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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cholinergic receptor, muscarinic 1

m-1, HM1
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, BST2, OUT
Papers on m-1
Novel aryl carbamate derivatives of metronidazole as potential antiamoebic agents.
Shin et al., Inch'ŏn, South Korea. In Arch Pharm Res, Jan 2016
As compared to MNZ, most of the derivatives exhibited moderate to excellent activity against the HM1:IMSS strain of Entamoeba histolytica.
Characterization of a human isolate of Tritrichomonas foetus (cattle/swine genotype) infected by a zoonotic opportunistic infection.
Iwata et al., Tokyo, Japan. In J Vet Med Sci, Jan 2016
Moreover, inoculation via orogastric intubation caused infection in the cecum on Day 5 in CBA mice co-infected with Entamoeba histolytica (HM-1: IMSS cl6).
Human parainfluenza virus type 2 V protein inhibits and antagonizes tetherin.
Nishio et al., In J Gen Virol, Jan 2016
UNASSIGNED: Tetherin (BST-2/CD317/HM1.24) is an antiviral membrane protein that prevents the release of enveloped viruses from the cell surface.
Comparison of the Anaerocult A and the oil blocking methods for the in vitro cultivation of Entamoeba histolytica.
Suhaimi et al., Kuala Selangor, Malaysia. In Malays J Pathol, Dec 2015
The trophozoites of E. histolytica HM1: IMSS strains were axenically cultivated in TYI-S-33 medium in culture incubated anaerobically by using Anaerocult A (Merck) and mineral oil blocking method.
A systematic review and meta-analysis on outcomes after Rx or R1 endoscopic resection of superficial gastric cancer.
Dinis-Ribeiro et al., Porto, Portugal. In Eur J Gastroenterol Hepatol, Nov 2015
However, nonevaluable (HMx) and positive horizontal margins (HM1) were associated with 10% [95% confidence interval (CI) 5-15%] and 36% (95% CI 24-48%) rates of recurrence/residual disease, respectively, with an odds ratio of 2.85 (95% CI 1.6-5.8,
Molecular biology research to benefit patients with Entamoeba histolytica infection.
Petri et al., Charlottesville, United States. In Mol Microbiol, Oct 2015
Moreover, in vitro experiments have predominantly been performed using the same axenic cultured strain HM-1: IMSS isolated about 50 years ago, whereas highly diverse strains are prevalent all over the world.
T cell-based targeted immunotherapies for patients with multiple myeloma.
Schmitt et al., Heidelberg, Germany. In Int J Cancer, May 2015
Besides a comprehensive list of tumor antigens for T cell-based approaches, eight promising antigens, CS1, Dickkopf-1, HM1.24, Human telomerase reverse transcriptase, MAGE-A3, New York Esophageal-1, Receptor of hyaluronic acid mediated motility and Wilms' tumor gene 1, are described in detail to provide a background for potential clinical use.
Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells.
Wright et al., Atlanta, United States. In J Virol, 2014
UNLABELLED: Tetherin (BST2, CD317, or HM1.24) is a host cellular restriction factor that prevents the release of enveloped viruses by mechanically linking virions to the plasma membrane.
Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity
Lindsley et al., Bethesda, United States. In Unknown Journal, 2014
A recently completed functional, high throughput screen of the Molecular Libraries Probe Production Centers Network (MLPCN) screening deck of ∼360,000 compounds conducted by Scripps Research Institute Molecular Screening Center (SRIMSC) against three of the five muscarinic receptor subtypes (M1, M4 and M5) provided a number of interesting hits.
Development of the First Potent, Selective and CNS penetrant M5 Negative Allosteric Modulator (NAM)
Lindsley et al., Bethesda, United States. In Unknown Journal, 2014
A recently completed functional, high throughput screen of the Molecular Libraries Probe Production Center's Network (MLPCN) screening deck of ∼360,000 compounds conducted by Scripps Research Institute Molecular Screening Center (SRIMSC) against three of the five muscarinic receptor subtypes (M1, M4 and M5) provided a number of interesting hits.
Muscarinic M1 receptor sequence: preliminary studies on its effects on cognition and expression.
Dean et al., Australia. In Schizophr Res, 2012
CHRM1 sequence is associated with alterations in some aspects of executive function. Post-mortem study indicates this is not simply due to altered expression at the mRNA level, suggesting sequence alteration may affect the functionality of the CHRM1.
M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation.
Zhang et al., Xiamen, China. In Neurosci Lett, 2012
Here we found that M1 Muscarinic acetylcholine receptor (M1 mAChR), an important G protein-coupled receptor involved in cholinergic neuronal activity, can interact with BACE1 and mediate its proteosomal degradation.
A specific multi-nutrient formulation enhances M1 muscarinic acetylcholine receptor responses in vitro.
Broersen et al., Wageningen, Netherlands. In J Neurochem, 2012
Binding properties of human muscarinic M1 receptor in stably transfected Chinese hamster ovary cells is significantly enhanced after supplementation, probably by facilitating receptor-mediated G protein activation.
FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.
Challiss et al., Leicester, United Kingdom. In Plos One, 2011
Data show that CFP/YFP-M(1) mAChR chimera expressed predominantly at the plasma membrane .
Interpreting the structural mechanism of action for MT7 and human muscarinic acetylcholine receptor 1 complex by modeling protein-protein interaction.
Chen et al., Shanghai, China. In J Biomol Struct Dyn, 2011
The binding mode of MT7 and human muscarinic acetylcholine receptor 1 consists of three interaction regions in five residue interaction clusters.
Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.
Bieniasz et al., New York City, United States. In Nature, 2008
Using deductive constraints and gene expression analyses, we identify CD317 (also called BST2 or HM1.24), a membrane protein of previously unknown function, as a tetherin.
Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits.
Macara et al., Burlington, United States. In Nature, 1996
In NIH-3T3 cells expressing subtype 1 human muscarinic receptors (hm1), the agonist carbachol selectively increased the specific activity and phosphorylation state of epitope-tagged Ras-GRF.
Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning.
Melton et al., Edinburgh, United Kingdom. In Nat Genet, 1993
Mice with defective DNA repair were generated by targeting the excision repair cross complementing gene (ERCC-1) in the embryonic stem cell line, HM-1.
Activation of complement by an IgG molecule without a genetic hinge.
Sandlie et al., Oslo, Norway. In Nature, 1993
Here we report the construction of a hinge-deleted mouse-human chimaeric IgG3 molecule with specificity for the hapten NIP (3-iodo-4-hydroxy-5-nitrophenacetyl), HM-1.
Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes.
Capon et al., San Francisco, United States. In Nature, 1988
In contrast, the HM1 and HM4 mAChRs strongly activate PI hydrolysis, but do not inhibit adenylyl cyclase, and in fact can substantially elevate cAMP levels.
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