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Endothelial differentiation-related factor 1

MBF1, Multiprotein bridging factor 1, EDF-1
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: TBP, ACID, SFRP1, CAN, LRH-1
Papers on MBF1
Overexpression of heat stress-responsive TaMBF1c, a wheat (Triticum aestivum L.) Multiprotein Bridging Factor, confers heat tolerance in both yeast and rice.
Sun et al., Beijing, China. In Plant Mol Biol, 2015
The deduced amino acid sequence revealed the presence of conserved MBF1 and helix-turn-helix domains at the N- and C-terminus, respectively, which were highly similar to rice ERTCA (Ethylene Response Transcriptional Co-Activator) and Arabidopsis MBF1c.
Interaction between TATA-Binding Protein (TBP) and Multiprotein Bridging Factor-1 (MBF1) from the Filamentous Insect Pathogenic Fungus Beauveria bassiana.
Keyhani et al., Beijing, China. In Plos One, 2014
Multiprotein bridging factor 1 (MBF1) is thought to interconnect TBP with gene specific transcriptional activators, modulating transcriptional networks in response to specific signal and developmental programs.
Identification and Evaluation of Reference Genes for Accurate Transcription Normalization in Safflower under Different Experimental Conditions.
Wu et al., Chengdu, China. In Plos One, 2014
These genes were ABCS, 60SRPL10, RANBP1, UBCL, MFC, UBCE2, EIF5A, COA, EF1-β, EF1, GAPDH, ATPS, MBF1, GTPB and GST.
Examining the virulence of Candida albicans transcription factor mutants using Galleria mellonella and mouse infection models.
Coste et al., Lausanne, Switzerland. In Front Microbiol, 2014
After filtering the results obtained from the two infection models, mutants for MBF1 and ZCF6 were selected.
Diverse expression pattern of wheat transcription factors against abiotic stresses in wheat species.
Unver et al., Kastamonu, Turkey. In Gene, 2014
bZIP, MBF1, WRKY, MYB and NAC transcription factor (TF) genes are the largest transcriptional regulators which are involved in growth, development, physiological processes, and biotic/abiotic stress responses in plants.
Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain.
van der Oost et al., Wageningen, Netherlands. In Biochem J, 2014
MBF1 (multi-protein bridging factor 1) is a protein containing a conserved HTH (helix-turn-helix) domain in both eukaryotes and archaea.
The transcriptional co-activator multiprotein bridging factor 1 from the fungal insect pathogen, Beauveria bassiana, mediates regulation of hyphal morphogenesis, stress tolerance and virulence.
Keyhani et al., Hangzhou, China. In Environ Microbiol, 2014
Genome-wide expression analyses during growth under unstressed and thermal stress conditions revealed global gene expression changes and a set of putative targets for MBF1 mediated gene expression control.
Reduced tolerance to abiotic stress in transgenic Arabidopsis overexpressing a Capsicum annuum multiprotein bridging factor 1.
Wang et al., China. In Bmc Plant Biol, 2013
One of the genes cloned from the subtraction was homologous to Solanum tuberosum MBF1 (StMBF1) encoding the coactivator multiprotein bridging factor 1. Here, we have characterized this StMBF1 homolog (named CaMBF1) from Capsicum annuum and investigated its role in abiotic stress tolerance.
EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during adipogenesis.
Kuri-Harcuch et al., Mexico. In Biochem Biophys Res Commun, 2013
The endothelial differentiation factor-1 (EDF-1) is a calmodulin binding protein that regulates calmodulin-dependent enzymes.
The Compass-like locus, exclusive to the Ambulacrarians, encodes a chromatin insulator binding protein in the sea urchin embryo.
Spinelli et al., Palermo, Italy. In Plos Genet, 2012
Furthermore, microinjection of the CMPl antiserum in combination with a synthetic mRNA encoding a forced repressor of the H2A enhancer-bound MBF1 factor restores the normal H1 mRNA abundance.
MBF1s regulate ABA-dependent germination of Arabidopsis seeds.
Godoy et al., Mar del Plata, Argentina. In Plant Signal Behav, 2012
Transcriptional co-activators of the multiprotein bridging factor 1 (MBF1) controls gene expression by connecting transcription factors and the basal transcription machinery.
Human multiprotein bridging factor 1 and Calmodulin do not interact in vitro as confirmed by NMR spectroscopy and CaM-agarose affinity chromatography.
Vignali et al., Cesena, Italy. In Protein Expr Purif, 2011
According to this study multiprotein bridging factor 1 and Calmodulin do not interact in vitro as confirmed by NMR spectroscopy and CaM-agarose affinity chromatography.
Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection.
Wang et al., Xiamen, China. In Dev Comp Immunol, 2011
To further confirm the up-regulation of differentially expressed genes, the semi-quantitative RT-PCR were performed to test twenty randomly selected genes, in which eight of the selected genes exhibited clear up-regulation upon WSSV infection in red claw crayfish Hpt cells, including DNA helicase B-like, multiprotein bridging factor 1, apoptosis-linked gene 2 and an unknown gene-L1635 from L1 library; coatomer gamma subunit, gabarap protein gene, tripartite motif-containing 32 and an unknown gene-L12-254 from L2 library, respectively.
Identification of the MBF1 heat-response regulon of Arabidopsis thaliana.
Mittler et al., Denton, United States. In Plant J, 2011
Here we report on the identification of a new heat-response regulon in plants controlled by the multiprotein bridging factor 1c (MBF1c) protein of Arabidopsis thaliana.
Transcriptional coactivator EDF-1 is required for PPARgamma-stimulated adipogenesis.
Maier et al., Milano, Italy. In Cell Mol Life Sci, 2009
EDF-1 is required for PPARgamma transcriptional activation during preadipocyte differentiation.
Role of multiprotein bridging factor 1 in archaea: bridging the domains?
van der Oost et al., Wageningen, Netherlands. In Biochem Soc Trans, 2009
MBF1 (multiprotein bridging factor 1) is a highly conserved protein in archaea and eukaryotes.
Compensatory change of interacting amino acids in the coevolution of transcriptional coactivator MBF1 and TATA-box-binding protein.
Gojobori et al., Mishima, Japan. In Mol Biol Evol, 2007
evidence for compensatory changes of transcription coactivator and its interacting target, presenting the report that transcription coactivator may have undergone coevolution with TBP
Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
Wittenberg et al., Los Angeles, United States. In Mol Cell, 2006
A negative feedback loop involving Nrm1 bound to MBF leads to transcriptional repression as cells exit G1 phase.
Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription.
Maier et al., Milano, Italy. In Gene, 2006
The EDF-1 minimal promoter was characterized.
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