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Lymphotoxin alpha

Lymphotoxin-alpha, TNF-beta, LTA
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.[provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: ACID, TLR2, CAN, HAD, Interleukin-6
Papers using Lymphotoxin-alpha antibodies
Arginine 104 Is a Key Catalytic Residue in Leukotriene C4 Synthase*
Haeggström Jesper Z. et al., In The Journal of Biological Chemistry, 1999
... LTA4 methyl ester (BIOMOL) in tetrahydrofuran was saponified ...
Papers on Lymphotoxin-alpha
Impact of residual platelet reactivity on reperfusion in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Tamburino et al., Catania, Italy. In Eur Heart J Acute Cardiovasc Care, Feb 2016
Light transmission aggregometry (LTA) was performed in a subgroup.
Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells.
Burnham et al., Denver, United States. In Am J Physiol Lung Cell Mol Physiol, Feb 2016
We sought to determine the relationship of AUDs and smoking to expression of interferon (IFN)-γ, IL-1β, IL-6, and tumor necrosis factor (TNF)-α by AMs and PBMCs from human subjects after stimulation with either lipopolysaccharide (LPS) or lipoteichoic acid (LTA).
Identification and characterization of an apoptosis-stimulating protein of p53 (ASPP) gene from Branchiostoma belcheri: Insights into evolution of ASPP gene family.
Ma et al., Qingdao, China. In Fish Shellfish Immunol, Jan 2016
In addition, the amphioxus ASPP gene was ubiquitously and differentially expressed in five investigated tissues, and the amphioxus ASPP gene was involved in the innate immune response of LPS and LTA stimulation.
Staphylococcal LTA-induced miR-143 inhibits Propionibacterium acnes-mediated inflammatory response in skin.
Lai et al., Shanghai, China. In J Invest Dermatol, Jan 2016
Staphylococcal LTA activated TLR2 to induce miR-143 in keratinocytes, and miR-143, in turn, directly targeted 3' UTR of TLR2 to decrease the stability of TLR2 mRNA and then decreased TLR2 protein, thus inhibiting P. acnes-induced pro-inflammatory cytokines.
Structural variations of the cell wall precursor lipid II in Gram-positive bacteria - Impact on binding and efficacy of antimicrobial peptides.
Sahl et al., Wuppertal, Germany. In Biochim Biophys Acta, Nov 2015
Typically, AMPs are cationic and amphiphilic and first contacts with target microbes involve interactions with negatively charged components of the cell envelope such as lipopolysaccharide (LPS), and wall- or lipoteichoic acids (WTA, LTA).
An intimate link between antimicrobial peptide sequence diversity and binding to essential components of bacterial membranes.
Destoumieux-Garzón et al., Valparaíso, Chile. In Biochim Biophys Acta, Nov 2015
Thus, lipopolysaccharides (LPS), lipoteichoic acids (LTA) and the peptidoglycan precursor Lipid II are targeted by a broad series of AMPs.
Simultaneous Liver-Kidney Transplant: Too Many or Just Enough?
Wiseman et al., Ann Arbor, United States. In Adv Chronic Kidney Dis, Sep 2015
Because kidney recovery after liver transplant alone (LTA) is difficult to predict, indications for SLK are not precisely defined.
Molecular genetics of coronary artery disease.
Tanaka et al., Yokohama, Japan. In J Hum Genet, Aug 2015
To clarify the genetic architecture of MI, we started a genome-wide association study (GWAS) using nearly 100 000 gene-based single-nucleotide polymorphisms (SNPs) from 2000, and identified LTA associated with the increased risk of MI in Japanese population.
Association of lymphotoxin alpha polymorphism with systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis.
Ye et al., Hefei, China. In Int J Rheum Dis, May 2015
AIM: The aim of this study was to perform a meta-analysis of eligible studies to derive precise estimation of the associations of lymphotoxin alpha (LTA) 252 A>G polymorphism (rs909253) with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) risk.
Lysate of Probiotic Lactobacillus plantarum K8 Modulate the Mucosal Inflammatory System in Dextran Sulfate Sodium-induced Colitic Rats.
Kwon et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2013
Recent studies have reported that lipoteichoic acid (LTA) from Lactobacillus plantarum K8 reduces excessive production of pro-inflammatory cytokine.
SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.
Yang et al., Tampa, United States. In Lung Cancer, 2012
single nucleotide polymorphisms within the PTGS2 and LTA inflammatory markers were associated with pain and quality of life in a large sample of long term lung cancer survivors
IL-1β (-511T/C) gene polymorphism not IL-1β (+3953T/C) and LT-α (+252A/G) gene variants confers susceptibility to visceral leishmaniasis.
Abdollahi et al., Fasā, Iran. In Mol Biol Rep, 2012
Lymphotoxin alpha +252A/G polymorphism was not associated with visceral leishamaniasis.
Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice.
LeBoeuf et al., Seattle, United States. In Am J Physiol Endocrinol Metab, 2012
Data from lymphotoxin-alpha knockout mice suggest that lymphotoxin-alpha contributes to diet-induced weight gain and adiposity (leading to obesity) and is required to modulate accumulation of immune cells in adipose tissue (as in obesity).
Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: a pathological study of 1503 consecutive autopsy cases.
Sawabe et al., Tokyo, Japan. In Atherosclerosis, 2012
LTA and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of myocardial infarction.
In vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-disease.
Grogan et al., San Francisco, United States. In Plos One, 2011
In vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-disease.
Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.
Gallo et al., San Diego, United States. In Nat Med, 2009
This inhibition is mediated by staphylococcal lipoteichoic acid (LTA) and acts selectively on keratinocytes triggered through Toll-like receptor 3(TLR3).
Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy.
Abel et al., Paris, France. In Nat Genet, 2007
LTA is a major gene associated with early-onset leprosy.
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
Nieters et al., Bethesda, United States. In Lancet Oncol, 2006
METHODS: We selected 12 single-nucleotide polymorphisms for analysis, on the basis of previous functional or association data, in nine genes that have important roles in lymphoid development, Th1/Th2 balance, and proinflammatory or anti-inflammatory pathways (IL1A, IL1RN, IL1B, IL2, IL6, IL10, TNF, LTA, and CARD15).
Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.
Tanaka et al., Tokyo, Japan. In Nature, 2004
lymphotoxin-alpha binds to galectin-2, a member of the galactose-binding lectin family; link between the LTA cascade and the pathogenesis of myocardial infarction
Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.
Kwiatkowski et al., Oxford, United Kingdom. In Nat Genet, 2004
expression may be genetically regulated by allele-specific recruitment of the transcriptional repressor ABF-1
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