gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Matrilin 2

matrilin-2, MATN2
This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibrillin-1, CAN, matrilin-3, fibronectin, entactin
Papers on matrilin-2
Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.
Ahnfelt-Rønne et al., Denmark. In Mol Endocrinol, Jan 2016
Confirming the validity of our approach, we also identified proteins encoded by genes known to be associated with pregnancy-induced islet expansion, such as CHGB, IGFBP5, MATN2, EHHADH, IVD, and BMP1.
The extracellular matrix protein matrilin-2 induces post-burn inflammatory responses as an endogenous danger signal.
Zhang et al., Beijing, China. In Inflamm Res, Oct 2015
OBJECTIVE AND DESIGN: This prospective experimental study aims to investigate whether matrilin-2 is released from burn injury and induces post-burn inflammatory responses as an endogenous danger signal.
Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family.
Hecht et al., Houston, United States. In Mol Genet Genomic Med, Sep 2015
This region contained four genes, Frizzled-6 (FZD6), Matrilin-2 (MATN2), Odd-skipped related 2 (OSR2) and Solute Carrier Family 25, Member 32 (SLC25A32).
DNA Methylation Analysis of Human Trabecular Meshwork Cells During Dexamethasone Stimulation.
Ebihara et al., In Invest Ophthalmol Vis Sci, Jun 2015
RESULTS: After DEX stimulation, we found demethylated cytosine-phosphate-guanine (CpG) sites within the FKBP5, ZBTB16, and SCNN1A gene promoter regions with increases of corresponding gene expression for all three TM batches, and methylated CpG sites within the ARSI, HIC1, GREM2, and MATN2 gene promoter regions with decreases of corresponding of gene expression for all three batches.
Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues.
Kiss et al., Münster, Germany. In Neural Regen Res, Jun 2015
Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2 (Matn2) in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis.
Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution.
Christen et al., Frankfurt am Main, Germany. In Liver Int, Apr 2015
Matrilin-2 is the largest family member and the only matrilin expressed in the naive liver.
Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation.
Gresle et al., In J Clin Invest, 2014
Here, we used the EAE model and determined that the extracellular matrix protein matrilin-2 (MATN2) is an endogenous neuronal molecule that is regulated in association with inflammatory axonal injury.
Microarray-based detection and expression analysis of extracellular matrix proteins in drug‑resistant ovarian cancer cell lines.
Zabel et al., Poznań, Poland. In Oncol Rep, 2014
These genes were: ITGB1BP3, COL3A1, COL5A2, COL15A1, TGFBI, DCN, LUM, MATN2, POSTN and EGFL6.
Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration.
Kiss et al., Szeged, Hungary. In J Cell Sci, 2014
Here, we identify a role for the matrilin-2 (Matn2) extracellular matrix protein in controlling the early stages of myogenic differentiation.
Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5.
Chen et al., Providence, United States. In Molecules, 2013
Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins.
The corneal epithelial basement membrane: structure, function, and disease.
Wilson et al., Cleveland, United States. In Invest Ophthalmol Vis Sci, 2013
Basement membranes are composed of a diverse assemblage of extracellular molecules, some of which are likely specific to the tissue where they function; but in general they are composed of four primary components--collagens, laminins, heparan sulfate proteoglycans, and nidogens--in addition to other components such as thrombospondin-1, matrilin-2, and matrilin-4 and even fibronectin in some BM.
A meta-analysis of microarray-based gene expression studies of olfactory bulb-derived olfactory ensheathing cells.
Verhaagen et al., Amsterdam, Netherlands. In Exp Neurol, 2011
We also identified 7 genes (ENTPD2, MATN2, CTSC, PTHLH, GLRX1, COL27A1 and ID2) with uniformly higher or lower expression in early-passage-OB-OEC in all five microarray comparisons.
[Vitamin K function mediated by activation of steroid and xenobiotic receptor].
Inoue et al., Tokyo, Japan. In Clin Calcium, 2009
In osteoblastic cells, several SXR responsive genes have been identified, including tsukushi, matrilin-2, CD14, and Msx2.
The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration.
Riethmacher et al., Hamburg, Germany. In J Cell Sci, 2009
matrilin 2 is a permissive substrate for axonal growth and cell migration, and that it is required for successful nerve regeneration.
DeltaNp63/BMP-7-dependent expression of matrilin-2 is involved in keratinocyte migration in response to wounding.
Nakagawara et al., Chiba, Japan. In Biochem Biophys Res Commun, 2008
DeltaNp63/BMP-7 signaling pathway modulates wound healing process through the regulation of matrilin-2.
Expression of matrilin-2 in liver cirrhosis and hepatocellular carcinoma.
Kiss et al., Budapest, Hungary. In Pathol Oncol Res, 2008
data indicate matrilin-2 is a novel basement membrane component in the liver, synthesized during sinusoidal "capillarization" in cirrhosis & in hepatocellular carcinoma
Steroid and xenobiotic receptor mediates a novel vitamin K2 signaling pathway in osteoblastic cells.
Inoue et al., Saitama, Japan. In J Bone Miner Metab, 2007
Among them, a small leucine-rich repeat proteoglycan, tsukushi, has been shown to contribute to collagen accumulation, and the protein may interact with another vitamin K2-inducible SXR target, matrilin-2, a member of the matrilin family that functions as collagen adaptors.
Expression of matrilin-2 in oval cells during rat liver regeneration.
Nagy et al., Budapest, Hungary. In Matrix Biol, 2007
Hepatic oval cells produce matrilin-2, an extracellular matrix protein, during liver regeneration.
Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma.
Gutmann et al., Saint Louis, United States. In Neurology, 2006
These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive pilocytic astrocytoma.
The matrilins: a novel family of oligomeric extracellular matrix proteins.
Paulsson et al., Szeged, Hungary. In Matrix Biol, 1999
Matrilin-3 has a similar tissue distribution, while matrilin-2 and -4 occur in a wide variety of extracellular matrices.
share on facebooktweetadd +1mail to friends