8, IL10, IL17F, IL18, MBL2, MASP2, FCN2, TLR1, TLR2, TLR4, TLR9, TNF, LTA, GR, MYLK, NLRP3, PRDX6, RAGE, HSPA1B, HSPA1L, HSP90, SERPINE1, IRAK1, IRAK3, VEGFA, LY96, ANGPT2, LBP, MicroRNA, and mtDNA.
Complement and membrane-bound complement regulatory proteins as biomarkers and therapeutic targets for autoimmune inflammatory disorders, RA and SLE.
Das, In Indian J Exp Biol, Nov 2015
The zymogens get activated in a cascade fashion by antigen-antibody complex, antigen alone or by polymannans, respectively, by the classical, alternative and mannose binding lectin (MBL) pathways.
Phenotypic determination of carbapenemase producing enterobacteriaceae isolates from clinical specimens at a tertiary hospital in Lagos, Nigeria.
Ettu et al., Lagos, Nigeria. In Niger Postgrad Med J, Oct 2015
Of the 22 isolates that were positive for carbapenemase production, 15 (8.5%) were metallo beta-lactamase (MBL) producers, 6 (3.4%) produced oxacillinase-48 while 1 (0.5%) produced both MBL and Klebsiella pneumoniae carbapenemase.
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.
Schofield et al., Bristol, United Kingdom. In Nat Chem, 2014
The use of β-lactam antibiotics is compromised by resistance, which is provided by β-lactamases belonging to both metallo (MBL)- and serine (SBL)-β-lactamase subfamilies.
Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil.
Pimentel et al., São Luís, Brazil. In Genet Mol Res, 2014
Mannose-binding lectin (MBL) is a protein that plays an important role in the innate immune system.
An extracorporeal blood-cleansing device for sepsis therapy.
Ingber et al., Boston, United States. In Nat Med, 2014
Blood flowing from an infected individual is mixed with magnetic nanobeads coated with an engineered human opsonin--mannose-binding lectin (MBL)--that captures a broad range of pathogens and toxins without activating complement factors or coagulation.
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance.
Wright et al., Hamilton, Canada. In Nature, 2014
Here we have identified a fungal natural product, aspergillomarasmine A (AMA), that is a rapid and potent inhibitor of the NDM-1 enzyme and another clinically relevant MBL, VIM-2.
MASP interactions with plasma-derived MBL.
Houen et al., Grenoble, France. In Mol Immunol, 2012
The interaction of mannan-binding lectin (MBL) with its associated serine proteases (MASPs) was investigated using recombinant (r) MBL, plasma-derived (pd) MBL, rMASP-3 and rMAp19. rMASP-3 and rMAp19 bound to free available sites on rMBL and pdMBL.
Urinary mannose-binding lectin is a biomarker for predicting the progression of immunoglobulin (Ig)A nephropathy.
Liu et al., Shenyang, China. In Clin Exp Immunol, 2012
urinary MBL can be a reliable non-invasive biomarker for evaluating disease severity and predicting the prognosis of IgAN.
MBL serum levels in patients with sepsis correlate with thyroid function but not with outcome.
Trendelenburg et al., In Clin Immunol, 2012
Even when adjusting for the thyroid function we could neither find an association of low plasma MBL levels with sepsis nor with the severity/outcome of sepsis in adult immunocompetent patients in the context of euthyroid sick syndrome
Genetic variants of the MBL2 gene are associated with mortality in pneumococcal sepsis.
Garnacho-Montero et al., Sevilla, Spain. In Diagn Microbiol Infect Dis, 2012
Study concludes variant alleles in the MBL2 gene are independently associated with in-hospital and medium-term mortalities in patients admitted to the hospital with pneumococcal sepsis.
Association of the wild-type A/A genotype of MBL2 codon 54 with asthma in a North Indian population.
Singla et al., Chandīgarh, India. In Dis Markers, 2011
MBL2 codon 54 A/B polymorphism is significantly associated with asthma
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.
Sonneveld et al., Rotterdam, Netherlands. In Lancet Oncol, 2010
Significant SNPs were noted in inflammatory genes MBL2 (OR 0·49, 95% CI 0·26-0·94; p=3·0×10(-2)) and PPARD (0·35, 0·15-0·83; p=9·1×10(-3)), and DNA repair genes ERCC4 (2·74, 1·56-4·84; p=1·0×10(-3)) and ERCC3 (1·26, 0·75-2·12; p=3·3×10(-3)).
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia.
Dalla-Favera et al., New York City, United States. In Cancer Cell, 2010
Deletions of the chromosomal region 13q14 are commonly associated with CLL, with monoclonal B cell lymphocytosis (MBL), which occasionally precedes CLL, and with aggressive lymphoma, suggesting that this region contains a tumor-suppressor gene.
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