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Melanoma antigen family B, 3

This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, MAGE-B1, V1a, MAGEB4, MAGE-B2
Papers on Mage-b3
Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer.
Lin et al., Kao-hsiung, Taiwan. In J Surg Oncol, 2010
MAGE-B3 gene expression is statistically correlated with tumor size, lymph node, and UICC stage.
Hyperthermia enhances CTL cross-priming.
Banchereau et al., Dallas, United States. In J Immunol, 2006
Second, hyperthermia resulted in the increased transcription of several tumor Ag-associated Ags, including MAGE-B3, -B4, -A8, and -A10.
Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines.
Gravekamp et al., San Antonio, United States. In Breast Cancer Res Treat, 2002
RT-PCR products obtained from the mammary tumors (using primers that amplify the complete protein-encoding region of Mage-b1/2/3) were cloned and sequenced, and appeared to be most homologous with Mage-b3.
Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.
Boon et al., Brussels, Belgium. In Genomics, 1998
It contains four MAGE-related genes, which we propose to name MAGE-B1, B2, B3, and B4 (HGMW-approved symbols MAGEB1, MAGEB2, MAGEB3, and MAGEB4).
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