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Phosphatidic acid phosphatase type 2C

LPP2, Ppap2c, AtLPP2, PAP-2c, hPAP2c
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, LPP, LPP3, PAP, CAN
Papers on LPP2
Lipid phosphate phosphatases and their roles in mammalian physiology and pathology.
Brindley et al., Edmonton, Canada. In J Lipid Res, Nov 2015
Mammalian LPPs consist of three isoforms: LPP1, LPP2, and LPP3.
Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.
Lumey et al., Leiden, Netherlands. In Int J Epidemiol, Aug 2015
RESULTS: Famine exposure during gestation weeks 1-10, but not weeks 11-20, 21-30 or 31-delivery, was associated with an increase in DNA methylation of CpG dinucleotides cg20823026 (FAM150B), cg10354880 (SLC38A2) and cg27370573 (PPAP2C) and a decrease of cg11496778 (OSBPL5/MRGPRG) (P < 5.9 × 10(-7), PFDR < 0.031).
Semiparametric Bayesian local functional models for diffusion tensor tract statistics.
Zhu et al., Chapel Hill, United States. In Neuroimage, 2012
A nonparametric Bayesian LPP2 prior facilitates global and local borrowings of information among subjects, while an infinite factor model flexibly represents low-dimensional structure.
Arabidopsis thaliana lipid phosphate phosphatase 2 is involved in abscisic acid signalling in leaves.
Jeannette et al., Paris, France. In Plant Physiol Biochem, 2011
Taken together our observations show that AtLPP2 is a part of ABA signalling and participate to the regulation of stomatal movements.
Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.
Boshoff et al., London, United Kingdom. In Mol Cancer Ther, 2009
Only three enzymes (RNASEH2A, ADARB1, and PPAP2C) are potentially novel targets that are up-regulated in transformed MSC and expressed in numerous carcinomas and sarcomas.
A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
Kihara et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2008
In the present study, we investigated activities toward FTY720-P of LPP family members (LPP1, LPP1a, LPP2, and LPP3), which exhibit broad substrate specificity.
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.
Pyne et al., Glasgow, United Kingdom. In Biochem J, 2008
endogenous LPP2 and LPP3 form homo- and hetero-oligomers, which differ in their subcellular localization and which may confer differing spatial regulation of phosphatidic acid and sphingosine 1-phosphate signalling
Molecular and morphological characterization of heterorhabditid entomopathogenic nematodes from the tropical rainforest in Brazil.
Winter et al., Rio de Janeiro, Brazil. In Mem Inst Oswaldo Cruz, 2008
Based on morphometrics and internal transcribed spacer (ITS) sequence data, the strains LPP1, LPP2 and LPP4 were identified as Heterorhabditis indica, whereas LPP7 was considered Heterorhabditis baujardi.
Seed after-ripening is a discrete developmental pathway associated with specific gene networks in Arabidopsis.
Holdsworth et al., Harpenden, United Kingdom. In Plant J, 2008
Each set included a gene encoding repression or activation of ABA function (LPP2 and ABA1, respectively), thereby suggesting a mechanism through which dry AR may modulate subsequent germination potential in WT seeds.
Selection of entomopathogenic fungi for use in combination with sub-lethal doses of imidacloprid: perspectives for the control of the leaf-cutting ant Atta sexdens rubropilosa Forel (Hymenoptera: Formicidae).
Samuels et al., Campos, Brazil. In Mycopathologia, 2007
Vuillemin (LPP1, LPP2, CG05 and CG24) and one isolate of Metarhizium anisopliae (Metsch.)
Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.
Brindley et al., Edmonton, Canada. In J Biol Chem, 2006
identified a novel and specific role for LPP2 activity and bioactive lipids in regulating cell cycle progression
Lipid phosphate phosphatases and lipid phosphate signalling.
Pyne et al., Glasgow, United Kingdom. In Biochem Soc Trans, 2005
However, our recent work suggests that an intracellular action of LPP2 and LPP3 may account for the reduced agonist-stimulated p42/p44 mitogen-activated protein kinase activation of HEK-293 (human embryonic kidney 293) cells.
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.
Pyne et al., Glasgow, United Kingdom. In Biochem J, 2005
Therefore LPP2 and LPP3 appear to regulate the apoptotic status of serum-deprived HEK-293 cells.
An important role of phosphatidic acid in ABA signaling during germination in Arabidopsis thaliana.
Shinozaki et al., Tsukuba, Japan. In Plant J, 2005
Two AtLPP2 T-DNA insertional mutants (lpp2-1 and lpp2-2) showed hypersensitivity to ABA and significant PA accumulation during germination. [AtLPP2]
Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
Darroch et al., Glasgow, United Kingdom. In Semin Cell Dev Biol, 2004
The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2).
Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile.
Gridley et al., Bar Harbor, United States. In Genesis, 2000
Functional study of the mouse homolog
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