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MAD2 mitotic arrest deficient-like 1

Mad2, Mxi1
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Bub1, Smad1, c-Myc, Cdc20
Papers using Mad2 antibodies
Reversal of vinblastine resistance in human leukemic cells by haloperidol and dihydrohaloperidol
Panda Dulal et al., In BMC Cancer, 2000
... Rabbit polyclonal anti-Mad2 IgG was purchased from Bethyl laboratories (Montgomery, USA) ...
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
Kellermayer Miklos S., In PLoS ONE, 1999
... Rabbit anti-Mad2 IgG was purchased from Bethyl laboratories, Montgomery, USA ...
Papers on Mad2
The mammalian autophagy initiator complex contains 2 HORMA domain proteins.
Weiergräber et al., Jülich, Germany. In Autophagy, Nov 2015
Both structural properties and biophysical evidence indicate that ATG101 is locked in this conformation, in contrast to the prototypical HORMA domain protein MAD2.
Identification of potential therapeutic target genes and mechanisms in non-small-cell lung carcinoma in non-smoking women based on bioinformatics analysis.
Na et al., Yinchuan, China. In Eur Rev Med Pharmacol Sci, Sep 2015
DEGs including hyaluronan-mediated motility receptor (HMMR), collagen, type I alpha 2 (COL1A2), cyclin A2 (CCNA2), MAD2 mitotic arrest deficient-like 1 (MAD2L1), interleukin 6 (IL6) and interleukin 1, beta (IL1B) were identified in these functions.
Genome-wide expression and methylation profiles reveal candidate genes and biological processes underlying synovial inflammatory tissue of patients with osteoarthritis.
Wang et al., Linyi, China. In Int J Rheum Dis, Sep 2015
Genes such as CDK1 (cyclin-dependent kinase 1) and MAD2L1 (MAD2 mitotic arrest deficient-like 1) were highlighted in PPI and the miRNA regulatory network.
Dissecting the roles of human BUB1 in the spindle assembly checkpoint.
Kops et al., Utrecht, Netherlands. In J Cell Sci, Sep 2015
Unattached kinetochores catalyze the formation of a diffusible APC/C(CDC20) inhibitor that comprises BUBR1 (also known as BUB1B), BUB3, MAD2 (also known as MAD2L1) and a second molecule of CDC20.
Comparison of the effects of BPA and BPAF on oocyte spindle assembly and polar body release in mice.
Tanemura et al., Sendai, Japan. In Zygote, May 2015
Oocytes cultured in the presence of BPA or BPAF (50 μg/ml) for 21 h were tested for the localization of α-tubulin and MAD2 using immunofluorescence.
A role of WT1 in cell division and genomic stability.
Roberts et al., Buffalo, United States. In Cell Cycle, 2014
Recently we have found that WT1 can regulate the fidelity of chromosome segregation through its interaction with the spindle assembly checkpoint protein, Mitotic arrest deficient-2 (MAD2).
The HORMA domain: an evolutionarily conserved domain discovered in chromatin-associated proteins, has unanticipated diverse functions.
Ghodke et al., Bengaluru, India. In Gene, 2014
The HORMA domain (for Hop1p, Rev7p and MAD2) was discovered in three chromatin-associated proteins in the budding yeast Saccharomyces cerevisiae.
The spindle assembly checkpoint works like a rheostat rather than a toggle switch.
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2013
Instead, the strength of the SAC depends on the amount of MAD2 recruited to kinetochores and on the amount of MCC formed.
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation.
Di Leonardo et al., Palermo, Italy. In J Cell Physiol, 2012
Finally, our results provides an explanation of how a p53 controlled pathway, involving initially p21(waf1) and then p14ARF, could minimize the occurrence of genomic alterations derived from chromosome instability induced by low amounts of MAD2 protein
MAX and MYC: a heritable breakup.
Robledo et al., Madrid, Spain. In Cancer Res, 2012
This finding also confirms the importance of impairment of the MYC/MAX/MXD1 axis in the development of aggressive neural tumors, because MYCN overexpression is an established genetic hallmark of malign neuroblastoma, and it is likely that MXI1 plays a relevant role in the development of medulloblastoma and glioblastoma.
Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.
Compton et al., United States. In Curr Biol, 2012
The data reveal a new function for Mad2 to stabilize kinetochore-microtubule (k-MT) attachments independent of the mitotic checkpoint and explain why Mad2 overexpression increases chromosome missegregation to cause chromosomal instability in human tumors.
A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens.
King et al., Boston, United States. In Nat Methods, 2012
GESS analysis revealed a prominent off-targeted transcript in several screens, including MAD2 (MAD2L1) in a screen for genes required for the spindle assembly checkpoint.
Over-expression of Mxi1 represses renal epithelial tubulogenesis through the reduction of matrix metalloproteinase 9.
Park et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
The results support the suggestion that over-expression of Mxi1 can suppress renal epithelial tubulogenesis.
Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.
Hardwick et al., Edinburgh, United Kingdom. In Curr Biol, 2012
A kinase-dead allele of the fission yeast MPS1 homolog (Mph1) is checkpoint defective and levels of anaphase promoting complex-associated Mad2 and Mad3 are dramatically reduced in this mutant.
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
Sen et al., Houston, United States. In Cancer Cell, 2012
Aurora-A phosphorylated p73 also facilitates inactivation of SAC through dissociation of the MAD2-CDC20 complex in cells undergoing mitosis.
Mad2 and Mad3 cooperate to arrest budding yeast in mitosis.
Murray et al., Cambridge, United States. In Curr Biol, 2012
Mad3 is required for the stable binding of Mad2 to Cdc20 in vivo, which is sufficient to inhibit APC activity and is the most downstream event in spindle checkpoint activation.
Caspase-independent mitotic death (CIMD).
Niikura et al., Memphis, United States. In Cell Cycle, 2008
In BUB1-deficient (but not MAD2-deficient) cells, CIMD is induced by conditions that activate the spindle checkpoint (i.e., cold shock or treatment with nocodazole, paclitaxel or 17-AAG [17-allylaminogeldanamycin]).
Taxanes, microtubules and chemoresistant breast cancer.
McCann et al., Dublin, Ireland. In Biochim Biophys Acta, 2008
Since spindle microtubules are the primary drug targets for taxanes, important SAC proteins such as MAD2, BUBR1, Synuclein-gamma and Aurora A have emerged as potentially important predictive markers of taxane resistance, as have specific checkpoint proteins such as BRCA1.
Flies without a spindle checkpoint.
Karess et al., Gif-sur-Yvette, France. In Nat Cell Biol, 2007
Mad2 has a key role in the spindle-assembly checkpoint (SAC) - the mechanism delaying anaphase onset until all chromosomes correctly attach to the spindle.
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Semenza et al., Baltimore, United States. In Cancer Cell, 2007
Second, HIF-1 promotes MXI-1-independent, proteasome-dependent degradation of C-MYC.
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