Multiple myeloma: New surface antigens for the characterization of plasma cells in the era of novel agents.
Torino, Italy. In Cytometry B Clin Cytom, Jan 2016
Based on the antigens expression and monoclonal antibody availability, CD150, CD48, CD229, CD352, CD319, CD272, CD86, CD200 and CD184 were subsequently tested in 24 NDMM, 8 relapsed MM (RMM), 6 plasma cell leukemia (PCL) and 13 healthy subjects.
The role of SLAM/CD2 polymorphisms in systemic autoimmunity.
Dallas, United States. In Curr Opin Immunol, 2010
Three members of this gene family, Ly108, Ly9, and CD84, exhibit polymorphisms that strongly influence susceptibility to systemic autoimmunity, notably in mice, but also in some human populations.
SLAM family receptors and SAP adaptors in immunity.
Bethesda, United States. In Annu Rev Immunol, 2010
The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgammaglobulinemia. SAP consists almost entirely of a single SH2 protein domain that interacts with the cytoplasmic tail of SLAM and related receptors, including 2B4, Ly108, CD84, Ly9, and potentially CRACC.
Association of LY9 in UK and Canadian SLE families.
London, United Kingdom. In Genes Immun, 2008
A family-based association study in the United Kingdom and Canada identifies genetic variants in the LY9 promoter and coding region contributing to systemic lupus erythematosus susceptibility.
Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.
Australia. In Annu Rev Immunol, 2006
During the past eight years, it has been established that the SLAM family of cell surface receptors (SLAM, 2B4, NTB-A, Ly9, CD84) and the SAP family of adaptors (SAP, EAT-2, ERT) play critical roles in lymphocyte development, differentiation, and acquisition of effector functions.
Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.
Philadelphia, United States. In Immunol Rev, 2005
SAP is expressed in T cells, natural killer (NK) cells, and NKT cells, where it binds to the cytoplasmic domain of the surface receptor SLAM (CD150) and the related receptors, 2B4 (CD244), CD84, Ly9 (CD229), NK-T-B-antigen, and CD2-like receptor-activating cytotoxic T cells.