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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Leucine-rich alpha-2-glycoprotein 1

LRG, leucine-rich alpha-2-glycoprotein, leucine-rich alpha-2-glycoprotein-1
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CD45, CAN, fibrillin-1, ACID, IFN-gamma
Papers using LRG antibodies
Normal pressure hydrocephalus. Predictive value of the cerebrospinal fluid tap-test
Hashimoto Yasuhiro et al., In Acta Neurochirurgica, 1985
... (IBL©) in order to prepare a sandwich ELISA kit (Human LRG Assay Kit-IBL).
Papers on LRG
Discovery of potential colorectal cancer serum biomarkers through quantitative proteomics on the colonic tissue interstitial fluids from the AOM-DSS mouse model.
Liu et al., Beijing, China. In J Proteomics, Mar 2016
The abundances of leucine-rich alpha-2-glycoprotein 1 (LRG1), tubulin beta-5 chain (TUBB5) and immunoglobulin J chain (IGJ) were significantly higher in CRC mice than in control mice.
In vitro dioxin-like potencies of HO- and MeO-PBDEs and inter-species sensitivity variation in birds.
Yu et al., Nanjing, China. In Ecotoxicol Environ Saf, Feb 2016
In the present study, an avian AHR1 luciferase reporter gene (LRG) assay with luciferase probes from chicken, pheasant and quail was used to test activations of avian aryl hydrocarbon receptor (AHR)-mediated pathways by 19 HO- or MeO-PBDEs in different avian species.
Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.
Naka et al., Suita, Japan. In Cardiovasc Res, Jan 2016
AIMS: Leucine-richα2-glycoprotein (LRG) is considered as a biomarker of the clinical activities of chronic inflammatory diseases, includingheart failure.
Mice lack of LRG-47 display the attenuated outcome of infection with Schistosoma japonicum.
Ji et al., Nanjing, China. In Parasitol Res, Jan 2016
UNASSIGNED: Interferon-inducible GTPase LRG-47 (also named immune-related GTPase M, Irgm1) is a member of the p47 GTPase family that has been shown to regulate host resistance to intracellular pathogens.
Plasma Protein Biomarker Candidates for Myelodysplastic Syndrome Subgroups.
Dyr et al., Praha, Czech Republic. In Biomed Res Int, 2014
Reanalysis of a total of 47 MDS patients revealed biomarker candidates, with alpha-2-HS-glycoprotein and leucine-rich alpha-2-glycoprotein as the most promising candidates.
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
Greenwood et al., London, United Kingdom. In Nature, 2013
Here we explore the transcriptome of retinal microvessels isolated from mouse models of retinal disease that exhibit vascular pathology, and uncover an upregulated gene, leucine-rich alpha-2-glycoprotein 1 (Lrg1), of previously unknown function.
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women.
Hanash et al., Seattle, United States. In Cancer Prev Res (phila), 2012
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 precede a diagnosis of colorectal cancer in women
Brain localization of leucine-rich α2-glycoprotein and its role.
Arai et al., Tokyo, Japan. In Acta Neurochir Suppl (wien), 2011
This study demonistrated that LRG expression in resident astrocytes increased with age.
Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC.
Qiu et al., Chongqing, China. In Electrophoresis, 2011
Screened for NSCLC-related proteins in urinary exosomes by comparing urinary exosomes proteome of normal controls and NSCLC patients. The LRG1 was found to be expressed at higher levels in urinary exosomes and lung tissue of NSCLC patients.
Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure.
Baugh et al., Dublin, Ireland. In Circ Heart Fail, 2011
LRG1 was identified as a serum biomarker that accurately identifies patients with heart failure.
Autologous extracellular cytochrome c is an endogenous ligand for leucine-rich alpha2-glycoprotein and beta-type phospholipase A2 inhibitor.
Inoue et al., Takatsuki, Japan. In J Biol Chem, 2010
autologous Cyt c is an endogeneous ligand for LRG and PLIbeta and these serum proteins neutralize the autologous Cyt c released from the dead cells
The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
Goodell et al., Bethesda, United States. In Cell Stem Cell, 2008
We report that the interferon-inducible GTPase Lrg-47 (Irgm1), previously shown to play a critical role in host defense, inhibits baseline HSC proliferation and is required for a normal HSC response to chemical and infectious stimuli.
Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads.
Sklar et al., Albuquerque, United States. In Adv Protein Chem, 2006
The binding of full and partial agonist ligands (L) to G protein-coupled receptors (GPCRs) initiates the formation of ternary complexes with G proteins [ligand-receptor-G protein (LRG) complexes].
Human IRGM induces autophagy to eliminate intracellular mycobacteria.
Deretic et al., Albuquerque, United States. In Science, 2006
We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis.
Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism.
Vergne et al., Albuquerque, United States. In Cell Microbiol, 2006
Induction of autophagy by physiological, pharmacological or immunological signals, including the major antituberculosis Th1 cytokine IFN-gamma and its downstream effector p47 GTPase LRG-47, can overcome mycobacterial phagosome maturation block and inhibit intracellular M. tuberculosis survival.
Immune control of tuberculosis by IFN-gamma-inducible LRG-47.
McKinney et al., New York City, United States. In Science, 2003
Here, we identify one member of a newly emerging 47-kilodalton (p47) guanosine triphosphatase family, LRG-47, that acts independently of NOS2 to protect against disease.
[Biochemistry of platelet membrane glycoproteins].
Ando, Funaishikawa, Japan. In Nihon Rinsho, 2003
Many of these glycoproteins are now cloned and sequenced and have been found to be members of major gene families, such as integrin, leucine rich glycoprotein (LRG), selectin, etc.
Molecular defects in the Bernard-Soulier syndrome: assessment of receptor genes, transcripts and proteins.
Roth, Seattle, United States. In C R Acad Sci Iii, 1996
This receptor, termed glycoprotein (GP) Ib-IX-V, consists of 4 distinct polypeptides (GPs: Ib alpha-143 kDa, Ib beta-22 kDa, IX-20 kDa, V-83 kDa) that share features such as physical associations and leucine-rich glycoprotein (LRG) repeats.
[Second messenger-mediated transcriptional regulation of neural genes and possible drug action sites].
Li et al., Ōsaka, Japan. In Nihon Yakurigaku Zasshi, 1995
As to the neuropeptide Y (NPY) gene, a typical neuronal LRG, the approach was introduced to elucidate the transcriptional regulations of the NPY gene induced by membrane depolarization and NGF-induced neuronal differentiation.
Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.
Seeburg et al., San Francisco, United States. In Science, 1989
As would be predicted from the cDNA sequence, the LH-CG-R consists of a 26-residue signal peptide, a 341-residue extracellular domain displaying an internal repeat structure characteristic of members of the leucine-rich glycoprotein (LRG) family, and a 333-residue region containing seven transmembrane segments.
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