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LSM6 Lsm6p

Lsm6, Lsm6p
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: Lsm3p, caspase-3, Lsm1, CAN, Lsm8p
Papers on Lsm6
LSM proteins provide accurate splicing and decay of selected transcripts to ensure normal Arabidopsis development.
Salinas et al., Madrid, Spain. In Plant Cell, 2012
A search of the Arabidopsis thaliana genome identifies 11 genes encoding proteins related to the eight conserved LSMs, the genes encoding the putative LSM1, LSM3, and LSM6 proteins being duplicated.
Network-based gene expression biomarkers for cold and heat patterns of rheumatoid arthritis in traditional chinese medicine.
Lu et al., Beijing, China. In Evid Based Complement Alternat Med, 2011
PRKAA1, HSPA8, and LSM6, which were related to fatty acid metabolism and the I-κB kinase/NF-κB cascade, were significant biomarkers of the TCM heat-pattern of RA.
Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.
Song et al., Singapore, Singapore. In Plos One, 2011
Analysis of the inter-subunit interactions in Lsm5/6/7 reveals the organization order among Lsm5, Lsm6 and Lsm7.
A novel link between Sus1 and the cytoplasmic mRNA decay machinery suggests a broad role in mRNA metabolism.
Rodríguez-Navarro et al., Valencia, Spain. In Bmc Cell Biol, 2009
We provide evidence for genetic interactions between SUS1 and genes coding for components of P-bodies such as PAT1, LSM1, LSM6 and DHH1.
Hypergonadotropic hypogonadism in a patient with inv ins (2;4).
Steinberger et al., Berlin, Germany. In Int J Androl, 2009
In 4q31.22, a breakpoint-spanning clone (RP11-6L6) was identified which contains the genes LSM6 and SLC10A7.
Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment.
Mabbutt et al., Sydney, Australia. In J Mol Biol, 2008
The homomeric Lsm3 octamer is found to successfully recruit Lsm6, Lsm2 and Lsm5 directly from yeast lysate.
Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.
Tollervey et al., Edinburgh, United Kingdom. In Mol Cell Biol, 2004
Here we report that mature heat shock and MET mRNAs that are trapped in the nucleus due to a block in mRNA export were strongly stabilized in strains lacking Lsm6p or the nucleus-specific Lsm8p protein but not by the absence of the cytoplasmic Lsm1p.
The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.
Achsel et al., Göttingen, Germany. In Rna, 2002
LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci
Multiple functional interactions between components of the Lsm2-Lsm8 complex, U6 snRNA, and the yeast La protein.
Wolin et al., New Haven, United States. In Genetics, 2001
Furthermore, deletions of LSM5, LSM6, or LSM7 cause LHP1 to become required for growth.
Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).
Dreyfuss et al., Philadelphia, United States. In J Biol Chem, 2000
Interestingly, SMN also interacts with at least two of the U6-associated Sm-like (Lsm) proteins, Lsm4 and Lsm6.
Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.
Fabrizio et al., Heidelberg, Germany. In Embo J, 1999
These include four Sm-like proteins (Lsm2p, Lsm5p, Lsm6p and Lsm7p) and four specific proteins named Snu13p, Dib1p, Snu23p and Snu66p.
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