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Mal, T-cell differentiation protein 2

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Mal, CAN, ACID, Actin, OUT
Papers on MAL2
Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington's Disease.
Björkqvist et al., Lund, Sweden. In J Huntingtons Dis, Jan 2016
Using RT-qPCR, we found that MAL2, AGTR2, COBL and the transcription factor CREB1 were significantly upregulated, with CREB1 and AGT also being significantly upregulated in a separate cohort.
Genome-wide association analysis reveals genetic loci and candidate genes for meat quality traits in Chinese Laiwu pigs.
Huang et al., Nanchang, China. In Mamm Genome, Apr 2015
In addition, this study revealed at least five novel QTLs and several candidate genes including 4-linked MYH genes (MYH1, MYH2, MYH3, and MYH13), MAL2, LPAR1, and PRKAG3 at four significant loci.
Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes.
Aravindan et al., Oklahoma City, United States. In Bmc Cancer, 2014
Array CGH analysis of individual clones of MSDACs revealed genetic alterations in chromosomes 1, 7, 8, and 22, corresponding to a gain in the copy numbers of LOC100288142, CD1C, CFHR3, FOXP2, MDFIC, RALYL, CSMD3, SAMD12-AS1, and MAL2, and a loss in ADAM5, LOC400927, APOBEC3B, RPL3, MGAT3, SLC25A17, EP300, L3MBTL2, SERHL, POLDIP3, A4GALT, and TTLL1.
Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target.
Brodsky et al., In Bioorg Med Chem, 2014
Previous screening of pyrimidinone–peptoid hybrid compounds identified MAL2-11B and a MAL2-11B tetrazole derivative as inhibitors of viral replication and T Ag ATPase activity (IC50 of ~20-50 μM.
Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.
Tuma et al., Madrid, Spain. In Biochem J, 2014
MAL2 (myelin and lymphocyte protein 2) is thought to regulate at least two steps in the hepatic apical transcytotic pathway.
Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach.
Goldenring et al., Nashville, United States. In Am J Physiol Gastrointest Liver Physiol, 2014
Gene expression profiling of ImChief and ImSPEM revealed myelin and lymphocyte protein 2 (MAL2) as a novel marker of SPEM lineages.
Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening.
Byrne et al., Westmead, Australia. In Mol Biol Rep, 2014
A large, low-stringency yeast two-hybrid screen using full-length TPD52 bait identified known partners (TPD52, TPD52L1, TPD52L2, MAL2) and four other preys that reproducibly bound TPD52 and TPD52L1 baits (PLP2, RAB5C, GOLGA5, YIF1A).
MAL2 expression predicts distant metastasis and short survival in pancreatic cancer.
Tanaka et al., Fukuoka, Japan. In Surgery, 2013
Mal, T-cell differentiation protein 2 (MAL2) has been identified as a molecule predictive of metastases; the clinical relevance of MAL2 in pancreatic cancer is unknown.
177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model.
Garrison et al., Omaha, United States. In Nucl Med Biol, 2013
METHODS: In this study three MALs (MAL0, MAL1 and MAL2) were investigated.
MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
Millán et al., Madrid, Spain. In Mol Biol Cell, 2013
In epithelial cells, the MAL family members MAL, MAL2, and myeloid-associated differentiation marker (MYADM) regulate the function and dynamics of ordered membrane domains.
DNA methylation in the malignant transformation of meningiomas.
Wang et al., Los Angeles, United States. In Plos One, 2012
One exception is the MAL2 gene that is highly expressed in benign group and silenced in malignant group, representing de novo gene silencing induced by DNA methylation.
MAL, but not MAL2, expression promotes the formation of cholesterol-dependent membrane domains that recruit apical proteins.
Tuma et al., Washington, D.C., United States. In Biochem J, 2011
MAL (myelin and lymphocyte protein) and its highly conserved family member, MAL2, have emerged as possible regulators of this process in the direct and indirect apical trafficking pathways respectively.
Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.
López-Guerrero et al., Madrid, Spain. In Plos One, 2010
Results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.
MAL2 selectively regulates polymeric IgA receptor delivery from the Golgi to the plasma membrane in WIF-B cells.
Tuma et al., Washington, D.C., United States. In Traffic, 2010
Data show that in addition to its role in transcytosis, MAL2 also regulates polymeric IgA receptor delivery from the Golgi to the plasma membrane.
Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein.
Jahn et al., Göttingen, Germany. In J Neurosci, 2010
MAL2 is a novel synaptic vesicle protein that is preferentially associated with vesicular glutamate (VGLUT-1)-containing nerve terminals.
MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.
O'Brien et al., Westmead, Australia. In Bmc Cancer, 2009
MAL2 overexpression was highest in serous carcinomas relative to other histological subtypes of ovarian cancer.
Characterization of the MAL2-positive compartment in oligodendrocytes.
López-Guerrero et al., Madrid, Spain. In Exp Cell Res, 2009
after differentiation, murine oligodendrocyte precursor and human oligodendroglioma derived cell lines up-regulate the expression of MAL2 and accumulate it in an intracellular compartment, exhibiting a peri-centrosomal localization.
Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue.
Alonso et al., Madrid, Spain. In Histol Histopathol, 2004
MAL and MAL2 have been demonstrated to be essential components of the machinery for the direct and indirect routes, respectively.
Control of maltase synthesis in yeast.
Needleman, Detroit, United States. In Mol Microbiol, 1991
Maltose fermentation in Saccharomyces species requires the presence of at least one of five unlinked MAL loci: MAL1, MAL2, MAL3, MAL4 and MAL6.
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