DEL1 - a new player in periodontal disease?
Toronto, Canada. In Oral Dis, Feb 2016
Osteoblasts (as well as osteocytes and stromal cells) secrete two key molecules, macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANKL), which activate the fusion of the mononuclear precursors to form mature multinucleated osteoclasts.
Multi-analyte profiling in human carotid atherosclerosis uncovers pro-inflammatory macrophage programming in plaques.
Oxford, United Kingdom. In Thromb Haemost, Feb 2016
The in vitro production of a specific network of mediators was found to be significantly higher in symptomatic than asymptomatic plaques, including: tumour necrosis factor α, interleukin (IL) 1β, IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), CCL5, CCL20, CXCL9, matrix metalloproteinase (MMP)-3 and MMP-9.
Cytokines and Blastocyst Hatching.
Bengaluru, India. In Am J Reprod Immunol, Jan 2016
Pro-inflammatory (IL-6, LIF, GM-CSF) and anti-inflammatory (IL-11, CSF-1) cytokines improve hatching rates; they modulate proteases (MMPs, tPAs, cathepsins and ISP1).
The role of inflammation in progression of breast cancer: Friend or foe? (Review).
London, United Kingdom. In Int J Oncol, Sep 2015
Recent successes of PD-1 blockade in treating multiple cancers, and new developments with other immune targets such as CTLA-4 and CSF-1 inhibitors, highlight that it is becoming ever more important that we understand the complexity of the immune and inflammatory systems in the development and progression of breast cancer.
Therapeutic targeting of macrophages in lupus nephritis.
United States. In Discov Med, Jul 2015
The current literature explores targeting macrophages by several different means, including the CSF-1/CSF-1R signaling axis, the CX3CL1/CX3CR1 signaling axis, the CCL2/CCR2 signaling axis, and Bruton's Tyrosine Kinase (BTK), all of which hold promise as targets for future LN treatments.
M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.
Marseille, France. In Nature, 2013
Here we show that macrophage colony-stimulating factor (M-CSF, also called CSF1), a myeloid cytokine released during infection and inflammation, can directly induce the myeloid master regulator PU.1 and instruct myeloid cell-fate change in mouse HSCs, independently of selective survival or proliferation.
Osteoclasts: New Insights.
Birmingham, United States. In Bone Res, 2013
Osteoclasts differentiate from cells of the monocyte/macrophage lineage upon stimulation of two essential factors, the monocyte/macrophage colony stimulating factor (M-CSF) and receptor activation of NF-κB ligand (RANKL).