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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

GPN-loop GTPase 1

MBD in, XAB1, GPN-1
This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, Parathyroid Hormone, fibrillin-1
Papers on MBD in
Structure of GPN-loop GTPase Npa3 and implications for RNA polymerase II assembly.
Cramer et al., Göttingen, Germany. In Mol Cell Biol, Jan 2016
Here we report the first crystal structure of a eukaryotic GPN-loop GTPase, the S. cerevisiae enzyme Npa3 (a homolog of human GPN1, also called RPAP4, XAB1, MBDin), and analyze its catalytic mechanism.
Genetic factors influencing the risk of multiple myeloma bone disease.
Morgan et al., Little Rock, United States. In Leukemia, Jan 2016
These findings will contribute to the development of future strategies for prevention of MBD in the early precancerous phases of MM.Leukemia advance online publication, 12 January 2016; doi:10.1038/leu.2015.342.
Burden of illness of bone metastases in prostate cancer patients in Québec, Canada: A population-based analysis.
Habib et al., Switzerland. In Can Urol Assoc J, Sep 2015
Effective therapy is needed to reduce the clinical and economic impact of MBD in this population.
Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate.
Tuñón et al., Madrid, Spain. In J Bone Miner Metab, Sep 2015
We studied the prevalence of mineral metabolism disorders, and the potential relationship between decreased estimated glomerular filtration rate (eGFR) and CKD-MBD in coronary artery disease patients in a cross-sectional study of 704 outpatients 7.5 ± 3.0 months after an acute coronary syndrome.
CKD-MBD spectrum at the time of initiation of hemodialysis in Pakistani chronic kidney disease patients.
Beg et al., Islamabad, Pakistan. In Saudi J Kidney Dis Transpl, Jul 2015
To determine the spectrum of CKD- MBD in the Pakistani population, we performed a retrospective review of the medical records of 63 native Pakistani CKD stage-5 patients at our unit at the initiation of hemodialysis from March 2009 to September 2011.
Bone kidney interactions.
Jamal et al., New York City, United States. In Rev Endocr Metab Disord, Jun 2015
More recently however our understanding of bone function in general and the role that bone plays in CKD-MBD in particular, has changed.
Management of CKD-MBD in non-dialysis patients under regular nephrology care: a prospective multicenter study.
Minutolo et al., Milano, Italy. In J Nephrol, Jun 2015
METHODS: We prospectively evaluated current management of CKD-MBD in two visits, performed 6 months apart, in 727 prevalent ND-CKD stage 3b-5 patients from 19 nephrology clinics.
Soluble Klotho and intact fibroblast growth factor 23 in long-term kidney transplant patients.
Gøransson et al., Bergen, Norway. In Eur J Endocrinol, Apr 2015
We assessed markers of MBD in patients with well-functioning kidney transplants to minimise confounding by reduced transplant function.
[New Developments in CKD-MBD. The management of posttransplant CKD-MBD : When, Who, and How?].
Fujii, United States. In Clin Calcium, 2014
In this article, I would like to explain the pathophysiology of post-transplant CKD-MBD and then to introduce a new role -- that not only transplant doctors, but also dialysis doctors, should play a crucial role in CKD-MBD in the post-transplant period.
[New Developments in CKD-MBD. Development and progression of CKD-MBD in predialysis period -when and how?].
Komaba, Funaishikawa, Japan. In Clin Calcium, 2014
Growing interest has been focused on the pathogenesis of chronic kidney disease-mineral and bone disorder (CKD-MBD) , which is not restricted to those with end-stage CKD and dialysis patients but also includes those with early-stage CKD.
The methyl-CpG-binding domain (MBD) is crucial for MeCP2's dysfunction-induced defects in adult newborn neurons.
Goh et al., Singapore, Singapore. In Front Cell Neurosci, 2014
To examine the role of MBD in the pathogenesis of RTT, we generated two MeCP2 mutant constructs, one with a deletion of MBD (MeCP2-ΔMBD), another mimicking a mutation of threonine 158 within the MBD (MeCP2-T158M) found in RTT patients.
Mammographic Breast Density in Chinese Women: Spatial Distribution and Autocorrelation Patterns.
Law et al., Xindi, China. In Plos One, 2014
The spatial distribution of MBD in the breast is variable and dependent on physiological, genetic, environmental and pathological factors.
Metabolic bone disease after renal transplantation.
Schüler et al., Hannover, Germany. In Curr Opin Pediatr, 2014
The purpose of this review is to give an overview of the pathogenesis and treatment of posttransplant MBD in children.
[Mineral and bone disorder in chronic kidney disease : Critical appraisal of pharmacotherapy].
Brunkhorst, Hannover, Germany. In Internist (berl), 2014
Pharmacological interventions for MBD in CKD are characterized by inconsistent data and a wide spectrum of (sometimes costly) treatment options.
A Japanese approach for CKD-MBD.
Fukagawa et al., Tokyo, Japan. In Kidney Int Suppl (2011), 2013
This article contains the new guideline text, and clinical significance of CKD-MBD in Japan.
A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export.
Sánchez-Olea et al., San Luis Potosí, Mexico. In Biochim Biophys Acta, 2012
A highly active, evolutionarily conserved nuclear export sequences in XAB1/Gpn1, was identified.
Human GTPases associate with RNA polymerase II to mediate its nuclear import.
Shiekhattar et al., Philadelphia, United States. In Mol Cell Biol, 2011
Data show that GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus.
The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II.
Coulombe et al., Montréal, Canada. In Mol Cell Proteomics, 2010
RPAP4/GPN1 is a member of a newly discovered GTPase family that contains a highly conserved GPN loop motif that is essential, along with its GTP-binding motifs, for nuclear localization of POLR2A/RPB1 in a process that also requires microtubule assembly
MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters.
Chiariotti et al., Napoli, Italy. In Mol Cell Biol, 2003
relieves MBD2-mediated transcriptional repression and reactivates transcription from methylated promoters
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