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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

V-maf musculoaponeurotic fibrosarcoma oncogene family, protein B

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAF, CAN, Insulin, AP-1, Glucagon
Papers using MafB antibodies
Papers on MafB
Alpha-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin.
Gosmain et al., Genève, Switzerland. In Endocrinology, Jan 2016
We identified genes coding for proteins involved in glucagon biosynthesis and secretion, α-cell differentiation and potential stress markers such as the glucagon, Arx, MafB, cMaf, Brain4, Foxa1, Foxa3, HNF4α, TCF7L2, Glut1, Sglt2, Cav2.1, Cav2.2, Nav1.7,
Androgen regulates Mafb expression through its 3'UTR during mouse urethral masculinization.
Yamada et al., Wakayama, Japan. In Endocrinology, Jan 2016
We have previously shown that v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is an androgen-inducible regulator of embryonic urethral masculinization in mice.
Systematic analyses of murine masculinization processes based on genital sex differentiation parameters.
Yamada et al., Wakayama, Japan. In Dev Growth Differ, Dec 2015
We define the sexual differences of external genitalia and perineum by GSDP through analyzing mouse models, androgen inhibitor-induced feminization experiments and Mafb mutant mouse with defective urethral differentiation.
DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium.
Detmar et al., Zürich, Switzerland. In Cell Rep, Dec 2015
We found that MAFB, a TF involved in differentiation of various cell types, is rapidly induced and activated by VEGF-C.
Towards an understanding of kidney diseases associated with WT1 mutations.
Englert et al., Jena, Germany. In Kidney Int, Oct 2015
WT1 controls metanephric mesenchyme (MM) self-renewal and proliferation mainly by regulating FGF and BMP-pSMAD signaling pathways as well as Sall1 and Pax2, encoding key transcription factors; WT1 drives MM differentiation and mesenchyme-epithelial transition by targeting Fgf8 and Wnt4; WT1 defines podocyte identity by activation of other podocyte-specific transcription factors, including Mafb, Lmx1b, FoxC2, and Tcf21.
Transcriptional factors, Mafs and their biological roles.
Tsuchiya et al., Tokyo, Japan. In World J Diabetes, Mar 2015
The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper.
Serum amyloid A inhibits RANKL-induced osteoclast formation.
Bae et al., Suwŏn, South Korea. In Exp Mol Med, 2014
SAA not only markedly blocked the expression of several osteoclast-associated genes (TNF receptor-associated factor 6 and osteoclast-associated receptor) but also strongly induced the expression of negative regulators (MafB and interferon regulatory factor 8).
New players in the toxin field: polymorphic toxin systems in bacteria.
Nassif et al., In Mbio, 2014
We have recently characterized the MafB toxins, a new family of PTS deployed by pathogenic Neisseria spp.
Association of candidate genes with nonsyndromic clefts in Honduran and Colombian populations.
Haddad et al., New York City, United States. In Laryngoscope, 2012
MAFB gene suggest a role for the development of orofacial clefting in hispanic population.
Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.
Zhang et al., Lyon, France. In Oncogene, 2012
The data showed that Men1 inactivation led to MafB reexpression in mouse beta cells in vivo, and provides evidence that deregulated ectopic MafB expression may have a hitherto unknown role in adult beta cell proliferation and Men1-related tumorigenesis.
Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB.
Brown et al., Brisbane, Australia. In Am J Hum Genet, 2012
Identified previously unreported missense mutations clustering within a 51 base pair region of the single exon of MAFB, validated by Sanger sequencing.
High MafB expression following burn augments monocyte commitment and inhibits DC differentiation in hemopoietic progenitors.
Muthu et al., Chicago, United States. In J Leukoc Biol, 2012
High MafB following experimental burn plays an inhibitory role in monocyte-derived dendritic cell differentiation by regulating monocyte-colony factor receptor (M-CSFR) and GATA-1 expression.
The kreisler mutation leads to the loss of intrinsically hypoxia-activated spots in the region of the retrotrapezoid nucleus/parafacial respiratory group.
Bodineau et al., Amiens, France. In Neuroscience, 2011
The homozygous kreisler mutation eliminates most of rhombomere 5 and mis-specifies rhombomere 6, abolishes an early decrease in respiratory frequency within 10 min of hypoxia and an intrinsic hypoxic activation.
Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.
Philippe et al., Genève, Switzerland. In Diabetes Obes Metab, 2011
Pax6, along with cMaf and MafB, binds to the DNA control element G(1) which confers α-cell specificity to the promoter and to G(3) and potently activates glucagon gene transcription.
MafA and MafB activity in pancreatic β cells.
Stein et al., Nashville, United States. In Trends Endocrinol Metab, 2011
Analyses in mouse models have revealed crucial roles for MafA (musculoaponeurotic fibrosarcoma oncogene family A) and MafB in islet β cells, with MafB being required during development and MafA in adults.
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Seed et al., Boston, United States. In Nat Immunol, 2010
MafB acts as a metastable switch to control expression of IFN-beta.
MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.
Sieweke et al., Marseille, France. In Science, 2009
results indicate that MafB/c-MafB deficiency renders self-renewal compatible with terminal differentiation in macrophages
Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.
Pechhold et al., Bethesda, United States. In Nat Biotechnol, 2009
Some beta cells from pregnant animals were found to express Mafb, previously observed only in immature beta cells during embryonic development.
A vertebrate Polycomb response element governs segmentation of the posterior hindbrain.
Cordes et al., Toronto, Canada. In Cell, 2009
Here we have identified a vertebrate PRE, PRE-kr, that regulates expression of the mouse MafB/Kreisler gene.
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Sieweke et al., Marseille, France. In Cell, 2009
Results point to a role for MafB in the maintenance of a balanced lineage potential of hematopoietic stem cells by selectively restricting myeloid commitment divisions that give rise to PU.1+ progenitors in response to M-CSF signaling.
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