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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Lipin 2

LPIN2, lipin-2
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, lipin-3, CAN, PAP, Insulin
Papers on LPIN2
The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.
Schürmann et al., Potsdam, Germany. In Diabetologia, Oct 2015
Specifically, expression of Nampt, Lpin2, Map2k6, Gys2, Bnip3, Fitm2, Slc2a2, Ppargc1α and Insr was significantly decreased in the liver of B6-Tg(Zfp69) mice compared with wild-type animals.
Next-generation sequencing and its initial applications for molecular diagnosis of systemic auto-inflammatory diseases.
Ceccherini et al., Genova, Italy. In Ann Rheum Dis, Oct 2015
METHODS: Fifty patients with SAID, already genotyped for the respective causative gene(s), were massively sequenced for the coding portions of MEFV, MVK, TNFRSF1A, NLRP3, NLRP12, NOD2, PSTPIP1, IL1RN, LPIN2 and PSMB8.
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.
Deroanne et al., Liège, Belgium. In Oncotarget, Jun 2015
We also observed a compensatory regulation between lipin-1 and lipin-2 and demonstrated that their co-silencing aggravates the phenotype induced by lipin-1 silencing alone.
Variation in the chicken LPIN2 gene and association with performance traits.
Chen et al., Zhengzhou, China. In Br Poult Sci, Apr 2015
The objective of the study was to investigate the distribution of LPIN2 variants and haplotypes among breeds and perform an association analysis of the variants and haplotypes with the broiler traits in chickens.
Inborn errors of cytoplasmic triglyceride metabolism.
Mitchell et al., Montréal, Canada. In J Inherit Metab Dis, 2015
We discuss known inborn errors of CTGM, including deficiencies of: AGPAT2 (a form of generalized lipodystrophy), LPIN1 (childhood rhabdomyolysis), LPIN2 (an inflammatory condition, Majeed syndrome, described elsewhere in this issue), DGAT1 (protein loosing enteropathy), perilipin 1 (partial lipodystrophy), CGI-58 (gene ABHD5, neutral lipid storage disease (NLSD) with ichthyosis and "Jordan's anomaly" of vacuolated polymorphonuclear leukocytes), adipose triglyceride lipase (ATGL, gene PNPLA2, NLSD with myopathy, cardiomyopathy and Jordan's anomaly), hormone-sensitive lipase (HSL, gene LIPE, hypertriglyceridemia, and insulin resistance).
The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells.
Perera et al., Orlando, United States. In Oncotarget, 2014
To investigate its function further, we affinity purified SPRY4-IT1 from melanoma cells and used mass spectrometry to identify the protein lipin 2, an enzyme that converts phosphatidate to diacylglycerol (DAG), as a major binding partner.
Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-α activation in cultured human female hepatocytes.
Schroeder et al., East Lansing, United States. In Am J Physiol Gastrointest Liver Physiol, 2014
Cultured primary hepatocytes from female human subjects expressing the FABP1 T94A variant exhibited increased neutral lipid (TG, cholesteryl ester) accumulation associated with (1) upregulation of total FABP1, a key protein stimulating mitochondrial glycerol-3-phosphate acyltransferase (GPAM), the rate-limiting enzyme in lipogenesis; (2) increased mRNA expression of key enzymes in lipogenesis (GPAM, LPIN2) in heterozygotes; (3) decreased mRNA expression of microsomal triglyceride transfer protein; (4) increased secretion of ApoB100 but not TG; (5) decreased long-chain fatty acid (LCFA) β-oxidation.
Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.
Harris et al., Charlottesville, United States. In J Biol Chem, 2014
Lipin 2 is a phosphatidic acid phosphatase (PAP) responsible for the penultimate step of triglyceride synthesis and dephosphorylation of phosphatidic acid (PA) to generate diacylglycerol.
Gene structure and spatio-temporal expression of chicken LPIN2.
Mo et al., Zhengzhou, China. In Mol Biol Rep, 2014
LPIN2 is one of the members of the Lipin family, which acts as a phosphatidate phosphatase enzyme.
Lipin-1 and lipin-3 together determine adiposity in vivo.
Reue et al., Los Angeles, United States. In Mol Metab, 2014
Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious.
Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight.
Boeing et al., Potsdam, Germany. In Genes Nutr, 2014
We analysed single nucleotide polymorphisms (SNPs) tagging the genetic variability of six candidate genes (ATF6, FABP1, LPIN2, LPIN3, MLXIPL and MTTP) involved in the regulation of hepatic lipid metabolism, an important regulatory site of energy balance for associations with body mass index (BMI) and changes in weight and waist circumference.
Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers.
Ferguson et al., Iowa City, United States. In Curr Opin Rheumatol, 2013
Mutations in Pstpip2, LPIN2 and IL1RN have been identified in monogenic autoinflammatory bone disorders that have allowed more detailed dissection of the immunologic defects that can produce sterile osteomyelitis.
Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.
Reue et al., Los Angeles, United States. In Prog Lipid Res, 2013
Lipin function has been evolutionarily conserved from a single ortholog in yeast to the mammalian family of three lipin proteins-lipin-1, lipin-2, and lipin-3.
Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
Balboa et al., Barcelona, Spain. In J Biol Chem, 2012
role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages
Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance.
Koo et al., Seoul, South Korea. In Diabetes, 2011
The results demonstrate that ER stress-induced LIPIN2 would contribute to the perturbation of hepatic insulin signaling via a DAG-protein kinase C epsilon-dependent manner in DIO mice.
Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.
Itabe et al., Tokyo, Japan. In Plos One, 2010
Data show that in the high-Chol diet apoE-KO mice, the mRNA and protein expression of lipin-1 and lipin-2 was markedly decreased.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Yao et al., Ottawa, Canada. In Biochim Biophys Acta, 2010
Growing evidence links the three mammalian lipin proteins, i.e., lipin-1, lipin-2 and lipin-3, to metabolic and cardiovascular diseases such as noninsulin-dependent diabetes mellitus and atherosclerosis.
Lipin proteins form homo- and hetero-oligomers.
Harris et al., Beijing, China. In Biochem J, 2010
Data revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Reue et al., Los Angeles, United States. In J Biol Chem, 2009
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Majeed Syndrome
Ferguson et al., Seattle, United States. In Unknown Journal, 2008
DIAGNOSIS/TESTING: The diagnosis is based on clinical findings and molecular genetic testing of LPIN2, the only gene in which pathogenic variants are known to cause Majeed syndrome.
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