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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Leucine rich repeat neuronal 3

LRRN3, Neuronal leucine-rich repeat protein-3, hNLRR-3
acts to facilitate increased EGF induced phosphorylation of MAPK; may play a role in internalization of EGF via clathrin-coated vesicles [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, AGE, SET, HAD, IDS
Papers on LRRN3
Identification of gene expression signature for cigarette smoke exposure response-from man to mouse.
Peitsch et al., Neuchâtel, Switzerland. In Hum Exp Toxicol, Dec 2015
The signature consisted of LRRN3, SASH1, PALLD, RGL1, TNFRSF17, CDKN1C, IGJ, RRM2, ID3, SERPING1, and FUCA1.
Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation.
Chadeau-Hyam et al., Tromsø, Norway. In Hum Mol Genet, May 2015
Among genes whose expression was associated with our candidate CpG sites, LRRN3 appeared to be particularly interesting as it was one of the few genes whose methylation and expression were directly associated, and the only gene in which both methylation and gene expression were found associated with smoking.
Intracellular fragment of NLRR3 (NLRR3-ICD) stimulates ATRA-dependent neuroblastoma differentiation.
Nakagawara et al., Chiba, Japan. In Biochem Biophys Res Commun, 2014
We have previously identified neuronal leucine-rich repeat protein-3 (NLRR3) gene which is preferentially expressed in favorable human neuroblastomas as compared with unfavorable ones.
Transcriptomics of cortical gray matter thickness decline during normal aging.
Blangero et al., Baltimore, United States. In Neuroimage, 2013
RESULTS: Transcripts for eight genes (IGFBP3, LRRN3, CRIP2, SCD, IDS, TCF4, GATA3, and HN1) passed the transcriptome-wide significance threshold.
Accelerated aging in HIV/AIDS: novel biomarkers of senescent human CD8+ T cells.
Effros et al., Los Angeles, United States. In Plos One, 2012
Here, we compare adenosine deaminase (ADA), glucose uptake receptor 1 (GLUT1), and leucine-rich repeat neuronal 3 (LRRN3) to CD38 expression and telomerase activity, two strong predictors of HIV disease progression.
Differentially expressed genes in human peripheral blood as potential markers for statin response.
Lee et al., Seoul, South Korea. In J Mol Med (berl), 2012
The Charcol-Leyden crystal (CLC), CCR2, CX3CR1, LRRN3, FOS, LDLR, HLA-DRB1, ERMN, and TCN1 genes were significantly associated with cholesterol levels or statin response.
A whole blood gene expression-based signature for smoking status.
PREDICT Investigators et al., Palo Alto, United States. In Bmc Med Genomics, 2011
A five gene (CLDND1, LRRN3, MUC1, GOPC, LEF1) predictive model, derived from the qRT-PCR data using stepwise forward logistic regression, had a cross-validated mean AUC of 0.93 (sensitivity=0.78;
Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma.
Nakagawara et al., Chiba, Japan. In Clin Cancer Res, 2011
NLRR3 is a direct target of MYCN, which associates with Miz-1 and negatively regulates NLRR3 expression. NLRR3 may play a role in NBL differentiation and the survival of NBL patients by inversely correlating with MYCN amplification.
[Role of LRRN3 in the cerebellum postnatal development in rats].
Huang et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
LRRN3 plays an important role in postnatal cerebellum development.
Candidate genes associated with malignant pheochromocytomas by genome-wide expression profiling.
Kebebew et al., San Francisco, United States. In Ann Surg, 2009
Ten differentially expressed genes had high diagnostic accuracy, and 5 of these genes (CFC1, FAM62B, HOMER1, LRRN3, TBX3, ADAMTS) in combination had an area under the receiver operating characteristic (ROC) curve of 0.96 for distinguishing benign versus malignant tumors.
Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.
International Molecular Genetic Study of Autism Consortium (IMGSAC) et al., Oxford, United Kingdom. In Mol Autism, 2009
Here we present an association study analysing the roles of four promising candidate genes - LRRTM1 (2p), LRRTM3 (10q), LRRN1 (3p) and LRRN3 (7q) - in order to identify common genetic risk factors underlying ASDs.
Identification of novel human neuronal leucine-rich repeat (hNLRR) family genes and inverse association of expression of Nbla10449/hNLRR-1 and Nbla10677/hNLRR-3 with the prognosis of primary neuroblastomas.
Nakagawara et al., Chiba, Japan. In Int J Oncol, 2004
From them, we have identified 3 genes of human neuronal leucine-rich repeat protein (NLRR) family: Nbla10449/hNLRR-1, Nbla00061/hNLRR-2/GAC1 and Nbla10677/hNLRR-3.
Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes.
Haines et al., Nashville, United States. In Bmc Med Genet, 2004
Four candidate genes (NRCAM, LRRN3, KIAA0716, and LAMB1) in this region were chosen for examination based on their proximity to the marker most consistently cosegregating with autism in these families (D7S1817), their tissue expression patterns, and likely biological relevance to autism.
Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs.
Tsuda et al., Tokyo, Japan. In J Biol Chem, 2002
NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles
Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.
Tsuda et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2001
rNLRR-3 gene expression is regulated mainly through the Ras-MAPK signaling pathway in fibroblasts
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