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Melanoma antigen family A, 6

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAGE-1, MAGE-3, POLYMERASE, MAGE-2, CAN
Papers on MAGE-6
Circulating Type-1 Anti-Tumor CD4(+) T Cells are Preferentially Pro-Apoptotic in Cancer Patients.
Storkus et al., Pittsburgh, United States. In Front Oncol, 2013
We observed that Flu-specific CD4(+) T cells ranged from 0.17 to 3.89%, while up to approximately 1% of CD4(+) T cells reacted against individual TAA epitopes derived from the EphA2 or MAGE-6 proteins.
MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.
Jeon et al., Taegu, South Korea. In Oncol Rep, 2012
Report MAGEA1-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.
Expression of melanoma-associated antigens in oral squamous cell carcinoma.
Nkenke et al., Erlangen, Germany. In J Oral Pathol Med, 2008
Multiple simultaneous detection of MAGE-A [subtypes] more specific and sensitive than detection of single MAGE-A antigen for the diagnostic and prognostic evaluation of oral squamous cell carcinoma
Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regression.
Robbins et al., Bethesda, United States. In J Immunother, 2005
The most highly persistent clonotype, which expressed the BV1 TR gene product, recognized the MAGE-6 cancer/testis antigen in the context of HLA-A23.
Investigation of the expression of melanoma antigen-encoding genes (MAGE-A1 to -A6) in oral squamous cell carcinomas to determine potential targets for gene-based cancer immunotherapy.
Wiltfang et al., Erlangen, Germany. In Int J Oncol, 2005
The expression pattern of subtypes was heterogeneous: 62% of the tumor patients were positive for MAGE-3, 57% for MAGE-4, 48% for MAGE-6, 43% for MAGE-1, 38% for MAGE-2 and 24% for MAGE-5.
Effect of renal cell carcinomas on the development of type 1 T-cell responses.
Finke et al., Cleveland, United States. In Clin Cancer Res, 2004
PURPOSE: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly skewed toward TH2-type cytokine responses [interleukin (IL) 5].
A new tumor-specific antigenic peptide encoded by MAGE-6 is presented to cytolytic T lymphocytes by HLA-Cw16.
van der Bruggen et al., Brussels, Belgium. In Cancer Immun, 2004
MAGE-6 is expressed in more than 70% of metastatic melanomas and more than 50% of carcinomas of the lung, esophagus, bladder, and head and neck.
Expression of cancer/testis (CT) antigens in lung cancer.
Mitsudomi et al., Nagoya, Japan. In Lung Cancer, 2003
For this purpose, vaccination with combinations of MAGE-3 with MAGE-6, SSX-4, MAGE-1 or BAGE may be effective for a quarter of Japanese lung cancer patients.
Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.
Seiden et al., Boston, United States. In Clin Cancer Res, 2003
Northern analysis demonstrates overexpression of MAGE2 but not Centrin 2. Extension of this analysis to other neighboring and non-neighboring representative cancer testis antigens reveals overexpression of MAGE3, MAGE6, MAGE11, and MAGE12, as well as GAGE-2, GAGE-4, GAGE-5, GAGE-6, and GAGE-7 (clustered on Xp11) in SKOV-3(TR), as compared with SKOV-3.
MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma.
Storkus et al., Pittsburgh, United States. In Clin Cancer Res, 2003
MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma.
Storkus et al., Pittsburgh, United States. In J Exp Med, 2002
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma.
MAGE, BAGE and GAGE gene expression in human rhabdomyosarcomas.
Zanovello et al., Padova, Italy. In Int J Cancer, 2001
Using RT-PCR, we analyzed MAGE-1, MAGE-2, MAGE-3, MAGE-4, MAGE-6, BAGE, GAGE-1,-2 or -8 and GAGE-3,-4,-5,-6 or -7b gene expression in 31 samples of pediatric rhabdomyosarcoma, the most frequent form of malignant soft tissue tumor in children.
Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.
Old et al., New York City, United States. In Cancer Immun, 2001
MAGE-3, MAGE-6, NY-ESO-1, Her2neu and p53, as well as newly-defined breast cancer antigens, e.g.
MAGE-12 and MAGE-6 are frequently expressed in malignant melanoma.
Cebon et al., Australia. In Melanoma Res, 2000
Although MAGE-6 and MAGE-12 were originally identified in malignant melanoma there are no studies reporting the frequency of expression of these antigens in this malignancy.
MAGE-1 and related MAGE gene expression may be associated with hepatocellular carcinoma.
Tang et al., Shanghai, China. In J Cancer Res Clin Oncol, 1999
The three clones were confirmed to be a full-length MAGE-1 gene, a 750-bp fragment of the MAGE-3 gene and a fragment highly homologous to MAGE-6 and MAGE-12 but not identical to any known MAGE genes.
Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family.
Traversari et al., Milano, Italy. In Cancer Res, 1999
Moreover, the CTLs also recognized a MAGE-6-positive melanoma line transfected with the B*3701 molecule.
High frequency of the expression of the MAGE gene family in human esophageal carcinoma.
Akiyoshi et al., Beppu, Japan. In Int J Oncol, 1997
The expression rate varied from 13% of MAGE-6 and 8 to 79% of MAGE-4 in the esophageal carcinoma cell lines, and from 6% of MAGE-6 to 62% of MAGE-4 in clinical tumor samples.
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