GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Mab-21-like 1
Mab21l1, mab-21, CAGR1
This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5' UTR may play a role in a variety of psychiatric disorders. [provided by RefSeq, Oct 2008] (from
NCBI)
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Top mentioned proteins:
FATE, TUBE, CAN, ACID, TGF-beta
Papers on
Mab21l1
Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity.
New York City, United States. In Bmc Neurosci, 2014
We further show that some proposed mechanisms of DAPK's action (modulation of synaptic strength, involvement of the DANGER-related protein MAB-21, and autophagy) do not have a major role in nematode excitotoxicity.
Mutations in MAB21L2 result in ocular Coloboma, microcornea and cataracts.
Milwaukee, United States. In Plos Genet, 2014
MAB21L2 encodes a protein similar to C. elegans mab-21 cell fate-determining factor; the molecular function of MAB21L2 is largely unknown.
Xmab21l3 mediates dorsoventral patterning in Xenopus laevis.
New York City, United States. In Mech Dev, 2012
Misexpression of Xenopus mab21-like 3 (Xmab21l3) dorsalizes gastrula-stage mesoderm and neurula-stage ectoderm, while morpholino-mediated knockdown of Xmab21l3 inhibits dorsal differentiation of these embryonic germ layers.
PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway.
GeneRIF
South Korea. In J Cell Biochem, 2011
MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression.
mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation.
GeneRIF
Dublin, Ireland. In Dev Dyn, 2011
Despite the absence of conserved non-coding elements, a 4.9-kb mab21l2 promoter is sufficient to recapitulate expression in tissues unique to mab21l1 or mab21l2.
Expression of ventral diencephalon-enriched genes in zebrafish.
GeneRIF
Shanghai, China. In Dev Dyn, 2010
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
Death-associated protein kinase-mediated cell death modulated by interaction with DANGER.
Baltimore, United States. In J Neurosci, 2010
We report that DAPK is regulated by DANGER, a partial MAB-21 domain-containing protein.
An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.
Hong Kong, Hong Kong. In Genomics, 2009
A gene-centric paralogous genomic sequence comparison strategy was used in this study to align these paralogous nested pairs, Mab21l2-Lrba and Mab21l1-Nbea, to identify the associated paralogous non-coding elements (pNEs) they shared.
Molecular cytogenetic characterization of an interstitial de novo 13q deletion in a 3-month-old with severe pediatric gastroesophageal reflux.
Galveston, United States. In Am J Med Genet A, 2009
The GERD1 locus has been mapped to a 9-cM interval between the markers CAGR1 and D13S263, both of which are deleted in our patient.
C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development.
Hong Kong, Hong Kong. In Biochem Biophys Res Commun, 2007
Mab21 gene family members are required for embryonic development and sensory organ formation in both invertebrates and vertebrates.
DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.
United States. In J Biol Chem, 2007
DANGER is a membrane-associated protein predicted to contain a partial MAB-21 domain.
Molecular genetic analysis of human homologs of Caenorhabditis elegans mab-21-like 1 gene in patients with neural tube defects.
Genova, Italy. In Birth Defects Res A Clin Mol Teratol, 2004
Antisense studies have implicated murine Mab21 genes as having an important role in neural tube development.
Requirement for Mab21l2 during development of murine retina and ventral body wall.
Ikoma, Japan. In Dev Biol, 2004
The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans.
MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1.
Milano, Italy. In Bmc Cell Biol, 2003
BACKGROUND: Through in vivo loss-of-function studies, vertebrate members of the Male abnormal 21 (mab-21) gene family have been implicated in gastrulation, neural tube formation and eye morphogenesis.
Expression of zebrafish mab21 genes marks the differentiating eye, midbrain and neural tube.
GeneRIF
Hong Kong, Hong Kong. In Mech Dev, 2002
mab21 genes play a role in differentiation of the early differentiating olfactory bulbs, eye primordia, midbrain and subsequently the branchial pouches and neural tube
Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation.
GeneRIF
Hong Kong, Hong Kong. In Teratology, 2002
required in developing embryos for embryonic turning, formation of the notochord, neural tube, and other organ tissues
The unstable trinucleotide repeat story of major psychosis.
Review
Toronto, Canada. In Am J Med Genet, 1999
A fourth, but much more infrequently unstable CAG/CTG repeat has been identified within the 5' untranslated region of the gene, MAB21L1, on 13q13.
