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Melanoma antigen family A, 4

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAGE-1, MAGE-3, NY-ESO-1, POLYMERASE, SSX2
Papers on MAGE-4
MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles.
Huang et al., Beijing, China. In Cell Immunol, Sep 2015
By using Molecular-Docking method, 3 MAGEA10 peptides were found binding to the groove position of HLA-A(∗)0210 as same as MAGEA4 peptide co-crystallized with HLA-A(∗)0210, which indicates that they could be promising for HLA-A(∗)0201 presentation in immunotherapy.
Expansion and long-term culture of human spermatogonial stem cells via the activation of SMAD3 and AKT pathways.
He et al., Shanghai, China. In Exp Biol Med (maywood), Aug 2015
These freshly isolated cells expressed a number of markers for SSCs, including GPR125, PLZF, GFRA1, RET, THY1, UCHL1 and MAGEA4, but not the hallmarks for spermatocytes and spermatozoa, e.g.
AZFc deletions do not affect the function of human spermatogonia in vitro.
Repping et al., Winston-Salem, United States. In Mol Hum Reprod, Jul 2015
The only exception was melanoma antigen family A4 (MAGEA4) which showed significantly lower expression in AZFc-deleted samples than controls in short-term culture while in long-term culture it was hardly detected in both AZFc-deleted and control spermatogonia.
Identification of miR-145 targets through an integrated omics analysis.
Pandey et al., Baltimore, United States. In Mol Biosyst, 2015
In our transcriptomic analysis, overexpression of miR-145 was found to suppress the expression of genes that are implicated in development of cancer such as ITGA11 and MAGEA4 in addition to previously described targets such as FSCN1, YES1 and PODXL.
Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes.
Klein et al., Regensburg, Germany. In Cancer Res, 2015
Transcriptomes of all cells were examined for the expression of EPCAM, KRT8, KRT18, KRT19, KRT14, KRT6a, KRT5, KLK3 (PSA), MAGEA2, MAGEA4, PTPRC (CD45), CD33, CD34, CD19, GYPC, SCL4A1 (band 3), and HBA2.
A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults.
Simpson et al., Houston, United States. In Exerc Immunol Rev, 2014
TAA-specific CTLs were expanded using autologous monocyte-derived-dendritic cells pulsed with melanoma-associated antigen 4 (MAGE-A4), with preferentially expressed antigen in melanoma (PRAME), and with Wilms' tumor protein (WT-1).
Establishment and Characterization of Human Germline Stem Cell Line with Unlimited Proliferation Potentials and no Tumor Formation.
He et al., Shanghai, China. In Sci Rep, 2014
RT-PCR, immunocytochemistry, and Western blots revealed that this cell line was positive for a number of human spermatogonial and SSC hallmarks, including VASA, DAZL, MAGEA4, GFRA1, RET, UCHL1, GPR125, PLZF and THY1, suggesting that these cells are human SSCs phenotypically.
Predictive and prognostic effect of CD133 and cancer-testis antigens in stage Ib-IIIA non-small cell lung cancer.
Zhou et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
When combined with MAGEA4, NY-ESO-1or MAGE-A10, patients' OS showed significantly difference among different combination.
Dysregulation of X chromosome inactivation in high grade ovarian serous adenocarcinoma.
Maeng et al., South Korea. In Plos One, 2014
We found four genes (XAGE3, ZNF711, MAGEA4, and ZDHHC15) that were up-regulated by loss of XCI.
Histological and immunohistochemical markers for progression prediction in transurethrally resected high-grade non-muscle invasive bladder cancer.
Shim et al., South Korea. In Int J Clin Exp Pathol, 2014
To define useful prognostic markers for progression, we analyzed clinicopathological features and immunohistochemical expression patterns of E2F1, p27, survivin, p53, EZH2, IMP3, TSC1/hamartin, fatty acid synthase, androgen receptor, 14-3-3σ, MAGEA4, and NY-ESO-1 on 118 cases of high-grade Non-MIBC.
Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.
Looijenga et al., Edinburgh, United Kingdom. In Mod Pathol, 2014
Testicular germ cell cancer develops from premalignant intratubular germ cell neoplasia, unclassified cells that are believed to arise from failure of normal maturation of fetal germ cells from gonocytes (OCT4(+)/MAGEA4(-)) into pre-spermatogonia (OCT4(-)/MAGEA4(+)).
Cancer testis antigen expression in testicular germ cell tumorigenesis.
Moch et al., Zürich, Switzerland. In Mod Pathol, 2014
Immunohistochemistry was used to study MAGEA3, MAGEA4, MAGEC1, GAGE1 and CTAG1B expression in 325 primary testicular germ cell tumors, including 94 mixed germ cell tumors.
Cellular evidence for selfish spermatogonial selection in aged human testes.
Wilkie et al., Oxford, United Kingdom. In Andrology, 2014
In a recent study that aimed to identify these clones directly, we stained serial sections of fixed testes for expression of melanoma antigen family A4 (MAGEA4), a marker of spermatogonia.
Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.
Sato et al., Sapporo, Japan. In Tissue Antigens, 2013
Eighteen genes (MAGEA2, MAGEA3, MAGEA4, MAGEA6, MAGEA12, MAGEB2, GAGE1, GAGE8, SPANXA1, SPANXB1, SPANXC, XAGE2, SPA17, BORIS, PLU-1, SGY-1, TEX15 and CT45A1) showed higher expression levels in SP cells than in MP cells, whereas 10 genes (BAGE1, BAGE2, BAGE4, BAGE5, XAGE1, LIP1, D40, HCA661, TDRD1 and TPTE) showed similar expression levels in SP cells and MP cells.
MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.
Jeon et al., Taegu, South Korea. In Oncol Rep, 2012
Report MAGEA1-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma.
Sakaguchi et al., Ōsaka, Japan. In Blood, 2012
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma.
Identification of a novel CD8+ T cell epitope derived from cancer-testis antigen MAGE-4 in oesophageal carcinoma.
Ye et al., Zhengzhou, China. In Scand J Immunol, 2011
novel HLA-A2-restricted T cell epitope derived from MAGE-4 was identified
Cancer-testis gene expression profiling in esophageal squamous cell carcinoma: identification of specific tumor marker and potential targets for immunotherapy.
Abbaszadegan et al., Tehrān, Iran. In Cancer Biol Ther, 2011
MAGE-A4 is identified as a specific biomarker of esophageal squamous cell carcinoma with a possible oncogenic role contributing to tumor progression.
MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma.
Tomas et al., Zagreb, Croatia. In Eur J Histochem, 2010
Primary tumors with and without lymph node metastases showed no significant differences in MAGE-A 3/4 (P=0.672) and NY-ESO-1 (P=0.444) expression
Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects.
Rajpert-De Meyts, Copenhagen, Denmark. In Hum Reprod Update, 2006
MAGEA4, VASA, TSPY and NY-ESO-1), supported by studies of regulatory elements of the cell cycle (e.g.
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