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Microfibrillar-associated protein 2

MAGP, MAGP-1, Microfibril-associated glycoprotein-1, MFAP2, Microfibril-associated glycoprotein
Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
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Top mentioned proteins: CD45, fibrillin-1, elastin, MAGP-2, ACID
Papers on MAGP
The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche.
Gibson et al., Saint Louis, United States. In Matrix Biol, Sep 2015
The microfibril-associated glycoproteins MAGP-1 and MAGP-2 are extracellular matrix proteins that interact with fibrillin to influence microfibril function.
Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.
Apte et al., Cleveland, United States. In Dis Model Mech, May 2015
An increase in microfibrils in the bronchial wall was associated with increased FBN2 and microfibril-associated glycoprotein-1 (MAGP1) staining, whereas LTBP1 staining was increased in bronchial epithelium.
Borderline personality disorder and childhood maltreatment: a genome-wide methylation analysis.
Perroud et al., Genève, Switzerland. In Genes Brain Behav, Feb 2015
Several CpGs within or near the following genes (IL17RA, miR124-3, KCNQ2, EFNB1, OCA2, MFAP2, RPH3AL, WDR60, CST9L, EP400, A2ML1, NT5DC2, FAM163A and SPSB2) were found to be differently methylated, either in BPD compared with MDD or in relation to the severity of childhood maltreatment.
MAGP1, the extracellular matrix, and metabolism.
Craft, Saint Louis, United States. In Adipocyte, 2015
We recently published a series of studies that identified a novel mechanism whereby an extracellular matrix molecule, MAGP1 (microfibril associated glycoprotein 1), can regulate energy metabolism in adipose tissue.
MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections.
Boileau et al., Paris, France. In Am J Hum Genet, 2015
Through whole-exome sequencing of affected members in a large TAAD-affected family, we identified the c.472C>T (p.Arg158(∗)) nonsense mutation in MFAP5 encoding the extracellular matrix component MAGP-2.
Human eye development is characterized by coordinated expression of fibrillin isoforms.
Apte et al., Cleveland, United States. In Invest Ophthalmol Vis Sci, 2014
However, the expression pattern of the three human fibrillins and an integral microfibrillar component, MAGP1, during human eye development is not known.
The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β.
Mecham et al., Saint Louis, United States. In Diabetes, 2014
Microfibril-associated glycoprotein 1 (MAGP1) is a component of extracellular matrix microfibrils.
Gene set enrichment analysis of the NF-κB/Snail/YY1/RKIP circuitry in multiple myeloma.
Spandidos et al., Irákleion, Greece. In Tumour Biol, 2014
Among many, we highlighted on FNDC3B, TPD52, BBX, MBNL1 and MFAP2.
Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.
Ishikawa et al., Fukuoka, Japan. In Acta Histochem Cytochem, 2014
Microfibril-associated glycoprotein-1 (MAGP-1) is the only microfibril-associated molecule identified in the human ciliary zonule.
Domain 36 of tropoelastin in elastic fiber formation.
Wachi et al., In Biol Pharm Bull, 2013
Moreover, the binding affinity of these mutants to fibrillin-1 and microfibril-associated glycoprotein (MAGP) was significantly decreased.
Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.
Mecham et al., In J Biol Chem, 2013
Microfibril-associated glycoprotein (MAGP) 1 and 2 are evolutionarily related but structurally divergent proteins that are components of microfibrils of the extracellular matrix.
Systemic sclerosis sera affect fibrillin-1 deposition by dermal blood microvascular endothelial cells: therapeutic implications of cyclophosphamide.
Weber et al., In Arthritis Res Ther, 2012
In the present study, we evaluated the effects of SSc sera on the deposition of fibrillin-1 and microfibril-associated glycoprotein 1 (MAGP-1) and the expression of focal adhesion molecules by dermal B-MVECs and Ly-MVECs.
Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study.
Santhanam et al., New York City, United States. In Clin Cosmet Investig Dermatol, 2012
Microfibril-associated glycoprotein-1 (MAGP-1) is an extracellular matrix protein critical for elastic fiber assembly.
NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment.
Menevse et al., Ankara, Turkey. In Gene, 2012
Decreased MFAP2 gene expression in the endometrium of patients with implantation failure after in vitro ertilization treatment.
Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.
Mecham et al., Saint Louis, United States. In J Cell Biochem, 2012
These studies provide support for increased RANKL expression associated with MAGP1 deficiency and provide a link to altered TGF-beta signaling as a possible causative signaling pathway regulating RANKL expression in MAGP1-deficient osteoblasts.
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Tobin et al., Leicester, United Kingdom. In Nat Genet, 2011
We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2.
Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc.
Melrose et al., Cardiff, United Kingdom. In Spine (phila Pa 1976), 2011
Demonstrate specific immunolocalization of fibrillin-1, MAGP-1, and LTBP-1 with elastin in the outer annulus fibrosus of the fetal human intravertebral disc.
Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling.
Mecham et al., Saint Louis, United States. In J Biol Chem, 2010
MAGP1 is a regulator of bone remodeling, and its absence results in osteopenia associated with an increase in osteoclast number
Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.
Mecham et al., Saint Louis, United States. In J Biol Chem, 2008
microfibril-associated glycoprotein-1 has a role in complex phenotypes in multiple organ systems
[Regulation of elastin synthesis].
Osborne-Pellegrin et al., Paris, France. In J Soc Biol, 2000
Elastin is the main protein of elastic fibers and confers the property of elastic recoil to the tissues such as arteries, lung, elastic cartilage,... Elastin synthesis goes through several steps: gene transcription, alternative splicing of pre-mRNA, mRNA translation, hydroxylation of some proline residues of the newly synthesized protein-tropoelastin-, association of with a 67 kDa chaperone protein, secretion of tropoelastin molecules in the extracellular space, and their deposition on the microfibrillar scaffold which contains fibrillin 1, fibrillin 2, MAGP 1 and MAGP 2,....
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