gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Membrane-associated ring finger

Marchi, March-1
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010] (from NCBI)
Top mentioned proteins: Ubiquitin, MHC, CAN, IL-10, HAD
Papers on Marchi
Ubiquitylation of CD98 limits cell proliferation and clonal expansion.
Ginsberg et al., San Diego, United States. In J Cell Sci, Jan 2016
CD98 is transcriptionally regulated and ectopic expression of the membrane-associated RING-CH (MARCH) E3 ubiquitin ligases MARCH1 or MARCH8 leads to ubiquitylation and lysosomal degradation of CD98.
Roche et al., Machida, Japan. In J Biol Chem, Dec 2015
We now report that IL-10 stimulates expression of the E3 ubiquitin ligase March-I in activated macrophages, thereby down-regulating MHC-II, CD86, and antigen presentation to CD4 T cells.
Effect of maternal and treatment-related factors on the prevalence of birth defects after PESA-ICSI and TESE-ICSI: a retrospective cohort study.
Braat et al., Nijmegen, Netherlands. In Acta Obstet Gynecol Scand, Nov 2015
MATERIAL AND METHODS: 643 newborns born after PESA-ICSI (n = 406) and TESE-ICSI (n = 237) in Radboud University Medical Center, after a gestational age of 12 weeks, 1 January 2002-1 January 2011 and 1 March-1 November 2014, respectively, were included in this study.
Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis.
Aronica et al., Amsterdam, Netherlands. In Epilepsy Behav, Aug 2015
Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7].
Molecular mechanism and cellular function of MHCII ubiquitination.
Shin et al., San Francisco, United States. In Immunol Rev, Jul 2015
The ubiquitination is mediated by the membrane-associated RING-CH1 (MARCH1) ubiquitin ligase although it can be also mediated by the homologous ligase MARCH8 in model cell lines.
Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm.
Tromp et al., United States. In Int J Mol Sci, 2014
Quantitative PCR assays confirmed a sub-set of the transcription factor binding sites including those in MTMR11, DUSP10, ITGAM, MARCH1, HDAC8, MMP14, MAGI1, THBD and SPOCK1.
Matrix effect and optimization of LC-MSn determination of trachylobane-360 in mice blood.
Sobral et al., João Pessoa, Brazil. In J Pharm Biomed Anal, 2014
According to Marchi et al. (2010), the matrix effect does not necessarily need to be reduced or eliminated, but it does need to be identified and quantified.
tTregs, pTregs, and iTregs: similarities and differences.
Thornton et al., Bethesda, United States. In Immunol Rev, 2014
Interleukin-10 (IL-10) plays an important role in the suppressive function of antigen-specific iTregs by controlling the expression of MARCH1 and CD83 on the DC.
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Jagannath et al., Houston, United States. In Cell Immunol, 2014
TLR-activation led to a down-regulation of MARCH1 ubiquitin ligase which prevents the degradation of MHC-II and decreased IL-10 also contributed to an increase in MHC-II.
Tollip-induced down-regulation of MARCH1.
Thibodeau et al., Montréal, Canada. In Journal 2093-4947, 2012
Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling.
Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study.
Valsecchi et al., Monza, Italy. In Lancet Oncol, 2012
FUNDING: Projet Hospitalier de Recherche Clinique-Cancer (France), Fondazione Tettamanti-De Marchi and Associazione Italiana per la Ricerca sul Cancro (Italy), Novartis Germany, Cancer Research UK, Leukaemia Lymphoma Research, and Central Manchester University Hospitals Foundation Trust.
MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression.
Thibodeau et al., Montréal, Canada. In Cytokine, 2012
IL-10 can have opposite effects on MARCH1 regulation in different cell types.
Autoregulation of MARCH1 expression by dimerization and autoubiquitination.
Thibodeau et al., Montréal, Canada. In J Immunol, 2012
MARCH1 is capable of autoubiquitination, thus regulating its own expression.
Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
Lybarger et al., Tucson, United States. In J Biol Chem, 2011
Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.
Donaldson et al., Bethesda, United States. In Mol Biol Cell, 2011
expression of MARCH1 or MARCH8 causes a drastic change CD98 trafficking after endocytosis
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
Goodnow et al., Canberra, Australia. In J Exp Med, 2011
found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1
Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.
Villadangos et al., Melbourne, Australia. In Nat Immunol, 2008
Here we showed that unlike cDCs, pDCs continued to synthesize major histocompatibility complex (MHC) class II molecules and the MHC class II ubiquitin ligase MARCH1 long after activation.
Spinal cord degeneration in divers.
Hughes et al., Cambridge, United Kingdom. In Lancet, 1988
Marchi-positive degeneration was found in the cords of 3 professional divers, variously affecting the posterior, lateral, and to a lesser extent the anterior columns.
Pruritus in Renal Disease
Mettang, Boca Raton, United States. In Unknown Journal, 0001
Several times in the past a new treatment option has been reported to be effective, but very soon thereafter conflicting results appear (De Marchi et al. 1992; Balaskas and Uldall 1992; Peer et al. 1996; Pauli-Magnus et al. 2000b).
Autoantibodies in CNS Trauma and Neuropsychiatric Disorders: A New Generation of Biomarkers
Moshourab et al., Boca Raton, United States. In Unknown Journal, 0001
A number of neurological disorders are associated with blood–brain barrier (BBB) disruption or increased permeability observed in Alzheimer disease (AD), stroke, TBI, and schizophrenia (Fazio et al., 2004; Marchi et al., 2003, 2004; Neuwelt et al., 2011).
share on facebooktweetadd +1mail to friends