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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nuclear receptor subfamily 5, group A, member 2

LRH-1, FTZ-F1, FTF, liver receptor homolog-1, NR5A2
an orphan nuclear receptor that may bind DNA and activate gene transcription [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, SF-1, V1a, CAN, SHP1
Papers on LRH-1
Polymorphisms in NR5A2, gene encoding Liver Receptor Homolog-1 are associated with Preterm Birth.
Murray et al., Buenos Aires, Argentina. In Pediatr Res, Feb 2016
NR5A2 gene encodes for the Liver receptor homolog 1(LRH1) protein, which plays a critical role in regulation of cholesterol metabolism, steroidogenesis and progesterone synthesis.
MicroRNA-381 suppresses cell growth and invasion by targeting the liver receptor homolog-1 in hepatocellular carcinoma.
Chi et al., Changchun, China. In Oncol Rep, Jan 2016
Bioinformatics analysis and dual-luciferase reporter assay results showed that miR-381 directly targeted the 3'-untranslated region of liver receptor homolog-1 (LRH-1), and quantitative polymerase chain reaction and western blot analysis results showed that miR-381 negatively modulated LRH-1 expression.
A gene-expression screen identifies a non-toxic sumoylation inhibitor that Mimics SUMO-less human LRH-1 in liver.
Ingraham et al., San Francisco, United States. In Elife, Jan 2016
Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that focused on the well-sumoylated substrate, human Liver Receptor Homolog-1 (hLRH-1, NR5A2).
Intestinal steroidogenesis.
Bertin et al., Rennes, France. In Steroids, Nov 2015
Glucocorticoid synthesis regulation in the intestinal epithelial cells is unique in that it does not involve the classical positive regulator steroidogenic factor-1 (SF-1) but a closely related homolog, namely the liver receptor homolog-1 (LRH-1).
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Klein et al., Baltimore, United States. In Nat Genet, Aug 2015
(PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3).
Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1.
Taniguchi et al., Asahikawa, Japan. In Zoolog Sci, Aug 2015
Steroidogenic factor-1 (SF-1) and liver receptor homolog-1 (LRH-1) belong to the nuclear receptor superfamily and are categorized as orphan receptors.
Apolipoprotein M.
Yi et al., Hengyang, China. In Clin Chim Acta, Jul 2015
Multiple factors may influence its expression at both the post-transcriptional and the transcriptional levels both in vivo and ex vivo as follows: hepatocyte nuclear factor-1α, 4α (HNF-1α, 4α), liver receptor homolog-1 (LRH-1), forkhead box A2 (Foxa2) and platelet activating factor (PAF) upregulate its expression; liver X receptor (LXR), retinoid X receptor (RXR), farnesoid X receptor (FXR), small heterodimer partner (SHP) and the majority of cytokines downregulate its expression.
Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese.
Lin et al., Japan. In Sci Rep, 2014
We genotyped 2 SNPs (rs3790844 T/C and rs3790843 G/A) in the NR5A2 gene that were identified in a genome-wide association study (GWAS) of pancreatic cancer in populations of mainly European ancestry, and we examined their associations with pancreatic cancer risk in a case-control study of 360 patients and 400 control subjects in Japan.
Nuclear receptor variants in liver disease.
Lammert et al., Homburg, Germany. In Dig Dis, 2014
Other examples include studies of NR1I2 and NR1I3 polymorphisms in patients with drug-induced liver injury and NR5A2 variation in cholangiocarcinoma.
Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer.
Dong et al., United States. In Cancer Biol Ther, 2014
Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in various biological processes.
Dysfunction of Liver Receptor Homolog-1 in Decidua: Possible Relevance to the Pathogenesis of Preeclampsia.
Zhang et al., Shanghai, China. In Plos One, 2014
NR5A1 and NR5A2 are orphan members of the Ftz-F1 subfamily of nuclear receptors and are involved in mammal follicular development, female reproduction, steroidogenesis, and decidualization.
SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.
Schoonjans et al., Lausanne, Switzerland. In Cell Metab, 2014
The nuclear receptor liver receptor homolog 1 (LRH-1) drives expression of genes regulating RCT, and its activity can be modified by different posttranslational modifications.
SUMOylation places LRH-1 in PROXimity to lipid metabolism.
Tontonoz et al., Los Angeles, United States. In Cell Metab, 2014
In this issue of Cell Metabolism, Stein et al. (2014) establish LRH-1 as an important regulator of reverse cholesterol transport and identify SUMOylation as a primary mode of LRH-1 regulation.
Liver receptor homolog-1 is essential for pregnancy.
Murphy et al., Saint-Hyacinthe, Canada. In Nat Med, 2013
One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis.
LRH-1-dependent glucose sensing determines intermediary metabolism in liver.
Schoonjans et al., Lausanne, Switzerland. In J Clin Invest, 2012
in conditional deletion of Lrh1 in liver, analysis of hepatic glucose fluxes revealed reduced glucokinase and glycogen synthase fluxes as compared with those of wild-type littermates
NR5A nuclear receptor Hr39 controls three-cell secretory unit formation in Drosophila female reproductive glands.
Spradling et al., Baltimore, United States. In Curr Biol, 2012
The NR5A-class nuclear hormone receptor Hr39 is essential for precursor cell division and secretory unit formation in Drosophila spermathecae.
Nuclear receptors reverse McGarry's vicious cycle to insulin resistance.
Moore, Houston, United States. In Cell Metab, 2012
Here I suggest that reversing this cycle via suppression of the lipogenic transcription factor SREBP-1c is a common thread that connects the antidiabetic effects of a surprising number of nuclear hormone receptors, including CAR, LRH-1, TRβ, ERα, and FXR/SHP.
Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Ortlund et al., Atlanta, United States. In Nat Struct Mol Biol, 2012
The lipid-free receptor undergoes previously unrecognized structural fluctuations, allowing it to interact with widely expressed co-repressors.
Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.
Osborne et al., Irvine, United States. In Bmc Genomics, 2011
LRH-1 recruits FXR to lipid metabolic genes.
The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation.
Clyne et al., Australia. In Plos One, 2011
in ER-positive breast cancer cells, LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1
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