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Melanoma antigen family D, 2

MAGE-D, MAGE-D2, BcgI, breast cancer associated gene 1
This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Iris, POLYMERASE, OUT
Papers on MAGE-D
The Expression of Melanoma-Associated Antigen D2 Both in Surgically Resected and Serum Samples Serves as Clinically Relevant Biomarker of Gastric Cancer Progression.
Kodera et al., Nagoya, Japan. In Ann Surg Oncol, Feb 2016
METHODS: Expression analysis of MAGE-D2 was conducted in GC cell lines and clinical samples (surgical specimen and serum) in both mRNA and protein level.
Melanoma antigen-D2: A nucleolar protein undergoing delocalization during cell cycle and after cellular stress.
Habraken et al., Li├Ęge, Belgium. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: Melanoma antigen D2 (MAGE-D2) is recognized as a cancer diagnostic marker; however, it has poorly characterized functions.
Noninvasive pulse transit time measurement for arterial stiffness monitoring in microgravity.
Kovacs et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
PTT was measured from the BCG I-wave to the intersecting tangents of the first trough and maximum first derivative of the PPG waveforms of each subject.
Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression.
Cryns et al., Madison, United States. In Clin Cancer Res, Jul 2015
The melanoma-associated antigen MAGED2 was silenced to delineate its functional role in sensitizing TNBC cells to methionine stress.
New shuttle vector-based expression system to generate polyhistidine-tagged fusion proteins in Staphylococcus aureus and Escherichia coli.
Perreten et al., Bern, Switzerland. In Appl Environ Microbiol, Jun 2015
BcgI-induced DNA excision followed by religation converts the TGA stop codon of the MCS into a TGC codon and links the rgs-his6 codons to the 3' end of the target gene.
Aberrant expression of melanoma-associated antigen-D2 serves as a prognostic indicator of hepatocellular carcinoma outcome following curative hepatectomy.
Kodera et al., Nagoya, Japan. In Oncol Lett, Mar 2015
In the present study, the expression of the melanoma-associated antigen-D2 (MAGE-D2) gene was investigated to determine whether it affects the malignant phenotype of HCC and thus, may serve as a marker of prognosis.
TstI, a Type II restriction-modification protein with DNA recognition, cleavage and methylation functions in a single polypeptide.
Halford et al., Bristol, United Kingdom. In Nucleic Acids Res, 2014
Several Type IIB proteins, including the archetype BcgI, are assemblies of two polypeptides: one with endonuclease and methyltransferase roles, another for DNA recognition.
Organization of the BcgI restriction-modification protein for the cleavage of eight phosphodiester bonds in DNA.
Sobott et al., Bristol, United Kingdom. In Nucleic Acids Res, 2013
Type IIB restriction-modification systems, such as BcgI, feature a single protein with both endonuclease and methyltransferase activities.
Organization of the BcgI restriction-modification protein for the transfer of one methyl group to DNA.
Halford et al., Bristol, United Kingdom. In Nucleic Acids Res, 2013
The Type IIB restriction-modification protein BcgI contains A and B subunits in a 2:1 ratio: A has the active sites for both endonuclease and methyltransferase functions while B recognizes the DNA.
Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethnic population of Saudi Arabia, an emerging high-risk area.
Alshatwi et al., Riyadh, Saudi Arabia. In Asian Pac J Cancer Prev, 2012
We aimed at determining whether any association exists between single nucleotide polymorphisms in breast cancer associated gene 1 (BRCA1) and breast cancer associated gene 2 (BRCA2) and the risk of breast cancer.
IGF signaling pathway as a selective target of familial breast cancer therapy.
Deng et al., Bethesda, United States. In Curr Mol Med, 2008
In most cases, they can be attributed to mutations in the breast cancer associated gene 1 and 2 (BRCA1 and BRCA2).
Cell biology of cancer: BRCA1 and sister chromatid pairing reactions?
Skibbens, Bethlehem, United States. In Cell Cycle, 2008
A significant portion of familial breast/ovarian cancer patients harbors a mutation in Breast Cancer Associated gene 1 (BRCA1).
MAGED2: a novel p53-dissociator.
McLeod et al., Columbia, United States. In Int J Oncol, 2007
MAGED2, a novel protein, is a p53-dissociator.
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.
Deng, Bethesda, United States. In Nucleic Acids Res, 2005
Germline mutations of the breast cancer associated gene 1 (BRCA1) predispose women to breast and ovarian cancers.
RumMAGE-D the members: structure and function of a new adaptor family of MAGE-D proteins.
Watanabe et al., Sapporo, Japan. In J Recept Signal Transduct Res, 2004
Because some MAGE-D subfamily proteins share significant homology within the MHD, these recent discoveries on MAGE-D1 may give insight into the function of other MAGE-D proteins.
Identification of a novel MAGE D2 antisense RNA transcript in human tissues.
Wu et al., Davis, United States. In Biochem Biophys Res Commun, 2004
Results identified a cDNA clone, corresponding to MAGE D2 mRNA, from primary human bronchial epithelial cells which exhibits increased expression in vitro after treatment with all-trans retinoic acid.
Comparative expression analysis of the MAGED genes during embryogenesis and brain development.
De Backer et al., Namur, Belgium. In Dev Dyn, 2004
Maged2 is mainly expressed in tissues of mesodermal origin
Cancer/testis antigens: structural and immunobiological properties.
Zeuthen et al., In Cancer Invest, 2001
The MAGE superfamily includes five families: MAGE-A, MAGE-B, MAGE-C, MAGE-D, and necdin.
Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues.
Wieacker et al., Magdeburg, Germany. In Cytogenet Cell Genet, 2000
Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues
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