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V-maf musculoaponeurotic fibrosarcoma oncogene homolog G

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010] (from NCBI)
Top mentioned proteins: MAF, NF-E2, Nrf2, MAFF, CAN
Papers on MafG
Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma.
Green et al., Worcester, United States. In Proc Natl Acad Sci U S A, Feb 2016
In both CRC and melanoma, BRAF(V600E) promotes epigenetic silencing through up-regulation of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G (MAFG), a transcriptional repressor with sequence-specific DNA-binding activity.
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells.
Tang et al., Guangzhou, China. In Hepatology, Jan 2016
Additionally, nuclear NRF2 interacted with transcriptional coactivator small v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog proteins such as MafG and then activated transcription of quinone oxidoreductase-1, heme oxygenase-1, and ferritin heavy chain-1.
Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.
Tang et al., Loma Linda, United States. In Neurobiol Dis, Oct 2015
This study examined the therapeutic effect of dimethyl fumarate (DMF), a fumaric acid ester that activates nuclear factor erythroid-2 related factor 2 (Nrf2) and Nrf2 heterodimerization effector protein musculo-aponeurotic fibrosarcoma-G (MAFG) in a murine ICH model.
Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant-mitochondrial response in mouse beta cells.
Laybutt et al., Sydney, Australia. In Diabetologia, Apr 2015
ID1, ID3 and small MAF proteins (MAFF, MAFG and MAFK) were inhibited using small interfering RNA.
MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
Edwards et al., Los Angeles, United States. In Cell Metab, Mar 2015
We identify MafG as an FXR target gene and show that hepatic MAFG overexpression represses genes of the bile acid synthetic pathway and modifies the biliary bile acid composition.
Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice.
Lu et al., Los Angeles, United States. In Antioxid Redox Signal, Feb 2015
However, Nrf2 heterodimerization with MafG was enhanced by LCA, which prompted us to examine whether LCA treatment in vivo altered proteins that bind to ARE using biotinylated ARE in pull-down assay followed by proteomics.
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype.
Green et al., Worcester, United States. In Mol Cell, 2014
Through an RNAi screen, here we identify the transcriptional repressor MAFG as the pivotal factor required for MLH1 silencing and CIMP in CRCs containing BRAF(V600E).
Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice.
Lu et al., Los Angeles, United States. In Free Radic Biol Med, 2014
The key mechanism was a decrease in sumoylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and MafG, which is required for their heterodimerization and subsequent binding and trans-activation of the antioxidant-response element (ARE) present in the promoter region of these genes that is essential for their expression.
Comprehensive bioinformation analysis of the mRNA profile of fascin knockdown in esophageal squamous cell carcinoma.
Li et al., Guangzhou, China. In Asian Pac J Cancer Prev, 2012
MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes.
The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives.
Blank et al., Montréal, Canada. In Biochim Biophys Acta, 2012
The small MAFs, MAFF, MAFG and MAFK have emerged as crucial regulators of mammalian gene expression.
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2012
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
MAFG is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Molecular determinants for small Maf protein control of platelet production.
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2011
The MafG C terminus is essential for proplatelet formation and platelet gene activation but not for p45 binding to the Maf recognition element (MARE).
Intrinsic and extrinsic effects of mafG deficiency on hematopoietic recovery following bone marrow transplant.
Slayton et al., Gainesville, United States. In Exp Hematol, 2010
mafG expression has intrinsic and extrinsic effects on hematopoietic engraftment following bone marrow transplantation.
Structural basis of alternative DNA recognition by Maf transcription factors.
Tanaka et al., Sendai, Japan. In Mol Cell Biol, 2009
determined the crystal structure of the MafG-DNA complex; each MafG monomer consists of three helices in which the carboxyl-terminal long helix organizes one DNA-contacting element and one coiled-coil dimer formation element.
Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?
Blank, Montréal, Canada. In J Mol Biol, 2008
The small Maf basic leucine zipper (bZIP) proteins MafF, MafG and MafK, while modest in size, have emerged as crucial regulators of mammalian gene expression.
Nrf2 signaling in coordinated activation of antioxidant gene expression.
Jaiswal, Houston, United States. In Free Radic Biol Med, 2004
Additional nuclear factor including small Mafs (MafG and MafK), large Maf (c-Maf), c-Fos, and Fra1, also bind to ARE and negatively regulate ARE-mediated gene expression.
Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins.
Yamamoto et al., Tsukuba, Japan. In Cell, 2001
Megakaryocytes from the latter overexpressing lines exhibited reduced proplatelet formation and MARE-dependent transcription, phenocopying mafG null mutant mice.
The world according to Maf.
Engel et al., Tsukuba, Japan. In Nucleic Acids Res, 1997
The small Maf proteins (MafF, MafG and MafK), as do all family members, include a characteristic basic region linked to a leucine zipper (b-Zip) domain which mediate DNA binding and subunit dimerization respectively.
Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins.
Yamamoto et al., Sendai, Japan. In Nature, 1994
We show here that products of the maf proto-oncogene family, MafF, MafG and MafK (the small Maf proteins) which possess a b-zip DNA-binding domain but lack a canonical transactivation domain, directly control the DNA-binding properties of p45 by heterodimeric association with p45.
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