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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

LSM1 Lsm1p

Lsm1, Lsm1p, CD45-AP, LPAP, CD45-associated protein
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: caspase-3, CD45, CAN, STEP, Dcp1
Papers using Lsm1 antibodies
Argonaute2 is the catalytic engine of mammalian RNAi
Young John, In PLoS Pathogens, 2003
... Cruz Biotechnology) and α-DDX6 (RCK/p54; Bethyl Laboratories, Montgomery, Texas, United States), and chicken polyclonal antibody α-LSM1 (GenWay Biotech, San Diego, California, United ...
Papers on Lsm1
The LSM1-7 complex differentially regulates Arabidopsis tolerance to abiotic stress conditions by promoting selective mRNA decapping.
Salinas et al., Madrid, Spain. In Plant Cell, Feb 2016
Here, we provide genetic and molecular evidence that a component of the decapping machinery, the LSM1-7 complex, plays a critical role in plant tolerance to abiotic stresses.
Altered functional connectivity in children with mild to moderate TBI relates to motor control.
Suskauer et al., Baltimore, United States. In J Pediatr Rehabil Med, Jan 2016
In children with TBI, greater DMN-RdPM connectivity was associated with worse motor performance whereas greater DAN-LSM1 connectivity was associated with better motor performance; furthermore, DMN-RdPM and DAN-LSM1 connectivity were negatively correlated.
The CaSm (LSm1) oncogene promotes transformation, chemoresistance and metastasis of pancreatic cancer cells.
Cole et al., Charleston, United States. In Oncogenesis, Dec 2015
The cancer-associated Sm-like (CaSm) oncogene is overexpressed in 87% of human pancreatic tumor samples and CaSm knockdown has demonstrated therapeutic efficacy in murine models of pancreatic cancer.
Lymphocyte phosphatase-associated phosphoprotein proteoforms analyzed using monoclonal antibodies.
Mazurov et al., Moscow, Russia. In Clin Transl Immunology, Oct 2015
A candidate for such a molecule is a small transmembrane adapter protein called lymphocyte phosphatase-associated phosphoprotein (LPAP).
Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans.
Cerón et al., Bordeaux, France. In Rna, Sep 2015
To date, the nuclear LSm2-8 and the cytoplasmic LSm1-7 heteroheptamers are the best characterized complexes in eukaryotes.
The Lsm1-7-Pat1 complex promotes viral RNA translation and replication by differential mechanisms.
Díez et al., Barcelona, Spain. In Rna, Aug 2015
The Lsm1-7-Pat1 complex binds to the 3' end of cellular mRNAs and promotes 3' end protection and 5'-3' decay.
The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs.
Fabian et al., Montréal, Canada. In Cell Rep, Jul 2015
Here, we show that 4E-T is a component of the mRNA decay machinery and interacts with factors including DDX6, LSM14, and the LSM1-7-PAT1 complex.
LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.
Xu et al., Xi'an, China. In Int J Mol Med, Jun 2015
In the present study LSm1 was identified as a host cellular protein involved in DENV RNA replication.
Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.
Khan et al., Miami, United States. In Front Immunol, 2014
MZ B-cells possessed the most distinct transcriptome including down-regulation of CD45 phosphatase-associated protein (CD45-AP/PTPRC-AP), as well as upregulation of IL-9R and innate molecules TLR3, TLR7, and bactericidal Perforin-2 (MPEG1).
Epitope mapping of lymphocyte phosphatase-associated phosphoprotein.
Mazurov et al., Moscow, Russia. In Biochemistry (mosc), 2014
Lymphocyte phosphatase-associated phosphoprotein (LPAP) is a transmembrane protein with unknown function.
Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye.
Heissmeyer et al., München, Germany. In Wiley Interdiscip Rev Rna, 2014
Such 3' oligouridylated transcripts are preferentially bound by the heteroheptameric LSM1-7 complex, which also interacts with the 3'→5' exonuclease ERI1 (also called 3'hExo).
The role of disordered protein regions in the assembly of decapping complexes and RNP granules.
Izaurralde et al., Tübingen, Germany. In Genes Dev, 2014
These factors include enhancer of decapping 3 (EDC3), EDC4, like Sm14A (LSm14A), Pat, the LSm1-7 complex, and the RNA helicase DDX6.
Lsm1 promotes genomic stability by controlling histone mRNA decay.
Moreno et al., Salamanca, Spain. In Embo J, 2011
The authors identify histone mRNAs as substrates of the Lsm1-7-Pat1 complex in yeast, and show that abnormally high amounts of histones accumulate in lsm1Delta mutant cells.
3' Uridylation and the regulation of RNA function in the cytoplasm.
Norbury, Oxford, United Kingdom. In Biochem Soc Trans, 2010
Accumulation of uridylated RNAs in an lsm1 mutant suggests an involvement of the Lsm1-7 complex in recognition of the 3' uridylation tag and recruitment of the decapping machinery.
A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression.
Kang et al., Taejŏn, South Korea. In Neoplasia, 2009
Data show that the minor allele of rs869736 in the PTPRCAP promoter is associated with increased susceptibility to diffuse-type gastric cancer by increasing PTPRCAP expression.
LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels.
Parker et al., Tucson, United States. In Nucleic Acids Res, 2009
LSM1 over-expression in the yeast Saccharomyces cerevisiae inhibits growth primarily due to U6 snRNA depletion, thereby altering pre-mRNA splicing.
Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.
Beggs et al., Edinburgh, United Kingdom. In Febs J, 2009
Results describe a range of mutant and hybrid Lsm1 and Lsm8 proteins, shedding light on the relative importance of their various domains in determining their localization and ability to support growth.
Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control.
Achsel et al., Roma, Italy. In J Cell Biol, 2009
Results describe a novel mRNP complex, containing LSm1 and CBP80, that is found in neuronal dendrites throughout the central nervous system and in some axonal processes of the spinal cord.
Gene therapy developments for pancreatic cancer.
Lemoine et al., London, United Kingdom. In Best Pract Res Clin Gastroenterol, 2006
Gene therapy approaches include inhibition of activated oncogenes (KRAS, LSM1) with antisense and RNA interference strategies, replacement of inactivated tumour suppressor genes (TP53, CDKN2A, CDKN1A), targeting of cell signalling pathways, gene-directed prodrug-activation therapies and the use of replication-competent oncolytic viruses.
The role of CD45 and CD45-associated molecules in T cell activation.
Sloan et al., Canberra, Australia. In Immunol Cell Biol, 1997
CD45-AP and LPAP) has become better understood in recent years, the role of others still remains obscure.
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