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Extended synaptotagmin-like protein 1

MBC2, E-Syt1, vp115, FAM62A
enriched in adipocyte plasma membranes and high density microsome fractions [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MBC1, Synaptotagmin II, HAD, Orai1, V1a
Papers on MBC2
Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering.
De Camilli et al., New Haven, United States. In Embo J, Oct 2015
By exposing semi-intact cells to buffers of variable Ca(2+) concentrations, we found that binding of E-Syt1 to the PI(4,5)P2-rich PM critically requires its C2C and C2E domains and that the EC50 of such binding is in the low micromolar Ca(2+) range.
Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum-plasma membrane contact sites.
De Camilli et al., New Haven, United States. In Proc Natl Acad Sci U S A, May 2015
E-Syt cytoplasmic domains comprise a synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain followed by five C2 domains in E-Syt1 and three C2 domains in E-Syt2/3.
Design and protocol of a randomized multiple behavior change trial: Make Better Choices 2 (MBC2).
Spring et al., Chicago, United States. In Contemp Clin Trials, Mar 2015
OBJECTIVE: The Make Better Choices 2 (MBC2) trial aims to examine whether sustained healthful diet and activity change are best achieved by targeting diet and activity behaviors simultaneously or sequentially.
Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes.
Nathanson et al., New Haven, United States. In Plos One, 2013
We found that rat hepatocytes express two of the three identified E-Syts (E-Syt1 and E-Syt2).
Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating.
Ahuja et al., Bethesda, United States. In Nat Commun, 2013
STIM1-Orai1 must be in a PM/ER microdomain tethered by E-Syt1, stabilized by septin4 and enriched in PI(4,5)P2 for STIM1-SARAF interaction.
Feedback regulation of receptor-induced Ca2+ signaling mediated by E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions.
Liou et al., Dallas, United States. In Cell Rep, 2013
Elevation of cytosolic Ca(2+) triggered translocation of E-Syt1 to ER-PM junctions to enhance ER-to-PM connection.
PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins.
De Camilli et al., New Haven, United States. In Cell, 2013
Here, we show that the three extended synaptotagmins (E-Syts) are ER proteins that participate in such tethering function via C2 domain-dependent interactions with the PM that require PI(4,5)P2 in the case of E-Syt2 and E-Syt3 and also elevation of cytosolic Ca(2+) in the case of E-Syt1.
The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation.
Charest et al., Boston, United States. In Cancer Res, 2012
E-Syt1 is a mediator of cancer cell invasion.
Establishment and characterization of two human breast carcinoma cell lines by spontaneous immortalization: Discordance between Estrogen, Progesterone and HER2/neu receptors of breast carcinoma tissues with derived cell lines.
Rosli et al., Kuala Selangor, Malaysia. In Cancer Cell Int, 2011
METHODS: Two continuous human breast cell lines, designated MBC1 and MBC2, were successfully established and characterized from invasive ductal breast carcinoma tissues of Malaysian patients.
Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses.
Ueda et al., Fukui, Japan. In Int J Oncol, 2011
The DNA microarray analysis revealed eight genes (C19orf2, HSPA8, LGALS1, POU4F3, PSAP, AKT1, MBC2 and CACNA2D3) that were altered in all five ara-C-resistant lines compared to parental cells.
Detergent fractionation with subsequent subtractive suppression hybridization as a tool for identifying genes coding for plasma membrane proteins.
Eichmüller et al., Heidelberg, Germany. In Exp Dermatol, 2009
We identified some 21 overexpressed genes, among them are GPR137B, FAM62A, NOMO1, HSP90, SLIT1, IBP2, CLIF, IRAK and ARC. mRNA expression was tested for selected genes in CTCL cell lines, skin specimens and peripheral blood samples from CTCL patients and healthy donors.
The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes.
Sandoval et al., Madrid, Spain. In Proc Natl Acad Sci U S A, 2009
Insulin-activated Cdk5 phosphorylates E-Syt1, which associates with GLUT4
Structural characterization of soluble E-Syt2.
Gessner et al., Erlangen, Germany. In Febs Lett, 2008
E-Syt1 to 3 each contain at least one transmembrane domain and three or five C2 domains.
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.
Südhof et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2007
E-Syts contain an N-terminal transmembrane region, a central juxtamembranous domain that is conserved from yeast to human, and five (E-Syt1) or three (E-Syt2 and E-Syt3) C-terminal C(2) domains.
Biodegradable thermo-sensitive nanoparticles from poly(L-lactic acid)/poly(ethylene glycol) alternating multi-block copolymer for potential anti-cancer drug carrier.
Bae et al., Puch'ŏn, South Korea. In Eur J Pharm Sci, 2006
Three different multi-block copolymers were synthesized by varying PLLA molecular weight (800 (MBC1), 1600 (MBC2), and 2800 (MBC3)).
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