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Phosphatidic acid phosphatase type 2B

LPP3, PAP2b, Ppap2b, lipid phosphate phosphohydrolase-3, VCIP
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: ACID, LPP, CAN, LPP2, PAP
Papers on LPP3
A map of the distribution of sphingosine 1-phosphate in the spleen.
Schwab et al., New York City, United States. In Nat Immunol, Dec 2015
The lipid phosphate phosphatase LPP3 maintained low S1P concentrations in the spleen and enabled efficient shuttling of marginal zone B cells.
LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells.
Aoki et al., Sendai, Japan. In J Cell Sci, Dec 2015
Here, we focused on an LPA-degrading enzyme, lipid phosphate phosphatase 3 (LPP3, also known as PPAP2B), and showed that LPP3 was localized in specific cell-cell contact sites of endothelial cells and suppresses LPA signalling through the LPA6 receptor (also known as LPAR6).
Lipid phosphate phosphatases and their roles in mammalian physiology and pathology.
Brindley et al., Edmonton, Canada. In J Lipid Res, Nov 2015
Mammalian LPPs consist of three isoforms: LPP1, LPP2, and LPP3.
Lysophospholipids in coronary artery and chronic ischemic heart disease.
Smyth et al., Lexington, United States. In Curr Opin Lipidol, Oct 2015
This is supported by observations of human polymorphisms in the lysophospholipid-metabolizing enzyme PPAP2B, which are associated with risk of coronary artery disease and myocardial infarction.
Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
Fang et al., Paris, France. In Circ Res, Aug 2015
RATIONALE: PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies.
Sobiczewski et al., Gdańsk, Poland. In J Hypertens, Jun 2015
CONCLUSIONS: The PROGNOSIS study revealed relationship between SNPs: CXCL12, LPA, MRAS and PPAP2B and risk of MACE, MIA3 and risk of ACS and CXCL12, PHACTR1 and risk of revascularizations in patients with CHD.
An epigenetically distinct breast cancer cell subpopulation promotes collective invasion.
Pearson et al., In J Clin Invest, May 2015
Functional analysis determined that DOCK10, ITGA11, DAB2, PDFGRA, VASN, PPAP2B, and LPAR1 are highly expressed in trailblazer cells and required to initiate collective invasion, with DOCK10 essential for metastasis.
Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
O'Callaghan et al., Oxford, United Kingdom. In Plos Genet, Apr 2015
In addition, expression of the PPAP2B protein product LPP3 was present in foam cells in human atherosclerotic plaques and oxLDL exposure up-regulated LPP3 in macrophages resulting in increased degradation of pro-inflammatory mediators.
Comparative analysis of internal ribosomal entry sites as molecular tools for bicistronic expression.
Skavdis et al., Alexandroúpolis, Greece. In J Biotechnol, 2014
Although the most widely used IRES comes from the encephalomyocarditis virus (EMCV), several other viral and cellular IRES elements have been identified and successfully used, including those of the human VCIP gene and the mouse Gtx gene.
Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability.
Smyth et al., Mexico. In Arterioscler Thromb Vasc Biol, 2014
OBJECTIVE: Lipid phosphate phosphatase 3 (LPP3), encoded by the PPAP2B gene, is an integral membrane enzyme that dephosphorylates, and thereby terminates, the G-protein-coupled receptor-mediated signaling actions of lysophosphatidic acid (LPA) and sphingosine-1-phosphate. LPP3 is essential for normal vascular development in mice, and a common PPAP2B polymorphism is associated with increased risk of coronary artery disease in humans.
Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis.
González-Gay et al., Santander, Spain. In Mediators Inflamm, 2013
Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals.
Association between TGM5, PPAP2B and PSMA4 polymorphisms and NSCLC in never-smoking Chinese population.
Xiangming Kong et al., Hangzhou, China. In J Cancer Res Ther, 2013
AIM: To explore the potential association between SNPs in transglutaminase 5 (TGM5), phosphatidic acid phosphatase type 2B (PPAP2B) and proteasome subunit, alpha type 4 (PSMA4) and non-small cell lung cancer (NSCLC) susceptibility in Chinese patients who were non-smokers.
Lipid phosphate phosphatase (LPP3) and vascular development.
Smyth et al., Lexington, United States. In Biochim Biophys Acta, 2013
A specific role for LPP3 in vascular development has emerged from studies of mice lacking Ppap2b.
Lack of lipid phosphate phosphatase-3 in embryonic stem cells compromises neuronal differentiation and neurite outgrowth.
Escalante-Alcalde et al., Mexico. In Dev Dyn, 2012
Our data show that LPP3 plays a fundamental role during spinal neuron differentiation from embryonic stem cells and that it also participates in regulating neurite and axon outgrowth.
Lipid phosphate phosphatase 3 enables efficient thymic egress.
Schwab et al., New York City, United States. In J Exp Med, 2011
generation and destruction are tightly regulated and LPP3 is essential to establish the balance
Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.
Escalante-Alcalde et al., Mexico. In Glia, 2011
Altogether our data indicate that LPP3 participates in several aspects of neuron-glia communication required for proper cerebellum development.
Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and CYCLIN-D1 signaling.
Wary et al., Chicago, United States. In Mol Cancer, 2010
expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased beta-catenin stability and CYCLIN-D1 synthesis
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.
Wary et al., San Francisco, United States. In Mol Cell Biol, 2010
Results identify a key role for LPP3 in orchestrating PTEN-mediated beta-catenin/LEF-1 signaling in EC migration, cell-cell adhesion, and formation of branching point structures.
Lipid phosphate phosphatases and signaling.
Pilquil et al., Edmonton, Canada. In J Lipid Res, 2009
The proposed integrin binding domain on the external surface of LPP3 modifies cell/cell interactions.
Lipid phosphate phosphatases and lipid phosphate signalling.
Pyne et al., Glasgow, United Kingdom. In Biochem Soc Trans, 2005
However, our recent work suggests that an intracellular action of LPP2 and LPP3 may account for the reduced agonist-stimulated p42/p44 mitogen-activated protein kinase activation of HEK-293 (human embryonic kidney 293) cells.
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