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Acid phosphatase 2, lysosomal

lysosomal acid phosphatase
catalyzes the hydrolysis of p-nitrophenyl phosphate; may play a role in synaptic transmission [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, LAP, CAN, beta-glucuronidase, HAD
Papers on lysosomal acid phosphatase
Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse.
Marzban et al., Winnipeg, Canada. In Int J Mol Sci, 2014
Spontaneous mutation in the lysosomal acid phosphatase 2 (Acp2) mouse (nax-naked-ataxia mutant mouse) correlates with severe cerebellar defects including ataxia, reduced size and abnormal lobulation as well as Purkinje cell (Pc) degeneration.
[Peculiarities of clinical and metabolic adaptation of newborns extracted by repeated cesarean section].
Gasanov et al., In Georgian Med News, 2014
It was found that neonatal exposure to PCB on the cell membrane and intracellular structures is accompanied by high activity of the lysosomal acid phosphatase marker and low activity of mitochondrial enzymes SDG and GDG.
Cytotoxicity and cellular mechanisms involved in the toxicity of CdS quantum dots in hemocytes and gill cells of the mussel Mytilus galloprovincialis.
Cajaraville et al., Spain. In Aquat Toxicol, 2014
The mechanisms of action of CdS QDs were assessed at sublethal concentrations (0.31-5 mg Cd/L) in the same cell types through a series of functional in vitro assays: production of reactive oxygen species (ROS), catalase (CAT) activity, DNA damage, lysosomal acid phosphatase (AcP) activity, multixenobiotic resistance (MXR) transport activity, Na-K-ATPase activity (only in gill cells) and phagocytic activity and damage to actin cytoskeleton (only in hemocytes).
Proteomic analysis of the Ehrlichia chaffeensis phagosome in cultured DH82 cells.
Yu et al., Chongqing, China. In Plos One, 2013
Lysosomal proteins such as cathepsin D, cathepsin S, and lysosomal acid phosphatase were not detected in E. chaffeensis phagosome preparations.
Spatial and temporal expression of lysosomal acid phosphatase 2 (ACP2) reveals dynamic patterning of the mouse cerebellar cortex.
Marzban et al., Winnipeg, Canada. In Cerebellum, 2013
The Acp2 gene encodes lysosomal acid phosphatase 2 (ACP2), an isoenzyme that hydrolyzes orthophosphoric monoesters to alcohol and phosphate.
Purkinje cell compartmentation in the cerebellum of the lysosomal Acid phosphatase 2 mutant mouse (nax - naked-ataxia mutant mouse).
Marzban et al., Winnipeg, Canada. In Plos One, 2013
The Acp2 gene encodes the beta subunit of lysosomal acid phosphatase, which is an isoenzyme that hydrolyzes orthophosphoric monoesters.
Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells.
Redmond et al., Madison, United States. In Mol Vis, 2013
The specific activity of cathepsin D and lysosomal acid phosphatase was reduced in the A2E-treated cells, but ROS degradation was not impaired.
Current concepts of enzyme histochemistry in modern pathology.
Bruder et al., Basel, Switzerland. In Pathobiology, 2007
Enzyme histochemical increase in lysosomal acid phosphatase activity is an early marker of ischemic tissue lesions.
Procoagulant potential of platelet alpha granules.
Polasek, Toronto, Canada. In Platelets, 2004
There is also demasking of lysosomal acid phosphatase activity and microvesicle formation.
Tartrate-resistant acid phosphatase knockout mice.
Cox et al., Bristol, United Kingdom. In J Bone Miner Res, 2003
The macrophages lacking TRACP showed an increase in tartrate-sensitive lysosomal acid phosphatase activity (LAP).
Clinical and biological aspects of acid phosphatase.
Wile et al., London, United Kingdom. In Crit Rev Clin Lab Sci, 1994
The prostatic form has long been used as a marker for prostatic cancer and the macrophagic forms have been linked with miscellaneous disorders, notably increased osteolysis, Gaucher's disease of spleen, and hairy cell leukemia, whereas the normal levels of intravesical lysosomal acid phosphatase in I cell disease pointed the way toward the mechanisms underlying its intracellular processing.
Biogenesis of lysosomal membranes.
von Figura et al., Göttingen, Germany. In Febs Lett, 1994
Besides resident proteins the lysosomal membrane harbours at least one transient passenger, lysosomal acid phosphatase, which is sorted as a membrane-bound precursor like resident lysosomal membrane proteins and liberated from the membrane by limited proteolysis upon arrival in dense lysosomes.
The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation.
Gierasch et al., Dallas, United States. In Cell, 1992
With the results presented in the accompanying paper on lysosomal acid phosphatase, we now have direct evidence for previous proposals of a general correlation of internalization signals with a turn conformational motif.
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn.
Peters et al., Heidelberg, Germany. In Cell, 1992
For rapid endocytosis lysosomal acid phosphatase requires a Tyr-containing signal in its cytoplasmic domain, as do cell surface receptors mediating endocytosis and clustering in coated pits.
Human acid phosphatase in somatic cell hybrids.
Gerald et al., In Science, 1974
The human enzyme, lysosomal acid phosphatase ACP2, is expressed in nan-rodent somatic cell hybrids as a dimeric molecule.
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