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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Major vault protein

member of a large cytosolic ribonucleoprotein particle; may play a role in vault function [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, CD45, APP
Papers on M VP
[Prognostic significance of Pgp, MRP1, and MRP3 in ovarian cancer patients].
Špaček et al., In Ceska Gynekol, 31 Dec 2016
Patients with complete response after primary treatment had lower levels of LRP, Pgp, and MRP1 expression than other patients.
Key role of Dkk3 protein in inhibition of cancer cell proliferation: An in silico identification.
Khalili et al., Tehrān, Iran. In J Theor Biol, Feb 2016
Herein, we aimed at launching an in silico study to determine Dkk3 structure and its interactions with Kremen and LRP as Wnt signaling receptors as well as EGF receptor.
PIK3CA and PIK3CB silencing by RNAi reverse MDR and inhibit tumorigenic properties in human colorectal carcinoma.
Tian et al., Binzhou, China. In Tumour Biol, Feb 2016
In the present study, we showed that PIK3CA and PIK3CB are upregulated in CRCs and positively correlated with MDR-1, LRP, and GST-π.
Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood-brain barrier model.
Langel et al., Bangkok, Thailand. In Int J Pharm, Feb 2016
PepFect 32 (PF32), a peptide-based vector modified with targeting ligand (Angiopep-2) binding to low-density lipoprotein receptor-related protein-1 (LRP-1), was previously found to be a promising vector for plasmid delivery across an in vitro model of the BBB.
Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one schiff bases.
Raghuram R et al., Warangal, India. In Bioorg Med Chem Lett, Jan 2016
The compounds 6b, 6c, 6d, 6k, 7b, 7c, 7d and 7k exhibited promising antibacterial activity MIC in the range of 15-73μM against all bacterial strains used and compounds 6d and 7b showed antimycobacterial activity (IC50 <340μM in LRP assay) and (MIC <9μM in broth microdilution method).
Protein structures in Alzheimer's disease: The basis for rationale therapeutic design.
Villegas et al., Barcelona, Spain. In Arch Biochem Biophys, Jan 2016
Thus, structural information available for APP, α- β- and γ-secretases, CTFβ and derived Aβ peptides, AICDs, apoE and apoJ, LRP-1 and RAGE, and neprilysin and insulin-degrading enzyme is provided.
An update on laboratory diagnosis in myasthenia gravis.
Frykman et al., Vancouver, Canada. In Clin Chim Acta, Oct 2015
They also describe the methods to measure each of the specific antibodies that have recently permitted to split the diagnosis: Abs to omega-conotoxin receptor in Lambert Eaton Myasthenic Syndrome (LEMS), abs to the acetylcholine receptor (AchR) in MG, Abs to muscle specific tyrosine kinase (MuSK) in Ab negative MG, and Abs to low molecular weight receptor related low-density lipo protein-4 (LRP-4).
LRP receptor family member associated bone disease.
Johnson et al., Kansas City, United States. In Rev Endocr Metab Disord, Jun 2015
In this review we discuss some of the most recent reports (in the past 2 years) highlighting the involvement of the members of the LRP family (LRP5, LRP6, LRP4, and more recently LRP8) in the maintenance of bone and their implications in bone diseases.
[The role of Wnt/β-catenin pathway and LRP5 protein in metabolism of bone tissue and osteoporosis etiology].
Czerny et al., In Ginekol Pol, Apr 2015
In recent years, much attention has been paid to the role of signaling Wnt/β-catenin pathway and LRP protein in the pathomechanism of osteoporosis, indicating a possible contribution of polymorphic variants of the candidate LRP5 gene to disease development.
Biochemistry and genetics of ACC deaminase: a weapon to "stress ethylene" produced in plants.
Jha et al., Pilani, India. In Front Microbiol, 2014
Regulatory elements of gene AcdS are comprised of the regulatory gene encoding LRP protein and other regulatory elements which are activated differentially under aerobic and anaerobic conditions.
Auxin regulates aquaporin function to facilitate lateral root emergence.
Bennett et al., Nottingham, United Kingdom. In Nat Cell Biol, 2012
The highly expressed aquaporin PIP2;1 is progressively excluded from the site of the auxin response maximum in lateral root primordia (LRP) whilst being maintained at their base and underlying vascular tissues.
Vacuolar H+ -ATPase c protects glial cell death induced by sodium nitroprusside under glutathione-depleted condition.
Jeong et al., Seoul, South Korea. In J Cell Biochem, 2011
ATP6L has a protective role against SNP-induced autophagic cell death via inhibition of JNK and p38 in GSH-depleted glial cells.
Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy.
Cossart et al., Paris, France. In Plos Pathog, 2011
MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles.
Early-onset progressive myoclonic epilepsy with dystonia mapping to 16pter-p13.3.
Tolun et al., İstanbul, Turkey. In J Neurogenet, 2010
Novel recessive myoclonic epilepsy candidate gene myoclonic epilepsy , but no mutation was found.
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.
O'Connor et al., Cork, Ireland. In J Biol Chem, 2010
HRG-1 regulates V-ATPase activity, which is essential for endosomal acidification, heme binding, and receptor trafficking in mammalian cells.
The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.
Verdaguer et al., Barcelona, Spain. In Embo J, 2009
The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, provide an explanation for a reversible dissociation induced by low pH.
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.
Zlokovic et al., Rochester, United States. In Nat Cell Biol, 2009
Amyloid beta-peptide (Abeta) deposition in cerebral vessels contributes to cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD).
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Strickland et al., Baltimore, United States. In Physiol Rev, 2008
The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a large endocytic receptor that is widely expressed in several tissues.
Clearance of amyloid-beta by circulating lipoprotein receptors.
Zlokovic et al., Rochester, United States. In Nat Med, 2007
Low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid beta-peptide (Abeta) from brain.
Artificial reporter gene providing MRI contrast based on proton exchange.
van Zijl et al., Baltimore, United States. In Nat Biotechnol, 2007
We designed a nonmetallic, biodegradable, lysine rich-protein (LRP) reporter, the prototype of a potential family of genetically engineered reporters expressing artificial proteins with frequency-selective contrast.
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