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Microtubule-actin crosslinking factor 1

MACF1, ACF7, microtubule-actin crosslinking factor, microtubule-actin crosslinking factor 1
The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, BPAG1, iMpact, CAN, EB1
Papers on MACF1
Microtubule-Actin Cross-Linking Factor 1: Domains, Interaction Partners, and Tissue-Specific Functions.
Liem et al., New York City, United States. In Methods Enzymol, Dec 2015
Among the large number of cytoskeleton-associated proteins characterized to date, microtubule-actin cross-linking factor 1 (MACF1) is arguably the most versatile integrator and modulator of cytoskeleton-related processes.
MACF1, a versatile spectraplakin: isoforms, unique structures, and functions.
Qian et al., Xi'an, China. In Bmb Rep, Dec 2015
Microtubule actin crosslinking factor 1 (MACF1), also termed actin crosslinking family 7 (ACF7), is a member of spectraplakin family and is widely expressed in numerous tissues and cells.
Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain.
Kim et al., Omaha, United States. In Mol Neurobiol, Dec 2015
Here, we show that microtubule-actin crosslinking factor 1 (MACF1) regulates dendritic arborization and axon outgrowth of developing pyramidal neurons by arranging cytoskeleton components and mediating GSK-3 signaling.
Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells.
Qian et al., Xi'an, China. In Bmb Rep, Oct 2015
Microtubule actin crosslinking factor 1 (MACF1), a widely expressed cytoskeletal linker, plays important roles in various cells by regulating cytoskeleton dynamics.
Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma.
Ye et al., Seoul, South Korea. In Hepatology, Oct 2015
Long-term silencing of CD133 by a lentiviral-based approach inhibited cancer cell-cycle progression and suppressed in vivo tumorigenicity by down-regulating expression of cytokinesis-related genes, such as TACC1, ACF7, and CKAP5.
Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.
Li et al., Chengdu, China. In Sci Rep, 2014
Moreover, four genes (LRP1, MACF1, DICER1 and ABCA2) harboring the damaging de novo mutations are strongly prioritized as susceptibility genes by multiple evidences.
Plakins, a versatile family of cytolinkers: roles in skin integrity and in human diseases.
Borradori et al., Bern, Switzerland. In J Invest Dermatol, 2014
Here we review the characteristics of the mammalian plakin members BPAG1 (bullous pemphigoid antigen 1), desmoplakin, plectin, envoplakin, epiplakin, MACF1 (microtubule-actin cross-linking factor 1), and periplakin, highlighting their role in skin homeostasis and diseases.
Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β.
Fuchs et al., New York City, United States. In Cell, 2011
Study identified a link between GSK3beta and ACF7 and further reveal the in vivo relevance of this connection in polarized locomotion of skin stem cells upon injury.
Cell migration: GSK3β steers the cytoskeleton's tip.
Oro et al., Stanford, United States. In Cell, 2011
(2011) demonstrate that the glycogen synthase kinase 3β (GSK3β) controls microtubule architecture and polarized movement of skin stem cells during wound healing in mammals by regulating the microtubule crosslinking protein ACF7.
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Badache et al., Marseille, France. In Proc Natl Acad Sci U S A, 2010
ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2.
Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain.
Liem et al., United States. In Mol Cell Neurosci, 2010
Our data suggest a critical role for MACF1 in neuronal migration that is dependent on its ability to interact with both microfilaments and microtubules.
Plakins in striated muscle.
Boudreau-Larivière et al., Greater Sudbury, Canada. In Muscle Nerve, 2010
Among these proteins are crosslinkers belonging to the plakin family, namely plectin, microtubule-actin crosslinking factor (ACF7/MACF1), bullous pemphigoid antigen 1 (Bpag1/dystonin), and desmoplakin.
Large gradient high magnetic field affects the association of MACF1 with actin and microtubule cytoskeleton.
Shang et al., Xi'an, China. In Bioelectromagnetics, 2009
In conclusion, LG-HMF affects osteoblast-like cell viability, MACF1 distribution, expression, and its association with cytoskeleton to some extent.
Mouse ACF7 and drosophila short stop modulate filopodia formation and microtubule organisation during neuronal growth.
Prokop et al., Manchester, United Kingdom. In J Cell Sci, 2009
Mouse ACF7 and Drosophila Short stop modulate filopodia formation and microtubule organisation during neuronal growth.
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.
Fuchs et al., New York City, United States. In Cell, 2008
ACF7 deficiency compromises the targeting of microtubules along F-actin to focal adhesions (FAs), stabilizes FA-actin networks, and impairs epidermal migration.
Spectraplakins: the cytoskeleton's Swiss army knife.
Brown, Cambridge, United Kingdom. In Cell, 2008
In this issue, Wu et al. (2008) demonstrate a new actin-dependent ATPase activity for the spectraplakin ACF7 that allows it to guide microtubule ends along actin stress fibers to focal adhesions, promoting disassembly of adhesion contacts and hence cell movement.
Plakins in development and disease.
Liem et al., Amsterdam, Netherlands. In Exp Cell Res, 2007
Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons.
Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.
Kerr, London, United Kingdom. In J Vet Med B Infect Dis Vet Public Health, 2005
Six genes were found to be differentially expressed with roles in the cytoskeleton (SKIP, MACF1, SPAG7, FLOT1), integrin signalling (FLOT1, RASSF5), HLA class III (c6orf48), and tumour suppression (RASSF5).
ACF7: an essential integrator of microtubule dynamics.
Fuchs et al., New York City, United States. In Cell, 2003
In ACF7's absence, microtubules still bind EB1 and CLIP170, but they no longer grow along polarized actin bundles, nor do they pause and tether to actin-rich cortical sites.
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