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Tumor-associated calcium signal transducer 2

M-1s-1, GA733, TROP2, TACSTD2
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: CAN, CD45, HAD, ACID, POLYMERASE
Papers on M-1s-1
TROP2 overexpression promotes proliferation and invasion of lung adenocarcinoma cells.
Zhang et al., Nanchang, China. In Biochem Biophys Res Commun, Feb 2016
UNASSIGNED: Recent studies suggest that the human trophoblast cell-surface antigen TROP2 is highly expressed in a number of tumours and is correlated with poor prognosis.
Trop2 is overexpressed in gastric cancer and predicts poor prognosis.
Zhu et al., Nanjing, China. In Oncotarget, Jan 2016
UNASSIGNED: The cell surface protein Trop2 is overexpressed in a variety of human cancers.
siRNA targeting of Trop2 suppresses the proliferation and invasion of lung adenocarcinoma H460 cells.
Jiang et al., Taizhou, China. In Exp Ther Med, Aug 2015
UNASSIGNED: The aim of the present study was to investigate the effect of the small interfering RNA (siRNA)-induced inhibition of the Trop2 gene on the proliferation and invasion of lung adenocarcinoma H460 cells.
Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications.
Bonavida et al., Los Angeles, United States. In Genes Cancer, Mar 2015
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene.
Trop2: from development to disease.
Wallace et al., In Dev Dyn, Feb 2015
BACKGROUND: Trop2 was first discovered as a biomarker of invasive trophoblast cells.
Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma.
Puapairoj et al., Khon Kaen, Thailand. In Ann Hepatol, 2015
BACKGROUND AND AIM: Trophoblast cell surface antigen 2 (TROP2) or tumor-associated calcium signal transducer 2 (TACSTD2) is a 36-kDa type I transmembrane glycoprotein and exerts dual functions as an oncogene and tumor suppressor in cancer cells.
Prognostic value of TROP2 in human nasopharyngeal carcinoma.
Zheng et al., Changchun, China. In Int J Clin Exp Pathol, 2014
BACKGROUND: There is increasing evidence demonstrating the role of human trophoblast cell surface antigen 2 (TROP2) in cancer development and progression.
EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer.
Disseminated Cancer Cell Network (DCC Net) Duesseldorf et al., Düsseldorf, Germany. In Plos One, 2014
The expression of respective proteins (Trop2, CD49f, c-Met, CK8, CD44, ADAM8, CD146, TEM8, CD47) was verified by immunofluorescence on EpCAMpos (e.g.
Optimization of Ammonium Sulfate Concentration for Purification of Colorectal Cancer Vaccine Candidate Recombinant Protein GA733-FcK Isolated from Plants.
Ko et al., Seoul, South Korea. In Front Plant Sci, 2014
With 50% ammonium sulfate, the yield of precipitated TSP was the highest, and that of the plant-derived colorectal cancer-specific surface glycoprotein GA733 fused to the Fc fragment of human IgG tagged with endoplasmic reticulum retention signal KDEL (GA733(P)-FcK) protein significantly increased 1.8-fold.
Prognostic biomarkers in patients with resected cholangiocarcinoma: a systematic review and meta-analysis.
van Gulik et al., Amsterdam, Netherlands. In Ann Surg Oncol, 2014
Other markers showed promising results in single studies, including HSP27, Akt, HDGF, MUC6, p16, p-4EBP1, S100A4, α-SMA, Keratin 903, and TROP2.
Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis.
Languino et al., Philadelphia, United States. In J Cell Physiol, 2012
our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis
Gelatinous drop-like corneal dystrophy.
Tsujikawa, Ōsaka, Japan. In Cornea, 2012
We identified the gene responsible for GDLD, tumor-associated calcium signal transducer 2 (TACSTD2), by positional cloning and detected 4 disease-causing mutations in Japanese patients with GDLD.
TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.
Yang et al., Taipei, Taiwan. In Embo Mol Med, 2012
Inactivation of TROP2 due to loss of heterozygosity or by DNA methylation may play an important role in lung cancer tumourigenicity through losing its suppressive effect on IGF-1R signalling and tumour growth.
Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass.
Relton et al., Newcastle upon Tyne, United Kingdom. In Diabetes, 2012
TACSTD2 expression was inversely correlated with methylation (P=0.016), and both measures were associated with fat mass (expression, P=0.049; methylation, P=0.037)
(89)Zr-Desferrioxamine-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody
Leung, Bethesda, United States. In Unknown Journal, 2012
Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).
Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-β1-dependent human epidermal Langerhans cells.
Strobl et al., Vienna, Austria. In J Invest Dermatol, 2011
TROP2 (TACSTD2), an EpCAM-like molecule, is a specific marker for TGF-beta1-dependent human epidermal Langerhans cells
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody.
Santin et al., New Haven, United States. In J Exp Clin Cancer Res, 2010
Trop-2 is overexpressed in a proportion of human uterine (UMMT) and ovarian (OMMT) carcinosarcoma.
Ectopic expression of guanylyl cyclase C in CD34+ progenitor cells in peripheral blood.
Waldman et al., Philadelphia, United States. In J Clin Oncol, 2001
Moreover, CD34+ progenitor cells expressed other epithelial cell-specific markers, including prostate-specific antigen, prostate-specific membrane antigen, carcinoembryonic antigen, CK-19, CK-20, mucin 1, and GA733.2.
Identification of the gene responsible for gelatinous drop-like corneal dystrophy.
Nakamura et al., Ōsaka, Japan. In Nat Genet, 1999
Here we report DNA sequencing, cDNA cloning and mutational analyses of four deleterious mutations (Q118X, 632delA, Q207X and S170X) in M1S1 (formerly TROP2 and GA733-1), encoding a gastrointestinal tumour-associated antigen.
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