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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Limbic system-associated membrane protein

immunoglobulin (Ig) superfamily member; may act as a recognition molecule for the formation of neuronal connections [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, GAP-43, CAN, SET, Essential Tremor
Papers on LSAMP
Polygenic associations of neurodevelopmental genes in suicide attempt.
Wasserman et al., Stockholm, Sweden. In Mol Psychiatry, Jan 2016
Among the 590 SA polygenes implicated here, there were several developmentally important functions (cell adhesion/migration, small GTPase and receptor tyrosine kinase signaling), and 16 of the SA polygenes have previously been studied in SB (BDNF, CDH10, CDH12, CDH13, CDH9, CREB1, DLK1, DLK2, EFEMP1, FOXN3, IL2, LSAMP, NCAM1, nerve growth factor (NGF), NTRK2 and TBC1D1).
Cell type- and brain region-resolved mouse brain proteome.
Simons et al., Martinsried, Germany. In Nat Neurosci, Dec 2015
To demonstrate the utility of our resource, we focused on this class of proteins and identified Lsamp, an adhesion molecule of the IgLON family, as a negative regulator of myelination.
Overexpression of the LSAMP and TUSC7 genes in acute myeloid leukemia following microdeletion/duplication of chromosome 3.
Albano et al., Bari, Italy. In Cancer Genet, Oct 2015
Among the genes located within the deleted region, the involvement of the limbic system-associated membrane protein gene (LSAMP), together with a non-coding RNA tumor suppressor candidate 7 gene (TUSC7), has been suggested.
Gene expression patterns and environmental enrichment-induced effects in the hippocampi of mice suggest importance of Lsamp in plasticity.
Philips et al., Tartu, Estonia. In Front Neurosci, 2014
Limbic system associated membrane protein (Lsamp) gene is involved in behavioral adaptation in social and anxiogenic environments and has been associated with a broad spectrum of psychiatric diseases.
Lsamp is implicated in the regulation of emotional and social behavior by use of alternative promoters in the brain.
Vasar et al., Tartu, Estonia. In Brain Struct Funct, 2014
Limbic system-associated membrane protein (LSAMP) is a neural cell adhesion molecule involved in neurite formation and outgrowth.
Identification of pathways for bipolar disorder: a meta-analysis.
Psychiatric Genomics Consortium Bipolar Group et al., San Diego, United States. In Jama Psychiatry, 2014
Among the 226 genes, 9 differed in expression in the dorsolateral prefrontal cortex in patients with BP: CACNA1C, DTNA, FOXP1, GNG2, ITPR2, LSAMP, NPAS3, NCOA2, and NTRK3.
Associations between polymorphisms of LSAMP gene and schizophrenia.
Vasar et al., Tartu, Estonia. In Psychiatry Res, 2014
The purpose of this study was to explore relationships between single-nucleotide polymorphisms (SNPs) in the limbic system-associated membrane protein (LSAMP) gene and schizophrenia.
Intratumoral heterogeneity of genomic imbalance in a case of epithelioid glioblastoma with BRAF V600E mutation.
Nakazato et al., Maebashi, Japan. In Brain Pathol, 2014
Array comparative genomic hybridization separately performed for each histologically distinct component demonstrated eight shared copy number alterations (CNAs) and three CNAs observed only in epithelioid cells; one of the latter was a homozygous deletion of a tumor suppressor gene, LSAMP, at 3q13.31.
Microduplication 3q13.2q13.31 identified in a male with dysmorphic features and multiple congenital anomalies.
Tzetis et al., Chaniá, Greece. In Am J Med Genet A, 2014
duplicated region in our patient contains nine dosage sensitive genes, amongst them the genes ATG3, CCDC80, KIAA2018, NAA50, ZDHHC23, DRD3, ZBTB20, GAP43, LSAMP.
Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model.
Meza-Zepeda et al., Oslo, Norway. In Mol Cancer, 2013
We have identified LSAMP as the target gene for the deletion, and have studied the functional implications of LSAMP-reexpression.
Adult expression of a 3q13.31 microdeletion.
Bassett et al., Toronto, Canada. In Mol Cytogenet, 2013
The 2.06 Mb deletion overlapped two microRNAs and seven RefSeq genes, including GAP43, LSAMP, DRD3, and ZBTB20.
Genetic variants in nuclear factor-kappa B binding sites are associated with clinical outcomes in prostate cancer patients.
Bao et al., Kao-hsiung, Taiwan. In Eur J Cancer, 2013
LSAMP rs13088089, CCL17 rs223899, PSMD7 rs2387084 and MON1B rs284924 remained the significant predictors for PCSM whilst PSMD7 rs2387084 remained a significant predictor for ACM in multivariate models including clinical predictors.
Expanding the clinical phenotype at the 3q13.31 locus with a new case of microdeletion and first characterization of the reciprocal duplication.
Rooryck et al., Bordeaux, France. In Mol Genet Metab, 2013
This microduplication involves three strong candidate genes for the developmental delay ZBTB20, LSAMP and GAP43.
A rare 3q13.31 microdeletion including GAP43 and LSAMP genes.
Tassano et al., Genova, Italy. In Mol Cytogenet, 2012
deletion containing only two genes, GAP43 and LSAMP.
Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.
Fletcher et al., Boston, United States. In Int J Oncol, 2009
Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.
LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization.
Meza-Zepeda et al., Oslo, Norway. In Genes Chromosomes Cancer, 2009
results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas
Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression.
Cotter et al., Dublin, Ireland. In Mol Psychiatry, 2009
proteomic assessments of membrane microdomains in prefrontal cortex and validation in two brain series, strongly implicates LAMP, STXBP1 and BASP1 in schizophreina and supports the view of a neuritic and synaptic dysfunction in the neuropathology
Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.
Vance et al., Miami, United States. In Ann Hum Genet, 2008
Single nucleotide polymorphisms of LSAMP is associated with the pathogenesis of coronary artery disease.
Association of limbic system-associated membrane protein (LSAMP) to male completed suicide.
Väli et al., Tartu, Estonia. In Bmc Med Genet, 2007
LSAMP might play a role in pathoaetiology of suicidal behaviour but further studies are needed to understand its exact contribution
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.
Teh et al., Grand Rapids, United States. In Cancer Cell, 2003
LSAMP and NORE1 (RASSF1 homolog).
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